Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers

Abstract We report a simple surface functionalization of glutathione-capped gold nanoclusters by hydrophobic ion pairing with alkylamine followed by a complete phase transfer to various organic solvents with maintained colloidal stability and photoluminescence properties. The described surface hydro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alaaldin M. Alkilany, Shrouq Alsotari, Mahmoud Y. Alkawareek, Samer R. Abulateefeh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78f993e4b9704608b89959b0a957de45
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:78f993e4b9704608b89959b0a957de45
record_format	dspace
spelling	oai:doaj.org-article:78f993e4b9704608b89959b0a957de452021-12-02T15:08:46ZFacile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers10.1038/s41598-019-47543-42045-2322https://doaj.org/article/78f993e4b9704608b89959b0a957de452019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-47543-4https://doaj.org/toc/2045-2322Abstract We report a simple surface functionalization of glutathione-capped gold nanoclusters by hydrophobic ion pairing with alkylamine followed by a complete phase transfer to various organic solvents with maintained colloidal stability and photoluminescence properties. The described surface hydrophobication enables efficient encapsulation of gold nanoclusters into PLGA nanocarriers allowing their visualization inside cultured cells using confocal fluorescent microscopy. The simplicity and efficiency of the described protocols should extend the biomedical applications of these metallic nanoclusters as a fluorescent platform to label hydrophobic polymeric nanocarriers beyond conventional organic dyes.Alaaldin M. AlkilanyShrouq AlsotariMahmoud Y. AlkawareekSamer R. AbulateefehNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alaaldin M. Alkilany Shrouq Alsotari Mahmoud Y. Alkawareek Samer R. Abulateefeh Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers
description	Abstract We report a simple surface functionalization of glutathione-capped gold nanoclusters by hydrophobic ion pairing with alkylamine followed by a complete phase transfer to various organic solvents with maintained colloidal stability and photoluminescence properties. The described surface hydrophobication enables efficient encapsulation of gold nanoclusters into PLGA nanocarriers allowing their visualization inside cultured cells using confocal fluorescent microscopy. The simplicity and efficiency of the described protocols should extend the biomedical applications of these metallic nanoclusters as a fluorescent platform to label hydrophobic polymeric nanocarriers beyond conventional organic dyes.
format	article
author	Alaaldin M. Alkilany Shrouq Alsotari Mahmoud Y. Alkawareek Samer R. Abulateefeh
author_facet	Alaaldin M. Alkilany Shrouq Alsotari Mahmoud Y. Alkawareek Samer R. Abulateefeh
author_sort	Alaaldin M. Alkilany
title	Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers
title_short	Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers
title_full	Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers
title_fullStr	Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers
title_full_unstemmed	Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers
title_sort	facile hydrophobication of glutathione-protected gold nanoclusters and encapsulation into poly(lactide-co-glycolide) nanocarriers
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/78f993e4b9704608b89959b0a957de45
work_keys_str_mv	AT alaaldinmalkilany facilehydrophobicationofglutathioneprotectedgoldnanoclustersandencapsulationintopolylactidecoglycolidenanocarriers AT shrouqalsotari facilehydrophobicationofglutathioneprotectedgoldnanoclustersandencapsulationintopolylactidecoglycolidenanocarriers AT mahmoudyalkawareek facilehydrophobicationofglutathioneprotectedgoldnanoclustersandencapsulationintopolylactidecoglycolidenanocarriers AT samerrabulateefeh facilehydrophobicationofglutathioneprotectedgoldnanoclustersandencapsulationintopolylactidecoglycolidenanocarriers
_version_	1718388007337197568

Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers

Ejemplares similares