Social factors and leukocyte DNA methylation of repetitive sequences: the multi-ethnic study of atherosclerosis.

Epigenetic changes are a potential mechanism contributing to race/ethnic and socioeconomic disparities in health. However, there is scant evidence of the race/ethnic and socioeconomic patterning of epigenetic marks. We used data from the Multi-Ethnic Study of Atherosclerosis Stress Study (N = 988) t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Malavika A Subramanyam, Ana V Diez-Roux, J Richard Pilsner, Eduardo Villamor, Kathleen M Donohue, Yongmei Liu, Nancy S Jenny
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78fe2cf5f1c14f94813ff57076105374
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:78fe2cf5f1c14f94813ff57076105374
record_format	dspace
spelling	oai:doaj.org-article:78fe2cf5f1c14f94813ff570761053742021-11-18T08:02:16ZSocial factors and leukocyte DNA methylation of repetitive sequences: the multi-ethnic study of atherosclerosis.1932-620310.1371/journal.pone.0054018https://doaj.org/article/78fe2cf5f1c14f94813ff570761053742013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23320117/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Epigenetic changes are a potential mechanism contributing to race/ethnic and socioeconomic disparities in health. However, there is scant evidence of the race/ethnic and socioeconomic patterning of epigenetic marks. We used data from the Multi-Ethnic Study of Atherosclerosis Stress Study (N = 988) to describe age- and gender-independent associations of race/ethnicity and socioeconomic status (SES) with methylation of Alu and LINE-1 repetitive elements in leukocyte DNA. Mean Alu and Line 1 methylation in the full sample were 24% and 81% respectively. In multivariable linear regression models, African-Americans had 0.27% (p<0.01) and Hispanics 0.20% (p<0.05) lower Alu methylation than whites. In contrast, African-Americans had 0.41% (p<0.01) and Hispanics 0.39% (p<0.01) higher LINE-1 methylation than whites. These associations remained after adjustment for SES. In addition, a one standard deviation higher wealth was associated with 0.09% (p<0.01) higher Alu and 0.15% (p<0.01) lower LINE-1 methylation in age- and gender-adjusted models. Additional adjustment for race/ethnicity did not alter this pattern. No associations were observed with income, education or childhood SES. Our findings, from a large community-based sample, suggest that DNA methylation is socially patterned. Future research, including studies of gene-specific methylation, is needed to understand better the opposing associations of Alu and LINE-1 methylation with race/ethnicity and wealth as well as the extent to which small methylation changes in these sequences may influence disparities in health.Malavika A SubramanyamAna V Diez-RouxJ Richard PilsnerEduardo VillamorKathleen M DonohueYongmei LiuNancy S JennyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54018 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Malavika A Subramanyam Ana V Diez-Roux J Richard Pilsner Eduardo Villamor Kathleen M Donohue Yongmei Liu Nancy S Jenny Social factors and leukocyte DNA methylation of repetitive sequences: the multi-ethnic study of atherosclerosis.
description	Epigenetic changes are a potential mechanism contributing to race/ethnic and socioeconomic disparities in health. However, there is scant evidence of the race/ethnic and socioeconomic patterning of epigenetic marks. We used data from the Multi-Ethnic Study of Atherosclerosis Stress Study (N = 988) to describe age- and gender-independent associations of race/ethnicity and socioeconomic status (SES) with methylation of Alu and LINE-1 repetitive elements in leukocyte DNA. Mean Alu and Line 1 methylation in the full sample were 24% and 81% respectively. In multivariable linear regression models, African-Americans had 0.27% (p<0.01) and Hispanics 0.20% (p<0.05) lower Alu methylation than whites. In contrast, African-Americans had 0.41% (p<0.01) and Hispanics 0.39% (p<0.01) higher LINE-1 methylation than whites. These associations remained after adjustment for SES. In addition, a one standard deviation higher wealth was associated with 0.09% (p<0.01) higher Alu and 0.15% (p<0.01) lower LINE-1 methylation in age- and gender-adjusted models. Additional adjustment for race/ethnicity did not alter this pattern. No associations were observed with income, education or childhood SES. Our findings, from a large community-based sample, suggest that DNA methylation is socially patterned. Future research, including studies of gene-specific methylation, is needed to understand better the opposing associations of Alu and LINE-1 methylation with race/ethnicity and wealth as well as the extent to which small methylation changes in these sequences may influence disparities in health.
format	article
author	Malavika A Subramanyam Ana V Diez-Roux J Richard Pilsner Eduardo Villamor Kathleen M Donohue Yongmei Liu Nancy S Jenny
author_facet	Malavika A Subramanyam Ana V Diez-Roux J Richard Pilsner Eduardo Villamor Kathleen M Donohue Yongmei Liu Nancy S Jenny
author_sort	Malavika A Subramanyam
title	Social factors and leukocyte DNA methylation of repetitive sequences: the multi-ethnic study of atherosclerosis.
title_short	Social factors and leukocyte DNA methylation of repetitive sequences: the multi-ethnic study of atherosclerosis.
title_full	Social factors and leukocyte DNA methylation of repetitive sequences: the multi-ethnic study of atherosclerosis.
title_fullStr	Social factors and leukocyte DNA methylation of repetitive sequences: the multi-ethnic study of atherosclerosis.
title_full_unstemmed	Social factors and leukocyte DNA methylation of repetitive sequences: the multi-ethnic study of atherosclerosis.
title_sort	social factors and leukocyte dna methylation of repetitive sequences: the multi-ethnic study of atherosclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/78fe2cf5f1c14f94813ff57076105374
work_keys_str_mv	AT malavikaasubramanyam socialfactorsandleukocytednamethylationofrepetitivesequencesthemultiethnicstudyofatherosclerosis AT anavdiezroux socialfactorsandleukocytednamethylationofrepetitivesequencesthemultiethnicstudyofatherosclerosis AT jrichardpilsner socialfactorsandleukocytednamethylationofrepetitivesequencesthemultiethnicstudyofatherosclerosis AT eduardovillamor socialfactorsandleukocytednamethylationofrepetitivesequencesthemultiethnicstudyofatherosclerosis AT kathleenmdonohue socialfactorsandleukocytednamethylationofrepetitivesequencesthemultiethnicstudyofatherosclerosis AT yongmeiliu socialfactorsandleukocytednamethylationofrepetitivesequencesthemultiethnicstudyofatherosclerosis AT nancysjenny socialfactorsandleukocytednamethylationofrepetitivesequencesthemultiethnicstudyofatherosclerosis
_version_	1718422609857609728

Social factors and leukocyte DNA methylation of repetitive sequences: the multi-ethnic study of atherosclerosis.

Ejemplares similares