Biological responses to core–shell-structured Fe3O4@SiO2-NH2 nanoparticles in rats by a nuclear magnetic resonance-based metabonomic strategy

Biological responses to core–shell-structured Fe3O4@SiO2-NH2 nanoparticles in rats by a nuclear magnetic resonance-based metabonomic strategy

Zhongxue Yuan,1 Rui Xu,1 Jinquan Li,1 Yueli Chen,1 Binghui Wu,2 Jianghua Feng,1 Zhong Chen1 1Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, Fujian, China; 2State Key Laboratory for Physical Chemistry of Solid Surface,...

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Autores principales: Yuan ZX, Xu R, Li JQ, Chen YL, Wu BH, Feng JH, Chen Z
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
core-shell structure
biomedical nanoparticles
metabonomics
NMR
biological effects
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/790028c84599420faa05b2c11625795f
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spelling oai:doaj.org-article:790028c84599420faa05b2c11625795f2021-12-02T07:20:52ZBiological responses to core–shell-structured Fe3O4@SiO2-NH2 nanoparticles in rats by a nuclear magnetic resonance-based metabonomic strategy1178-2013https://doaj.org/article/790028c84599420faa05b2c11625795f2018-04-01T00:00:00Zhttps://www.dovepress.com/biological-responses-to-core-shell-structured-fe3o4sio2-nh2-nanopartic-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zhongxue Yuan,1 Rui Xu,1 Jinquan Li,1 Yueli Chen,1 Binghui Wu,2 Jianghua Feng,1 Zhong Chen1 1Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, Fujian, China; 2State Key Laboratory for Physical Chemistry of Solid Surface, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, China Background: Core–shell-structured nanoparticles (NPs) have attracted much scientific attention due to their promising potential in biomedical fields in recent years. However, their underlying mechanisms of action and potential adverse effects following administration remain unknown. Methods: In the present study, a 1H nuclear magnetic resonance-based metabonomic strategy was applied to investigate the metabolic consequences in rats following the intravenous administration of parent NPs of core–shell-structured nanoparticles, Fe3O4@SiO2-NH2 (Fe@Si) NPs. Results: Alterations reflected in plasma and urinary metabonomes indicated that Fe@Si NPs induced metabolic perturbation in choline, ketone-body, and amino-acid metabolism besides the common metabolic disorders in tricarboxylic acid cycle, lipids, and glycogen metabolism often induced by the exogenous agents. Additionally, intestinal flora metabolism and the urea cycle were also influenced by Fe@Si NP exposure. Time-dependent biological effects revealed obvious metabolic regression, dose-dependent biological effects implied different biochemical mechanisms between low- and high-dose Fe@Si NPs, and size-dependent biological effects provided potential windows for size optimization. Conclusion: Nuclear magnetic resonance-based metabonomic analysis helps in understanding the biological mechanisms of Fe@Si NPs, provides an identifiable ground for the selection of view windows, and further serves the clinical translation of Fe@Si NP-derived and -modified bioprobes or bioagents. Keywords: core–shell structure, biomedical nanoparticles, metabonomics, NMR, biological effectsYuan ZXXu RLi JQChen YLWu BHFeng JHChen ZDove Medical Pressarticlecore-shell structurebiomedical nanoparticlesmetabonomicsNMRbiological effectsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2447-2462 (2018)
institution DOAJ
collection DOAJ
language EN
topic core-shell structure
biomedical nanoparticles
metabonomics
NMR
biological effects
Medicine (General)
R5-920
spellingShingle core-shell structure
biomedical nanoparticles
metabonomics
NMR
biological effects
Medicine (General)
R5-920
Yuan ZX
Xu R
Li JQ
Chen YL
Wu BH
Feng JH
Chen Z
Biological responses to core–shell-structured Fe3O4@SiO2-NH2 nanoparticles in rats by a nuclear magnetic resonance-based metabonomic strategy
description Zhongxue Yuan,1 Rui Xu,1 Jinquan Li,1 Yueli Chen,1 Binghui Wu,2 Jianghua Feng,1 Zhong Chen1 1Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, Fujian, China; 2State Key Laboratory for Physical Chemistry of Solid Surface, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, China Background: Core–shell-structured nanoparticles (NPs) have attracted much scientific attention due to their promising potential in biomedical fields in recent years. However, their underlying mechanisms of action and potential adverse effects following administration remain unknown. Methods: In the present study, a 1H nuclear magnetic resonance-based metabonomic strategy was applied to investigate the metabolic consequences in rats following the intravenous administration of parent NPs of core–shell-structured nanoparticles, Fe3O4@SiO2-NH2 (Fe@Si) NPs. Results: Alterations reflected in plasma and urinary metabonomes indicated that Fe@Si NPs induced metabolic perturbation in choline, ketone-body, and amino-acid metabolism besides the common metabolic disorders in tricarboxylic acid cycle, lipids, and glycogen metabolism often induced by the exogenous agents. Additionally, intestinal flora metabolism and the urea cycle were also influenced by Fe@Si NP exposure. Time-dependent biological effects revealed obvious metabolic regression, dose-dependent biological effects implied different biochemical mechanisms between low- and high-dose Fe@Si NPs, and size-dependent biological effects provided potential windows for size optimization. Conclusion: Nuclear magnetic resonance-based metabonomic analysis helps in understanding the biological mechanisms of Fe@Si NPs, provides an identifiable ground for the selection of view windows, and further serves the clinical translation of Fe@Si NP-derived and -modified bioprobes or bioagents. Keywords: core–shell structure, biomedical nanoparticles, metabonomics, NMR, biological effects
format article
author Yuan ZX
Xu R
Li JQ
Chen YL
Wu BH
Feng JH
Chen Z
author_facet Yuan ZX
Xu R
Li JQ
Chen YL
Wu BH
Feng JH
Chen Z
author_sort Yuan ZX
title Biological responses to core–shell-structured Fe3O4@SiO2-NH2 nanoparticles in rats by a nuclear magnetic resonance-based metabonomic strategy
title_short Biological responses to core–shell-structured Fe3O4@SiO2-NH2 nanoparticles in rats by a nuclear magnetic resonance-based metabonomic strategy
title_full Biological responses to core–shell-structured Fe3O4@SiO2-NH2 nanoparticles in rats by a nuclear magnetic resonance-based metabonomic strategy
title_fullStr Biological responses to core–shell-structured Fe3O4@SiO2-NH2 nanoparticles in rats by a nuclear magnetic resonance-based metabonomic strategy
title_full_unstemmed Biological responses to core–shell-structured Fe3O4@SiO2-NH2 nanoparticles in rats by a nuclear magnetic resonance-based metabonomic strategy
title_sort biological responses to core–shell-structured fe3o4@sio2-nh2 nanoparticles in rats by a nuclear magnetic resonance-based metabonomic strategy
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/790028c84599420faa05b2c11625795f
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