Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial

Background: Few studies have examined the effect of seborrheic dermatitis (SD) and/or its consequent therapy on a patient’s quality of life. Itraconazole has been suggested as an effective therapy for severe SD but its impact on Quality of Life (QoL) in these patients has never been studied before....

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Autores principales:	Zaheer Abbas, Seyede Zahra Ghodsi, Robabeh Abedeni
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2016
Materias:	itraconazole seborrheic dermatitis quality of life Malassezia Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/7904c2cf8fa04a7fb3710ba2a1d06b3a
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spelling	oai:doaj.org-article:7904c2cf8fa04a7fb3710ba2a1d06b3a2021-11-17T08:31:13ZEffect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial10.5826/dpc.0603a042160-9381https://doaj.org/article/7904c2cf8fa04a7fb3710ba2a1d06b3a2016-07-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/92https://doaj.org/toc/2160-9381 Background: Few studies have examined the effect of seborrheic dermatitis (SD) and/or its consequent therapy on a patient’s quality of life. Itraconazole has been suggested as an effective therapy for severe SD but its impact on Quality of Life (QoL) in these patients has never been studied before. Objective: The study aimed to verify the efficacy of the itraconazole on the quality of life in patients with moderate to severe SD. Methods: A randomized, double-blind, placebo controlled trial was planned to describe the effect of SD per se on QoL and to determine the impact of oral itraconazole or placebo on QoL of SD patients. Sixty-eight patients with moderate to severe SD participated in the study to receive either itraconazole or placebo. Dermatology Life Quality Index was used to evaluate their quality of life before and after treatment. Itraconazole 200 mg/daily or placebo was prescribed for one week and then the first two days of every month for the following three months. Fifty-seven patients completed the study. Results: Significant improvement was observed in QoL of both itraconazole and placebo groups, but itraconazole group showed significantly higher improvement as compared to placebo (p=0.001). QoL was impaired significantly with high disease severity (p=0.002) and facial involvement (p=0.017). Conclusions: Itraconazole significantly improves the QoL in patients with moderate to severe SD. Zaheer AbbasSeyede Zahra GhodsiRobabeh AbedeniMattioli1885articleitraconazoleseborrheic dermatitisquality of lifeMalasseziaDermatologyRL1-803ENDermatology Practical & Conceptual (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	itraconazole seborrheic dermatitis quality of life Malassezia Dermatology RL1-803
spellingShingle	itraconazole seborrheic dermatitis quality of life Malassezia Dermatology RL1-803 Zaheer Abbas Seyede Zahra Ghodsi Robabeh Abedeni Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial
description	Background: Few studies have examined the effect of seborrheic dermatitis (SD) and/or its consequent therapy on a patient’s quality of life. Itraconazole has been suggested as an effective therapy for severe SD but its impact on Quality of Life (QoL) in these patients has never been studied before. Objective: The study aimed to verify the efficacy of the itraconazole on the quality of life in patients with moderate to severe SD. Methods: A randomized, double-blind, placebo controlled trial was planned to describe the effect of SD per se on QoL and to determine the impact of oral itraconazole or placebo on QoL of SD patients. Sixty-eight patients with moderate to severe SD participated in the study to receive either itraconazole or placebo. Dermatology Life Quality Index was used to evaluate their quality of life before and after treatment. Itraconazole 200 mg/daily or placebo was prescribed for one week and then the first two days of every month for the following three months. Fifty-seven patients completed the study. Results: Significant improvement was observed in QoL of both itraconazole and placebo groups, but itraconazole group showed significantly higher improvement as compared to placebo (p=0.001). QoL was impaired significantly with high disease severity (p=0.002) and facial involvement (p=0.017). Conclusions: Itraconazole significantly improves the QoL in patients with moderate to severe SD.
format	article
author	Zaheer Abbas Seyede Zahra Ghodsi Robabeh Abedeni
author_facet	Zaheer Abbas Seyede Zahra Ghodsi Robabeh Abedeni
author_sort	Zaheer Abbas
title	Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial
title_short	Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial
title_full	Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial
title_fullStr	Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial
title_full_unstemmed	Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial
title_sort	effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial
publisher	Mattioli1885
publishDate	2016
url	https://doaj.org/article/7904c2cf8fa04a7fb3710ba2a1d06b3a
work_keys_str_mv	AT zaheerabbas effectofitraconazoleonthequalityoflifeinpatientswithmoderatetosevereseborrheicdermatitisarandomizedplacebocontrolledtrial AT seyedezahraghodsi effectofitraconazoleonthequalityoflifeinpatientswithmoderatetosevereseborrheicdermatitisarandomizedplacebocontrolledtrial AT robabehabedeni effectofitraconazoleonthequalityoflifeinpatientswithmoderatetosevereseborrheicdermatitisarandomizedplacebocontrolledtrial
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Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial

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