Promotion of homology-directed DNA repair by polyamines

The maintenance polyamines homeostasis is important for cell growth, and several cancers harbor elevated levels of polyamines that may contribute to sustained proliferative potential. Here the authors demonstrate that polyamines participate in DNA double-strand break repair through the stimulation o...

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Autores principales:	Chih-Ying Lee, Guan-Chin Su, Wen-Yen Huang, Min-Yu Ko, Hsin-Yi Yeh, Geen-Dong Chang, Sung-Jan Lin, Peter Chi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7905654691784a7b98c5c9e821361d5d
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spelling	oai:doaj.org-article:7905654691784a7b98c5c9e821361d5d2021-12-02T14:39:36ZPromotion of homology-directed DNA repair by polyamines10.1038/s41467-018-08011-12041-1723https://doaj.org/article/7905654691784a7b98c5c9e821361d5d2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08011-1https://doaj.org/toc/2041-1723The maintenance polyamines homeostasis is important for cell growth, and several cancers harbor elevated levels of polyamines that may contribute to sustained proliferative potential. Here the authors demonstrate that polyamines participate in DNA double-strand break repair through the stimulation of RAD51-mediated homologous DNA pairing and strand exchange.Chih-Ying LeeGuan-Chin SuWen-Yen HuangMin-Yu KoHsin-Yi YehGeen-Dong ChangSung-Jan LinPeter ChiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chih-Ying Lee Guan-Chin Su Wen-Yen Huang Min-Yu Ko Hsin-Yi Yeh Geen-Dong Chang Sung-Jan Lin Peter Chi Promotion of homology-directed DNA repair by polyamines
description	The maintenance polyamines homeostasis is important for cell growth, and several cancers harbor elevated levels of polyamines that may contribute to sustained proliferative potential. Here the authors demonstrate that polyamines participate in DNA double-strand break repair through the stimulation of RAD51-mediated homologous DNA pairing and strand exchange.
format	article
author	Chih-Ying Lee Guan-Chin Su Wen-Yen Huang Min-Yu Ko Hsin-Yi Yeh Geen-Dong Chang Sung-Jan Lin Peter Chi
author_facet	Chih-Ying Lee Guan-Chin Su Wen-Yen Huang Min-Yu Ko Hsin-Yi Yeh Geen-Dong Chang Sung-Jan Lin Peter Chi
author_sort	Chih-Ying Lee
title	Promotion of homology-directed DNA repair by polyamines
title_short	Promotion of homology-directed DNA repair by polyamines
title_full	Promotion of homology-directed DNA repair by polyamines
title_fullStr	Promotion of homology-directed DNA repair by polyamines
title_full_unstemmed	Promotion of homology-directed DNA repair by polyamines
title_sort	promotion of homology-directed dna repair by polyamines
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7905654691784a7b98c5c9e821361d5d
work_keys_str_mv	AT chihyinglee promotionofhomologydirecteddnarepairbypolyamines AT guanchinsu promotionofhomologydirecteddnarepairbypolyamines AT wenyenhuang promotionofhomologydirecteddnarepairbypolyamines AT minyuko promotionofhomologydirecteddnarepairbypolyamines AT hsinyiyeh promotionofhomologydirecteddnarepairbypolyamines AT geendongchang promotionofhomologydirecteddnarepairbypolyamines AT sungjanlin promotionofhomologydirecteddnarepairbypolyamines AT peterchi promotionofhomologydirecteddnarepairbypolyamines
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Promotion of homology-directed DNA repair by polyamines

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