Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code

The anticodon loops of almost all tRNAs contain modifications known to be important for their function. Here the authors use crystallography to provide new mechanistic insights into how the modification at the wobble position of the E. coli tRNALysUUUassists in discrimination between cognate and nea...

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Autores principales:	Alexey Rozov, Natalia Demeshkina, Iskander Khusainov, Eric Westhof, Marat Yusupov, Gulnara Yusupova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/79069a8223ce49d8a433c23959c69e98
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spelling	oai:doaj.org-article:79069a8223ce49d8a433c23959c69e982021-12-02T17:32:51ZNovel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code10.1038/ncomms104572041-1723https://doaj.org/article/79069a8223ce49d8a433c23959c69e982016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10457https://doaj.org/toc/2041-1723The anticodon loops of almost all tRNAs contain modifications known to be important for their function. Here the authors use crystallography to provide new mechanistic insights into how the modification at the wobble position of the E. coli tRNALysUUUassists in discrimination between cognate and near-cognate codons.Alexey RozovNatalia DemeshkinaIskander KhusainovEric WesthofMarat YusupovGulnara YusupovaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexey Rozov Natalia Demeshkina Iskander Khusainov Eric Westhof Marat Yusupov Gulnara Yusupova Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code
description	The anticodon loops of almost all tRNAs contain modifications known to be important for their function. Here the authors use crystallography to provide new mechanistic insights into how the modification at the wobble position of the E. coli tRNALysUUUassists in discrimination between cognate and near-cognate codons.
format	article
author	Alexey Rozov Natalia Demeshkina Iskander Khusainov Eric Westhof Marat Yusupov Gulnara Yusupova
author_facet	Alexey Rozov Natalia Demeshkina Iskander Khusainov Eric Westhof Marat Yusupov Gulnara Yusupova
author_sort	Alexey Rozov
title	Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code
title_short	Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code
title_full	Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code
title_fullStr	Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code
title_full_unstemmed	Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code
title_sort	novel base-pairing interactions at the trna wobble position crucial for accurate reading of the genetic code
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/79069a8223ce49d8a433c23959c69e98
work_keys_str_mv	AT alexeyrozov novelbasepairinginteractionsatthetrnawobblepositioncrucialforaccuratereadingofthegeneticcode AT nataliademeshkina novelbasepairinginteractionsatthetrnawobblepositioncrucialforaccuratereadingofthegeneticcode AT iskanderkhusainov novelbasepairinginteractionsatthetrnawobblepositioncrucialforaccuratereadingofthegeneticcode AT ericwesthof novelbasepairinginteractionsatthetrnawobblepositioncrucialforaccuratereadingofthegeneticcode AT maratyusupov novelbasepairinginteractionsatthetrnawobblepositioncrucialforaccuratereadingofthegeneticcode AT gulnarayusupova novelbasepairinginteractionsatthetrnawobblepositioncrucialforaccuratereadingofthegeneticcode
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Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code

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