Evolution and pathogenicity of H6 avian influenza viruses isolated from Southern China during 2011 to 2017 in mice and chickens

Abstract H6 subtype avian influenza viruses spread widely in birds and pose potential threats to poultry and mammals, even to human beings. In this study, the evolution and pathogenicity of H6 AIVs isolated in live poultry markets from 2011 to 2017 were investigated. These H6 isolates were reassorta...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Weishan Lin, Hongrui Cui, Qiaoyang Teng, Luzhao Li, Ying Shi, Xuesong Li, Jianmei Yang, Qinfang Liu, Junliang Deng, Zejun Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/79082a0ae0324d5daa8c6b914ba9c909
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:79082a0ae0324d5daa8c6b914ba9c909
record_format	dspace
spelling	oai:doaj.org-article:79082a0ae0324d5daa8c6b914ba9c9092021-12-02T15:10:19ZEvolution and pathogenicity of H6 avian influenza viruses isolated from Southern China during 2011 to 2017 in mice and chickens10.1038/s41598-020-76541-02045-2322https://doaj.org/article/79082a0ae0324d5daa8c6b914ba9c9092020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-76541-0https://doaj.org/toc/2045-2322Abstract H6 subtype avian influenza viruses spread widely in birds and pose potential threats to poultry and mammals, even to human beings. In this study, the evolution and pathogenicity of H6 AIVs isolated in live poultry markets from 2011 to 2017 were investigated. These H6 isolates were reassortant with other subtypes of influenza virus with increasing genomic diversity. However, no predominant genotype was found during this period. All of the H6N2 and most of the H6N6 isolates replicated efficiently in lungs of inoculated mice without prior adaptation. All of the H6N2 and two H6N6 isolates replicated efficiently in nasal turbinates of inoculated mice, which suggested the H6N2 viruses were more adaptive to the upper respiratory tract of mice than the H6N6 viruses. One of H6N2 virus caused systemic infection in one out of three inoculated mice, which indicated that H6 avian influenza virus, especially the H6N2 viruses posed a potential threat to mammals. Five H6 strains selected from different genotypes caused no clinical signs to inoculated chickens, and their replication were limited in chickens since the viruses have been detected only from a few tissues or swabs at low titers. Our study strongly suggests that the H6 avian influenza virus isolated from live poultry markets pose potential threat to mammals.Weishan LinHongrui CuiQiaoyang TengLuzhao LiYing ShiXuesong LiJianmei YangQinfang LiuJunliang DengZejun LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Weishan Lin Hongrui Cui Qiaoyang Teng Luzhao Li Ying Shi Xuesong Li Jianmei Yang Qinfang Liu Junliang Deng Zejun Li Evolution and pathogenicity of H6 avian influenza viruses isolated from Southern China during 2011 to 2017 in mice and chickens
description	Abstract H6 subtype avian influenza viruses spread widely in birds and pose potential threats to poultry and mammals, even to human beings. In this study, the evolution and pathogenicity of H6 AIVs isolated in live poultry markets from 2011 to 2017 were investigated. These H6 isolates were reassortant with other subtypes of influenza virus with increasing genomic diversity. However, no predominant genotype was found during this period. All of the H6N2 and most of the H6N6 isolates replicated efficiently in lungs of inoculated mice without prior adaptation. All of the H6N2 and two H6N6 isolates replicated efficiently in nasal turbinates of inoculated mice, which suggested the H6N2 viruses were more adaptive to the upper respiratory tract of mice than the H6N6 viruses. One of H6N2 virus caused systemic infection in one out of three inoculated mice, which indicated that H6 avian influenza virus, especially the H6N2 viruses posed a potential threat to mammals. Five H6 strains selected from different genotypes caused no clinical signs to inoculated chickens, and their replication were limited in chickens since the viruses have been detected only from a few tissues or swabs at low titers. Our study strongly suggests that the H6 avian influenza virus isolated from live poultry markets pose potential threat to mammals.
format	article
author	Weishan Lin Hongrui Cui Qiaoyang Teng Luzhao Li Ying Shi Xuesong Li Jianmei Yang Qinfang Liu Junliang Deng Zejun Li
author_facet	Weishan Lin Hongrui Cui Qiaoyang Teng Luzhao Li Ying Shi Xuesong Li Jianmei Yang Qinfang Liu Junliang Deng Zejun Li
author_sort	Weishan Lin
title	Evolution and pathogenicity of H6 avian influenza viruses isolated from Southern China during 2011 to 2017 in mice and chickens
title_short	Evolution and pathogenicity of H6 avian influenza viruses isolated from Southern China during 2011 to 2017 in mice and chickens
title_full	Evolution and pathogenicity of H6 avian influenza viruses isolated from Southern China during 2011 to 2017 in mice and chickens
title_fullStr	Evolution and pathogenicity of H6 avian influenza viruses isolated from Southern China during 2011 to 2017 in mice and chickens
title_full_unstemmed	Evolution and pathogenicity of H6 avian influenza viruses isolated from Southern China during 2011 to 2017 in mice and chickens
title_sort	evolution and pathogenicity of h6 avian influenza viruses isolated from southern china during 2011 to 2017 in mice and chickens
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/79082a0ae0324d5daa8c6b914ba9c909
work_keys_str_mv	AT weishanlin evolutionandpathogenicityofh6avianinfluenzavirusesisolatedfromsouthernchinaduring2011to2017inmiceandchickens AT hongruicui evolutionandpathogenicityofh6avianinfluenzavirusesisolatedfromsouthernchinaduring2011to2017inmiceandchickens AT qiaoyangteng evolutionandpathogenicityofh6avianinfluenzavirusesisolatedfromsouthernchinaduring2011to2017inmiceandchickens AT luzhaoli evolutionandpathogenicityofh6avianinfluenzavirusesisolatedfromsouthernchinaduring2011to2017inmiceandchickens AT yingshi evolutionandpathogenicityofh6avianinfluenzavirusesisolatedfromsouthernchinaduring2011to2017inmiceandchickens AT xuesongli evolutionandpathogenicityofh6avianinfluenzavirusesisolatedfromsouthernchinaduring2011to2017inmiceandchickens AT jianmeiyang evolutionandpathogenicityofh6avianinfluenzavirusesisolatedfromsouthernchinaduring2011to2017inmiceandchickens AT qinfangliu evolutionandpathogenicityofh6avianinfluenzavirusesisolatedfromsouthernchinaduring2011to2017inmiceandchickens AT junliangdeng evolutionandpathogenicityofh6avianinfluenzavirusesisolatedfromsouthernchinaduring2011to2017inmiceandchickens AT zejunli evolutionandpathogenicityofh6avianinfluenzavirusesisolatedfromsouthernchinaduring2011to2017inmiceandchickens
_version_	1718387698883887104

Evolution and pathogenicity of H6 avian influenza viruses isolated from Southern China during 2011 to 2017 in mice and chickens

Ejemplares similares