Endocannabinoid Modulation of Stimulus-Specific Adaptation in Inferior Colliculus Neurons of the Rat

Abstract Cannabinoid receptors (CBRs) are widely distributed in the brain, including the inferior colliculus (IC). Here, we aim to study whether endocannabinoids influence a specific type of neuronal adaptation, namely, stimulus-specific adaptation (SSA) found in some IC neurons. SSA is important be...

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Autores principales:	C. Valdés-Baizabal, G. G. Parras, Y. A. Ayala, M. S. Malmierca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/790d1fc046164b418d15e622bfbc5e69
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spelling	oai:doaj.org-article:790d1fc046164b418d15e622bfbc5e692021-12-02T11:40:13ZEndocannabinoid Modulation of Stimulus-Specific Adaptation in Inferior Colliculus Neurons of the Rat10.1038/s41598-017-07460-w2045-2322https://doaj.org/article/790d1fc046164b418d15e622bfbc5e692017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07460-whttps://doaj.org/toc/2045-2322Abstract Cannabinoid receptors (CBRs) are widely distributed in the brain, including the inferior colliculus (IC). Here, we aim to study whether endocannabinoids influence a specific type of neuronal adaptation, namely, stimulus-specific adaptation (SSA) found in some IC neurons. SSA is important because it has been found as early as the level of the midbrain and therefore it may be a neuronal correlate of early indices of deviance detection. Furthermore, recent studies have demonstrated a direct link between SSA and MMN, that is widely used as an outcome measure in a variety of human neurodegenerative disorders. SSA is considered a form of short-term plasticity, and CBRs have been shown to play a role in short-term neural plasticity. Therefore, it is reasonable to hypothesize that endocannabinoids may play a role in the generation or modulation of SSA. We recorded single units in the IC under an oddball paradigm stimulation. The results demonstrate that cannabinoid agonists lead to a reduction in the neuronal adaptation. This change is due to a differential increase of the neuronal firing rate to the standard tone alone. Furthermore, we show that the effect is mediated by the cannabinoid receptor 1 (CBR1). Thus, cannabinoid agonists down-modulate SSA in IC neurons.C. Valdés-BaizabalG. G. ParrasY. A. AyalaM. S. MalmiercaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q C. Valdés-Baizabal G. G. Parras Y. A. Ayala M. S. Malmierca Endocannabinoid Modulation of Stimulus-Specific Adaptation in Inferior Colliculus Neurons of the Rat
description	Abstract Cannabinoid receptors (CBRs) are widely distributed in the brain, including the inferior colliculus (IC). Here, we aim to study whether endocannabinoids influence a specific type of neuronal adaptation, namely, stimulus-specific adaptation (SSA) found in some IC neurons. SSA is important because it has been found as early as the level of the midbrain and therefore it may be a neuronal correlate of early indices of deviance detection. Furthermore, recent studies have demonstrated a direct link between SSA and MMN, that is widely used as an outcome measure in a variety of human neurodegenerative disorders. SSA is considered a form of short-term plasticity, and CBRs have been shown to play a role in short-term neural plasticity. Therefore, it is reasonable to hypothesize that endocannabinoids may play a role in the generation or modulation of SSA. We recorded single units in the IC under an oddball paradigm stimulation. The results demonstrate that cannabinoid agonists lead to a reduction in the neuronal adaptation. This change is due to a differential increase of the neuronal firing rate to the standard tone alone. Furthermore, we show that the effect is mediated by the cannabinoid receptor 1 (CBR1). Thus, cannabinoid agonists down-modulate SSA in IC neurons.
format	article
author	C. Valdés-Baizabal G. G. Parras Y. A. Ayala M. S. Malmierca
author_facet	C. Valdés-Baizabal G. G. Parras Y. A. Ayala M. S. Malmierca
author_sort	C. Valdés-Baizabal
title	Endocannabinoid Modulation of Stimulus-Specific Adaptation in Inferior Colliculus Neurons of the Rat
title_short	Endocannabinoid Modulation of Stimulus-Specific Adaptation in Inferior Colliculus Neurons of the Rat
title_full	Endocannabinoid Modulation of Stimulus-Specific Adaptation in Inferior Colliculus Neurons of the Rat
title_fullStr	Endocannabinoid Modulation of Stimulus-Specific Adaptation in Inferior Colliculus Neurons of the Rat
title_full_unstemmed	Endocannabinoid Modulation of Stimulus-Specific Adaptation in Inferior Colliculus Neurons of the Rat
title_sort	endocannabinoid modulation of stimulus-specific adaptation in inferior colliculus neurons of the rat
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/790d1fc046164b418d15e622bfbc5e69
work_keys_str_mv	AT cvaldesbaizabal endocannabinoidmodulationofstimulusspecificadaptationininferiorcolliculusneuronsoftherat AT ggparras endocannabinoidmodulationofstimulusspecificadaptationininferiorcolliculusneuronsoftherat AT yaayala endocannabinoidmodulationofstimulusspecificadaptationininferiorcolliculusneuronsoftherat AT msmalmierca endocannabinoidmodulationofstimulusspecificadaptationininferiorcolliculusneuronsoftherat
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Endocannabinoid Modulation of Stimulus-Specific Adaptation in Inferior Colliculus Neurons of the Rat

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