Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
Ubiquitin and ubiquitin-like modifiers such as SUMO play important roles in several cellular pathways that can become deregulated in cancer. Here the authors describe the structural basis for inhibition of SUMO E1 ligase by the small molecule COH000.
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2018
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oai:doaj.org-article:790d42b1a88b44e08307e39d6b2a360c2021-12-02T16:50:05ZMolecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme10.1038/s41467-018-07015-12041-1723https://doaj.org/article/790d42b1a88b44e08307e39d6b2a360c2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07015-1https://doaj.org/toc/2041-1723Ubiquitin and ubiquitin-like modifiers such as SUMO play important roles in several cellular pathways that can become deregulated in cancer. Here the authors describe the structural basis for inhibition of SUMO E1 ligase by the small molecule COH000.Zongyang LvLingmin YuanJames H. AtkisonKatelyn M. WilliamsRamir VegaE. Hampton SessionsDaniela B. DivlianskaChristopher DaviesYuan ChenShaun K. OlsenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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Science Q Zongyang Lv Lingmin Yuan James H. Atkison Katelyn M. Williams Ramir Vega E. Hampton Sessions Daniela B. Divlianska Christopher Davies Yuan Chen Shaun K. Olsen Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme |
description |
Ubiquitin and ubiquitin-like modifiers such as SUMO play important roles in several cellular pathways that can become deregulated in cancer. Here the authors describe the structural basis for inhibition of SUMO E1 ligase by the small molecule COH000. |
format |
article |
author |
Zongyang Lv Lingmin Yuan James H. Atkison Katelyn M. Williams Ramir Vega E. Hampton Sessions Daniela B. Divlianska Christopher Davies Yuan Chen Shaun K. Olsen |
author_facet |
Zongyang Lv Lingmin Yuan James H. Atkison Katelyn M. Williams Ramir Vega E. Hampton Sessions Daniela B. Divlianska Christopher Davies Yuan Chen Shaun K. Olsen |
author_sort |
Zongyang Lv |
title |
Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme |
title_short |
Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme |
title_full |
Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme |
title_fullStr |
Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme |
title_full_unstemmed |
Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme |
title_sort |
molecular mechanism of a covalent allosteric inhibitor of sumo e1 activating enzyme |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/790d42b1a88b44e08307e39d6b2a360c |
work_keys_str_mv |
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1718383106656829440 |