Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

Ubiquitin and ubiquitin-like modifiers such as SUMO play important roles in several cellular pathways that can become deregulated in cancer. Here the authors describe the structural basis for inhibition of SUMO E1 ligase by the small molecule COH000.

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Auteurs principaux: Zongyang Lv, Lingmin Yuan, James H. Atkison, Katelyn M. Williams, Ramir Vega, E. Hampton Sessions, Daniela B. Divlianska, Christopher Davies, Yuan Chen, Shaun K. Olsen
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Langue:EN
Publié: Nature Portfolio 2018
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spelling oai:doaj.org-article:790d42b1a88b44e08307e39d6b2a360c2021-12-02T16:50:05ZMolecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme10.1038/s41467-018-07015-12041-1723https://doaj.org/article/790d42b1a88b44e08307e39d6b2a360c2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07015-1https://doaj.org/toc/2041-1723Ubiquitin and ubiquitin-like modifiers such as SUMO play important roles in several cellular pathways that can become deregulated in cancer. Here the authors describe the structural basis for inhibition of SUMO E1 ligase by the small molecule COH000.Zongyang LvLingmin YuanJames H. AtkisonKatelyn M. WilliamsRamir VegaE. Hampton SessionsDaniela B. DivlianskaChristopher DaviesYuan ChenShaun K. OlsenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zongyang Lv
Lingmin Yuan
James H. Atkison
Katelyn M. Williams
Ramir Vega
E. Hampton Sessions
Daniela B. Divlianska
Christopher Davies
Yuan Chen
Shaun K. Olsen
Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
description Ubiquitin and ubiquitin-like modifiers such as SUMO play important roles in several cellular pathways that can become deregulated in cancer. Here the authors describe the structural basis for inhibition of SUMO E1 ligase by the small molecule COH000.
format article
author Zongyang Lv
Lingmin Yuan
James H. Atkison
Katelyn M. Williams
Ramir Vega
E. Hampton Sessions
Daniela B. Divlianska
Christopher Davies
Yuan Chen
Shaun K. Olsen
author_facet Zongyang Lv
Lingmin Yuan
James H. Atkison
Katelyn M. Williams
Ramir Vega
E. Hampton Sessions
Daniela B. Divlianska
Christopher Davies
Yuan Chen
Shaun K. Olsen
author_sort Zongyang Lv
title Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
title_short Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
title_full Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
title_fullStr Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
title_full_unstemmed Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
title_sort molecular mechanism of a covalent allosteric inhibitor of sumo e1 activating enzyme
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/790d42b1a88b44e08307e39d6b2a360c
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