Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

Ubiquitin and ubiquitin-like modifiers such as SUMO play important roles in several cellular pathways that can become deregulated in cancer. Here the authors describe the structural basis for inhibition of SUMO E1 ligase by the small molecule COH000.

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Auteurs principaux:	Zongyang Lv, Lingmin Yuan, James H. Atkison, Katelyn M. Williams, Ramir Vega, E. Hampton Sessions, Daniela B. Divlianska, Christopher Davies, Yuan Chen, Shaun K. Olsen
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/790d42b1a88b44e08307e39d6b2a360c
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spelling	oai:doaj.org-article:790d42b1a88b44e08307e39d6b2a360c2021-12-02T16:50:05ZMolecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme10.1038/s41467-018-07015-12041-1723https://doaj.org/article/790d42b1a88b44e08307e39d6b2a360c2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07015-1https://doaj.org/toc/2041-1723Ubiquitin and ubiquitin-like modifiers such as SUMO play important roles in several cellular pathways that can become deregulated in cancer. Here the authors describe the structural basis for inhibition of SUMO E1 ligase by the small molecule COH000.Zongyang LvLingmin YuanJames H. AtkisonKatelyn M. WilliamsRamir VegaE. Hampton SessionsDaniela B. DivlianskaChristopher DaviesYuan ChenShaun K. OlsenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zongyang Lv Lingmin Yuan James H. Atkison Katelyn M. Williams Ramir Vega E. Hampton Sessions Daniela B. Divlianska Christopher Davies Yuan Chen Shaun K. Olsen Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
description	Ubiquitin and ubiquitin-like modifiers such as SUMO play important roles in several cellular pathways that can become deregulated in cancer. Here the authors describe the structural basis for inhibition of SUMO E1 ligase by the small molecule COH000.
format	article
author	Zongyang Lv Lingmin Yuan James H. Atkison Katelyn M. Williams Ramir Vega E. Hampton Sessions Daniela B. Divlianska Christopher Davies Yuan Chen Shaun K. Olsen
author_facet	Zongyang Lv Lingmin Yuan James H. Atkison Katelyn M. Williams Ramir Vega E. Hampton Sessions Daniela B. Divlianska Christopher Davies Yuan Chen Shaun K. Olsen
author_sort	Zongyang Lv
title	Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
title_short	Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
title_full	Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
title_fullStr	Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
title_full_unstemmed	Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
title_sort	molecular mechanism of a covalent allosteric inhibitor of sumo e1 activating enzyme
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/790d42b1a88b44e08307e39d6b2a360c
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_version_	1718383106656829440

Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

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