Once-daily pramipexole for the treatment of early and advanced idiopathic Parkinson’s disease: implications for patients
Angelo Antonini¹, Daniela Calandrella²¹Department for Parkinson’s Disease, IRCSS San Camillo, Venice, Italy; ²Department for Parkinson’s Disease, Clinic San Pio X, Milan, ItalyAbstract: Immediate-release (IR) pramipexole...
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2011
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/790fd554961049eb947f9d633128169f |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:790fd554961049eb947f9d633128169f |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:790fd554961049eb947f9d633128169f2021-12-02T06:49:28ZOnce-daily pramipexole for the treatment of early and advanced idiopathic Parkinson’s disease: implications for patients1176-63281178-2021https://doaj.org/article/790fd554961049eb947f9d633128169f2011-05-01T00:00:00Zhttp://www.dovepress.com/once-daily-pramipexole-for-the-treatment-of-early-and-advanced-idiopat-a7459https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Angelo Antonini¹, Daniela Calandrella²¹Department for Parkinson’s Disease, IRCSS San Camillo, Venice, Italy; ²Department for Parkinson’s Disease, Clinic San Pio X, Milan, ItalyAbstract: Immediate-release (IR) pramipexole is indicated for the symptomatic treatment of idiopathic Parkinson’s disease (PD), either alone (without levodopa) or in combination with levodopa, that is, during the entire progress of disease up to the advanced stage. It is also currently indicated for the treatment of moderate-to-severe primary restless legs syndrome (RLS). An extended-release (ER) formulation of pramipexole has been developed to allow a once-daily formulation and to provide more stable dopaminergic stimulation. This review summarized the pharmacokinetic profile of pramipexole for both the IR and ER formulations, and discussed the role of pramipexole in the management of early and advanced PD. The introduction of a once-daily formulation of pramipexole poses significant potential advantages for patients and this is reflected by relatively stable plasma levels. The most obvious benefit is convenience of use and better adherence to treatment schedule. Additional advantages may be represented by the opportunity to provide continuous drug delivery in a fashion that could potentially help minimize dyskinesia risk if the drug is used early in the disease course.Keywords: advanced Parkinson’s disease, continuous drug delivery, early Parkinson’s disease, extended release, immediate release, pramipexoleAntonini ACalandrella DDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2011, Iss Issue 1, Pp 297-302 (2011) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Antonini A Calandrella D Once-daily pramipexole for the treatment of early and advanced idiopathic Parkinson’s disease: implications for patients |
| description |
Angelo Antonini¹, Daniela Calandrella²¹Department for Parkinson’s Disease, IRCSS San Camillo, Venice, Italy; ²Department for Parkinson’s Disease, Clinic San Pio X, Milan, ItalyAbstract: Immediate-release (IR) pramipexole is indicated for the symptomatic treatment of idiopathic Parkinson’s disease (PD), either alone (without levodopa) or in combination with levodopa, that is, during the entire progress of disease up to the advanced stage. It is also currently indicated for the treatment of moderate-to-severe primary restless legs syndrome (RLS). An extended-release (ER) formulation of pramipexole has been developed to allow a once-daily formulation and to provide more stable dopaminergic stimulation. This review summarized the pharmacokinetic profile of pramipexole for both the IR and ER formulations, and discussed the role of pramipexole in the management of early and advanced PD. The introduction of a once-daily formulation of pramipexole poses significant potential advantages for patients and this is reflected by relatively stable plasma levels. The most obvious benefit is convenience of use and better adherence to treatment schedule. Additional advantages may be represented by the opportunity to provide continuous drug delivery in a fashion that could potentially help minimize dyskinesia risk if the drug is used early in the disease course.Keywords: advanced Parkinson’s disease, continuous drug delivery, early Parkinson’s disease, extended release, immediate release, pramipexole |
| format |
article |
| author |
Antonini A Calandrella D |
| author_facet |
Antonini A Calandrella D |
| author_sort |
Antonini A |
| title |
Once-daily pramipexole for the treatment of early and advanced idiopathic Parkinson’s disease: implications for patients |
| title_short |
Once-daily pramipexole for the treatment of early and advanced idiopathic Parkinson’s disease: implications for patients |
| title_full |
Once-daily pramipexole for the treatment of early and advanced idiopathic Parkinson’s disease: implications for patients |
| title_fullStr |
Once-daily pramipexole for the treatment of early and advanced idiopathic Parkinson’s disease: implications for patients |
| title_full_unstemmed |
Once-daily pramipexole for the treatment of early and advanced idiopathic Parkinson’s disease: implications for patients |
| title_sort |
once-daily pramipexole for the treatment of early and advanced idiopathic parkinson’s disease: implications for patients |
| publisher |
Dove Medical Press |
| publishDate |
2011 |
| url |
https://doaj.org/article/790fd554961049eb947f9d633128169f |
| work_keys_str_mv |
AT antoninia oncedailypramipexoleforthetreatmentofearlyandadvancedidiopathicparkinsonamprsquosdiseaseimplicationsforpatients AT calandrellad oncedailypramipexoleforthetreatmentofearlyandadvancedidiopathicparkinsonamprsquosdiseaseimplicationsforpatients |
| _version_ |
1718399698047336448 |