Switching the activity of Cas12a using guide RNA strand displacement circuits

Cas12a is a useful alternative to Cas9 for genome editing and regulation. Here the authors design strand displacement gRNAs that can add functionality to Cas12a by acting as multi-input logic gates.

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Detalles Bibliográficos
Autores principales:	Lukas Oesinghaus, Friedrich C. Simmel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/79110551716e4defa6c6b1044bdfa7e0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:79110551716e4defa6c6b1044bdfa7e02021-12-02T16:58:27ZSwitching the activity of Cas12a using guide RNA strand displacement circuits10.1038/s41467-019-09953-w2041-1723https://doaj.org/article/79110551716e4defa6c6b1044bdfa7e02019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09953-whttps://doaj.org/toc/2041-1723Cas12a is a useful alternative to Cas9 for genome editing and regulation. Here the authors design strand displacement gRNAs that can add functionality to Cas12a by acting as multi-input logic gates.Lukas OesinghausFriedrich C. SimmelNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lukas Oesinghaus Friedrich C. Simmel Switching the activity of Cas12a using guide RNA strand displacement circuits
description	Cas12a is a useful alternative to Cas9 for genome editing and regulation. Here the authors design strand displacement gRNAs that can add functionality to Cas12a by acting as multi-input logic gates.
format	article
author	Lukas Oesinghaus Friedrich C. Simmel
author_facet	Lukas Oesinghaus Friedrich C. Simmel
author_sort	Lukas Oesinghaus
title	Switching the activity of Cas12a using guide RNA strand displacement circuits
title_short	Switching the activity of Cas12a using guide RNA strand displacement circuits
title_full	Switching the activity of Cas12a using guide RNA strand displacement circuits
title_fullStr	Switching the activity of Cas12a using guide RNA strand displacement circuits
title_full_unstemmed	Switching the activity of Cas12a using guide RNA strand displacement circuits
title_sort	switching the activity of cas12a using guide rna strand displacement circuits
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/79110551716e4defa6c6b1044bdfa7e0
work_keys_str_mv	AT lukasoesinghaus switchingtheactivityofcas12ausingguidernastranddisplacementcircuits AT friedrichcsimmel switchingtheactivityofcas12ausingguidernastranddisplacementcircuits
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Switching the activity of Cas12a using guide RNA strand displacement circuits

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