Altered Brain Structure and Spontaneous Functional Activity in Children With Concomitant Strabismus

Strabismus occurs in about 2% of children and may result in amblyopia or lazy eyes and loss of depth perception. However, whether/how long-term strabismus shapes the brain structure and functions in children with concomitant strabismus (CS) is still unclear. In this study, a total of 26 patients wit...

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Autores principales:	Xiaohui Yin, Lingjun Chen, Mingyue Ma, Hong Zhang, Ming Gao, Xiaoping Wu, Yongqiang Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	concomitant strabismus cortical thickness ALFF structural MRI resting-state fMRI Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/7912460dbcb248d495c1bd2e0dda1c6e
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spelling	oai:doaj.org-article:7912460dbcb248d495c1bd2e0dda1c6e2021-11-15T04:50:51ZAltered Brain Structure and Spontaneous Functional Activity in Children With Concomitant Strabismus1662-516110.3389/fnhum.2021.777762https://doaj.org/article/7912460dbcb248d495c1bd2e0dda1c6e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnhum.2021.777762/fullhttps://doaj.org/toc/1662-5161Strabismus occurs in about 2% of children and may result in amblyopia or lazy eyes and loss of depth perception. However, whether/how long-term strabismus shapes the brain structure and functions in children with concomitant strabismus (CS) is still unclear. In this study, a total of 26 patients with CS and 28 age-, sex-, and education-matched healthy controls (HCs) underwent structural and resting-state functional magnetic resonance imaging examination. The cortical thickness and amplitude of low-frequency fluctuation (ALFF) were calculated to assess the structural and functional plasticity in children with CS. Compared with HCs group, patients with CS showed increased cortical thickness in the precentral gyrus and angular gyrus while decreased cortical thickness in the left intraparietal sulcus, parieto-occipital sulcus, superior and middle temporal gyrus, right ventral premotor cortex, anterior insula, orbitofrontal cortex, and paracentral lobule. Meanwhile, CS patients exhibited increased ALFF in the prefrontal cortex and superior temporal gyrus, and decreased ALFF in the caudate and hippocampus. These results show that children with CS have abnormal structure and function in brain regions subserving eye movement, controls, and high-order cognitive functions. Our findings revealed the structural and functional abnormalities induced by CS and may provide new insight into the underlying neural mechanisms for CS.Xiaohui YinLingjun ChenMingyue MaHong ZhangMing GaoXiaoping WuYongqiang LiFrontiers Media S.A.articleconcomitant strabismuscortical thicknessALFFstructural MRIresting-state fMRINeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Human Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	concomitant strabismus cortical thickness ALFF structural MRI resting-state fMRI Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	concomitant strabismus cortical thickness ALFF structural MRI resting-state fMRI Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Xiaohui Yin Lingjun Chen Mingyue Ma Hong Zhang Ming Gao Xiaoping Wu Yongqiang Li Altered Brain Structure and Spontaneous Functional Activity in Children With Concomitant Strabismus
description	Strabismus occurs in about 2% of children and may result in amblyopia or lazy eyes and loss of depth perception. However, whether/how long-term strabismus shapes the brain structure and functions in children with concomitant strabismus (CS) is still unclear. In this study, a total of 26 patients with CS and 28 age-, sex-, and education-matched healthy controls (HCs) underwent structural and resting-state functional magnetic resonance imaging examination. The cortical thickness and amplitude of low-frequency fluctuation (ALFF) were calculated to assess the structural and functional plasticity in children with CS. Compared with HCs group, patients with CS showed increased cortical thickness in the precentral gyrus and angular gyrus while decreased cortical thickness in the left intraparietal sulcus, parieto-occipital sulcus, superior and middle temporal gyrus, right ventral premotor cortex, anterior insula, orbitofrontal cortex, and paracentral lobule. Meanwhile, CS patients exhibited increased ALFF in the prefrontal cortex and superior temporal gyrus, and decreased ALFF in the caudate and hippocampus. These results show that children with CS have abnormal structure and function in brain regions subserving eye movement, controls, and high-order cognitive functions. Our findings revealed the structural and functional abnormalities induced by CS and may provide new insight into the underlying neural mechanisms for CS.
format	article
author	Xiaohui Yin Lingjun Chen Mingyue Ma Hong Zhang Ming Gao Xiaoping Wu Yongqiang Li
author_facet	Xiaohui Yin Lingjun Chen Mingyue Ma Hong Zhang Ming Gao Xiaoping Wu Yongqiang Li
author_sort	Xiaohui Yin
title	Altered Brain Structure and Spontaneous Functional Activity in Children With Concomitant Strabismus
title_short	Altered Brain Structure and Spontaneous Functional Activity in Children With Concomitant Strabismus
title_full	Altered Brain Structure and Spontaneous Functional Activity in Children With Concomitant Strabismus
title_fullStr	Altered Brain Structure and Spontaneous Functional Activity in Children With Concomitant Strabismus
title_full_unstemmed	Altered Brain Structure and Spontaneous Functional Activity in Children With Concomitant Strabismus
title_sort	altered brain structure and spontaneous functional activity in children with concomitant strabismus
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7912460dbcb248d495c1bd2e0dda1c6e
work_keys_str_mv	AT xiaohuiyin alteredbrainstructureandspontaneousfunctionalactivityinchildrenwithconcomitantstrabismus AT lingjunchen alteredbrainstructureandspontaneousfunctionalactivityinchildrenwithconcomitantstrabismus AT mingyuema alteredbrainstructureandspontaneousfunctionalactivityinchildrenwithconcomitantstrabismus AT hongzhang alteredbrainstructureandspontaneousfunctionalactivityinchildrenwithconcomitantstrabismus AT minggao alteredbrainstructureandspontaneousfunctionalactivityinchildrenwithconcomitantstrabismus AT xiaopingwu alteredbrainstructureandspontaneousfunctionalactivityinchildrenwithconcomitantstrabismus AT yongqiangli alteredbrainstructureandspontaneousfunctionalactivityinchildrenwithconcomitantstrabismus
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Altered Brain Structure and Spontaneous Functional Activity in Children With Concomitant Strabismus

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