Estrogen receptor (ER) and progesterone receptor (PgR) in breast cancer of Indian women

Amit V Patil1, Rahul S Bhamre2, Rajeev Singhai3, Mukund B Tayade4, Vinayak W Patil31Department of General Surgery, Government Medical College, Miraj, Maharashtra, India; 2Department of General Surgery, DY Patil Hospital and Research Centre, Nerul, Navi Mumbai, India; 3Department of Biochemistry, Gra...

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Autores principales:	Patil AV, Bhamre RS, Singhai R, Tayade MB, Patil VW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/791322e89e2d4a25bc11dacd417c776e
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spelling	oai:doaj.org-article:791322e89e2d4a25bc11dacd417c776e2021-12-02T02:26:27ZEstrogen receptor (ER) and progesterone receptor (PgR) in breast cancer of Indian women1179-1314https://doaj.org/article/791322e89e2d4a25bc11dacd417c776e2011-04-01T00:00:00Zhttp://www.dovepress.com/estrogen-receptor-er-and-progesterone-receptor-pgr-in-breast-cancer-of-a7149https://doaj.org/toc/1179-1314Amit V Patil1, Rahul S Bhamre2, Rajeev Singhai3, Mukund B Tayade4, Vinayak W Patil31Department of General Surgery, Government Medical College, Miraj, Maharashtra, India; 2Department of General Surgery, DY Patil Hospital and Research Centre, Nerul, Navi Mumbai, India; 3Department of Biochemistry, Grant Medical College and Sir JJ Group of Hospitals Mumbai, India; 4Department of General Surgery, Grant Medical College and Sir JJ Group of Hospitals Mumbai, IndiaObjective: To determine the expressions and relationship between estrogen receptors (ERs) and progesterone receptors (PgRs) in breast cancer in Indian women.Participants: Surgically removed breast cancer tissues were collected from Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India, taking (n = 300) cases of infiltrating duct cancer of Indian women after radical mastectomy and lumpectomy; the age- and menopausal-related subgroups satisfied this requirement.Measurements: Statistical significance was calculated by the likelihood ratio test; relative risk served to check for significant differences. Relapse-free interval probabilities were calculated according to Kaplan and Meier, with Cox&ndash;Mantel test comparing survival functions and P values.Results: We observed that only in middle-aged postmenopausal patients bearing pT2 tumors were ER and PgR receptors shown to have a prognostic significance with the lowest tested cutoff value being 5 fmol/mg.Conclusion: Immunohistochemistry analysis has been shown to be a prognostic factor for patients with breast cancer; the major aim of determining the ER receptor status is to assess predictive response to hormonal therapy.Keywords: prognostic cancer tissue biomarkers, immunohistochemistry, hormone receptors, steroid receptors Patil AVBhamre RSSinghai RTayade MBPatil VWDove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2011, Iss default, Pp 27-33 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Patil AV Bhamre RS Singhai R Tayade MB Patil VW Estrogen receptor (ER) and progesterone receptor (PgR) in breast cancer of Indian women
description	Amit V Patil1, Rahul S Bhamre2, Rajeev Singhai3, Mukund B Tayade4, Vinayak W Patil31Department of General Surgery, Government Medical College, Miraj, Maharashtra, India; 2Department of General Surgery, DY Patil Hospital and Research Centre, Nerul, Navi Mumbai, India; 3Department of Biochemistry, Grant Medical College and Sir JJ Group of Hospitals Mumbai, India; 4Department of General Surgery, Grant Medical College and Sir JJ Group of Hospitals Mumbai, IndiaObjective: To determine the expressions and relationship between estrogen receptors (ERs) and progesterone receptors (PgRs) in breast cancer in Indian women.Participants: Surgically removed breast cancer tissues were collected from Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India, taking (n = 300) cases of infiltrating duct cancer of Indian women after radical mastectomy and lumpectomy; the age- and menopausal-related subgroups satisfied this requirement.Measurements: Statistical significance was calculated by the likelihood ratio test; relative risk served to check for significant differences. Relapse-free interval probabilities were calculated according to Kaplan and Meier, with Cox&ndash;Mantel test comparing survival functions and P values.Results: We observed that only in middle-aged postmenopausal patients bearing pT2 tumors were ER and PgR receptors shown to have a prognostic significance with the lowest tested cutoff value being 5 fmol/mg.Conclusion: Immunohistochemistry analysis has been shown to be a prognostic factor for patients with breast cancer; the major aim of determining the ER receptor status is to assess predictive response to hormonal therapy.Keywords: prognostic cancer tissue biomarkers, immunohistochemistry, hormone receptors, steroid receptors
format	article
author	Patil AV Bhamre RS Singhai R Tayade MB Patil VW
author_facet	Patil AV Bhamre RS Singhai R Tayade MB Patil VW
author_sort	Patil AV
title	Estrogen receptor (ER) and progesterone receptor (PgR) in breast cancer of Indian women
title_short	Estrogen receptor (ER) and progesterone receptor (PgR) in breast cancer of Indian women
title_full	Estrogen receptor (ER) and progesterone receptor (PgR) in breast cancer of Indian women
title_fullStr	Estrogen receptor (ER) and progesterone receptor (PgR) in breast cancer of Indian women
title_full_unstemmed	Estrogen receptor (ER) and progesterone receptor (PgR) in breast cancer of Indian women
title_sort	estrogen receptor (er) and progesterone receptor (pgr) in breast cancer of indian women
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/791322e89e2d4a25bc11dacd417c776e
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Estrogen receptor (ER) and progesterone receptor (PgR) in breast cancer of Indian women

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