Carotid artery calcification score and its association with cognitive impairment

Zhou Chu, Liu Cheng, Qiao Tong Department of Vascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China Purpose: To retrospectively investigate the possible association between carotid artery calcification score (CS) and cognitive impa...

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Autores principales:	Chu Z, Cheng L, Tong Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	calcification score carotid artery stenosis cognitive impairment plaque burden Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7914fda8e8634e3f8e499e22157907eb
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spelling	oai:doaj.org-article:7914fda8e8634e3f8e499e22157907eb2021-12-02T00:26:55ZCarotid artery calcification score and its association with cognitive impairment1178-1998https://doaj.org/article/7914fda8e8634e3f8e499e22157907eb2019-01-01T00:00:00Zhttps://www.dovepress.com/carotid-artery-calcification-score-and-its-association-with-cognitive--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Zhou Chu, Liu Cheng, Qiao Tong Department of Vascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China Purpose: To retrospectively investigate the possible association between carotid artery calcification score (CS) and cognitive impairment in carotid artery stenosis (CAS) patients.Patients and methods: Carotid artery was measured in 102 patients with cervical carotid arteries using Color Doppler ultrasound, multi-detector row spiral CT angiography and MRI scanning. Correlation analysis between CSs obtained by MD CT and cognitive scores was performed, and the correlation between CSs and vascular stenosis degree and MRI-measured plaque histological (lipid-rich necrotic nucleus [LRNC], intraplaque hemorrhage and fibrous cap surface rupture) and morphological parameters (lumen area [LA], wall area [WA], total area of blood vessels [TVA], plaque burden [PB]) was analyzed. Follow-up review analysis was conducted on 38 postoperative patients.Results: Significant negative correlation was discovered between CS value and cognitive scores in CAS patients (R=-0.359, P<0.001), which did not exist in postoperative patients (P=0.348); CS value also showed significant correlation with WA (R=0.521, P=0.042), TVA (R=0.215, P=0.017) and PB (R=0.237, P=0.003) and had a certain predictive value for the occurrence probability of carotid plaque LRNC (P=0.029, AUC =0.780) in preoperative patients.Conclusion: Carotid artery CSs have significant correlation with cognitive scores, which could be used as risk factor for early screening of cognitive impairment in CAS patients. The possible mechanism may be related to the calcification impact on the plaque burden. Keywords: calcification score, carotid artery stenosis, cognitive impairment, plaque burdenChu ZCheng LTong QDove Medical Pressarticlecalcification scorecarotid artery stenosiscognitive impairmentplaque burdenGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 167-177 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	calcification score carotid artery stenosis cognitive impairment plaque burden Geriatrics RC952-954.6
spellingShingle	calcification score carotid artery stenosis cognitive impairment plaque burden Geriatrics RC952-954.6 Chu Z Cheng L Tong Q Carotid artery calcification score and its association with cognitive impairment
description	Zhou Chu, Liu Cheng, Qiao Tong Department of Vascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China Purpose: To retrospectively investigate the possible association between carotid artery calcification score (CS) and cognitive impairment in carotid artery stenosis (CAS) patients.Patients and methods: Carotid artery was measured in 102 patients with cervical carotid arteries using Color Doppler ultrasound, multi-detector row spiral CT angiography and MRI scanning. Correlation analysis between CSs obtained by MD CT and cognitive scores was performed, and the correlation between CSs and vascular stenosis degree and MRI-measured plaque histological (lipid-rich necrotic nucleus [LRNC], intraplaque hemorrhage and fibrous cap surface rupture) and morphological parameters (lumen area [LA], wall area [WA], total area of blood vessels [TVA], plaque burden [PB]) was analyzed. Follow-up review analysis was conducted on 38 postoperative patients.Results: Significant negative correlation was discovered between CS value and cognitive scores in CAS patients (R=-0.359, P<0.001), which did not exist in postoperative patients (P=0.348); CS value also showed significant correlation with WA (R=0.521, P=0.042), TVA (R=0.215, P=0.017) and PB (R=0.237, P=0.003) and had a certain predictive value for the occurrence probability of carotid plaque LRNC (P=0.029, AUC =0.780) in preoperative patients.Conclusion: Carotid artery CSs have significant correlation with cognitive scores, which could be used as risk factor for early screening of cognitive impairment in CAS patients. The possible mechanism may be related to the calcification impact on the plaque burden. Keywords: calcification score, carotid artery stenosis, cognitive impairment, plaque burden
format	article
author	Chu Z Cheng L Tong Q
author_facet	Chu Z Cheng L Tong Q
author_sort	Chu Z
title	Carotid artery calcification score and its association with cognitive impairment
title_short	Carotid artery calcification score and its association with cognitive impairment
title_full	Carotid artery calcification score and its association with cognitive impairment
title_fullStr	Carotid artery calcification score and its association with cognitive impairment
title_full_unstemmed	Carotid artery calcification score and its association with cognitive impairment
title_sort	carotid artery calcification score and its association with cognitive impairment
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/7914fda8e8634e3f8e499e22157907eb
work_keys_str_mv	AT chuz carotidarterycalcificationscoreanditsassociationwithcognitiveimpairment AT chengl carotidarterycalcificationscoreanditsassociationwithcognitiveimpairment AT tongq carotidarterycalcificationscoreanditsassociationwithcognitiveimpairment
_version_	1718403745772994560

Carotid artery calcification score and its association with cognitive impairment

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