Profile of acute infectious markers in sporadic hepatitis E.
Laboratory diagnosis of acute infection of hepatitis E virus (HEV) is commonly based on the detection of HEV RNA, IgM and/or rising IgG levels. However, the profile of these markers when the patients present have not been well determined. To clarify the extent of misdiagnosed sporadic hepatitis E in...
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2010
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oai:doaj.org-article:7917820667a24f4b89681d11d53db5f22021-11-18T07:03:01ZProfile of acute infectious markers in sporadic hepatitis E.1932-620310.1371/journal.pone.0013560https://doaj.org/article/7917820667a24f4b89681d11d53db5f22010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21042408/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Laboratory diagnosis of acute infection of hepatitis E virus (HEV) is commonly based on the detection of HEV RNA, IgM and/or rising IgG levels. However, the profile of these markers when the patients present have not been well determined. To clarify the extent of misdiagnosed sporadic hepatitis E in the initial laboratory detection, serial sera of 271 sporadic acute hepatitis cases were collected, detected and the dynamics of each acute marker during the illness course were analyzed. 91 confirmed cases of hepatitis E were identified based on the presentation of HEV RNA, IgM or at least 4 fold rising of IgG levels. 21 (23.1%) hepatitis E cases were false negative for the viral RNA and 40 (44.0%) for rising IgG, because occurrence of these markers were confined to acute phase of infection and viremia had already subsided and antibody level peaked when these patients presented. IgM was detected in 82 (90.1%) cases. It is the most prevalent of the three markers, because the antibody persisted until early convalescence. Nine cases negative for IgM were positive for rising IgG and one was also positive for the viral RNA; all of these nine cases showed high avid IgG in their acute phase sera, which indicated re-infection. In summary, it is not practicable to determine the true occurrence of sporadic hepatitis E. Nevertheless, it could be closely approximated by approach using a combination of all three acute markers.Shoujie HuangXuefeng ZhangHanmin JiangQiang YanXing AiYijun WangJiaping CaiLang JiangTing WuZhongze WangLi GuanJ Wai Kuo ShihMun-Hon NgFengcai ZhuJun ZhangNingshao XiaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 10, p e13560 (2010) |
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Medicine R Science Q |
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Medicine R Science Q Shoujie Huang Xuefeng Zhang Hanmin Jiang Qiang Yan Xing Ai Yijun Wang Jiaping Cai Lang Jiang Ting Wu Zhongze Wang Li Guan J Wai Kuo Shih Mun-Hon Ng Fengcai Zhu Jun Zhang Ningshao Xia Profile of acute infectious markers in sporadic hepatitis E. |
| description |
Laboratory diagnosis of acute infection of hepatitis E virus (HEV) is commonly based on the detection of HEV RNA, IgM and/or rising IgG levels. However, the profile of these markers when the patients present have not been well determined. To clarify the extent of misdiagnosed sporadic hepatitis E in the initial laboratory detection, serial sera of 271 sporadic acute hepatitis cases were collected, detected and the dynamics of each acute marker during the illness course were analyzed. 91 confirmed cases of hepatitis E were identified based on the presentation of HEV RNA, IgM or at least 4 fold rising of IgG levels. 21 (23.1%) hepatitis E cases were false negative for the viral RNA and 40 (44.0%) for rising IgG, because occurrence of these markers were confined to acute phase of infection and viremia had already subsided and antibody level peaked when these patients presented. IgM was detected in 82 (90.1%) cases. It is the most prevalent of the three markers, because the antibody persisted until early convalescence. Nine cases negative for IgM were positive for rising IgG and one was also positive for the viral RNA; all of these nine cases showed high avid IgG in their acute phase sera, which indicated re-infection. In summary, it is not practicable to determine the true occurrence of sporadic hepatitis E. Nevertheless, it could be closely approximated by approach using a combination of all three acute markers. |
| format |
article |
| author |
Shoujie Huang Xuefeng Zhang Hanmin Jiang Qiang Yan Xing Ai Yijun Wang Jiaping Cai Lang Jiang Ting Wu Zhongze Wang Li Guan J Wai Kuo Shih Mun-Hon Ng Fengcai Zhu Jun Zhang Ningshao Xia |
| author_facet |
Shoujie Huang Xuefeng Zhang Hanmin Jiang Qiang Yan Xing Ai Yijun Wang Jiaping Cai Lang Jiang Ting Wu Zhongze Wang Li Guan J Wai Kuo Shih Mun-Hon Ng Fengcai Zhu Jun Zhang Ningshao Xia |
| author_sort |
Shoujie Huang |
| title |
Profile of acute infectious markers in sporadic hepatitis E. |
| title_short |
Profile of acute infectious markers in sporadic hepatitis E. |
| title_full |
Profile of acute infectious markers in sporadic hepatitis E. |
| title_fullStr |
Profile of acute infectious markers in sporadic hepatitis E. |
| title_full_unstemmed |
Profile of acute infectious markers in sporadic hepatitis E. |
| title_sort |
profile of acute infectious markers in sporadic hepatitis e. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2010 |
| url |
https://doaj.org/article/7917820667a24f4b89681d11d53db5f2 |
| work_keys_str_mv |
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