The correlation between longitudinal changes in hypothalamic–pituitary–adrenal (HPA)-axis activity and changes in neurocognitive function in mixed-state bipolar II disorder

The correlation between longitudinal changes in hypothalamic–pituitary–adrenal (HPA)-axis activity and changes in neurocognitive function in mixed-state bipolar II disorder

Hsuan-Han Lee,1 Cheng-Ho Chang,1 Liang-Jen Wang,2 Chih-Ching Wu,3,4 Hsing-Ling Chen,5 Ti Lu,1 Ru-Band Lu6,7 Sheng-Yu Lee1,6,8,9 1Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 2Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital a...

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Autores principales: Lee HH, Chang CH, Wang LJ, Wu CC, Chen HL, Lu T, Lu RB, Lee SY
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
Bipolar II disorder
cognitive function
cortisol level
correlation.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/79195cc05c6c4c82997ee4f5d3167134
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spelling oai:doaj.org-article:79195cc05c6c4c82997ee4f5d31671342021-12-02T00:35:12ZThe correlation between longitudinal changes in hypothalamic–pituitary–adrenal (HPA)-axis activity and changes in neurocognitive function in mixed-state bipolar II disorder1178-2021https://doaj.org/article/79195cc05c6c4c82997ee4f5d31671342018-10-01T00:00:00Zhttps://www.dovepress.com/the-correlation-between-longitudinal-changes-in-hypothalamic-pituitary-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Hsuan-Han Lee,1 Cheng-Ho Chang,1 Liang-Jen Wang,2 Chih-Ching Wu,3,4 Hsing-Ling Chen,5 Ti Lu,1 Ru-Band Lu6,7 Sheng-Yu Lee1,6,8,9 1Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 2Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; 3Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 4Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan; 5Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 6Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan; 7Institute of Behavioral Medicine Sciences, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan; 8Department of Psychiatry, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 9Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan Introduction: In this study, we aim to determine 1) the differences in cortisol in patients with bipolar II disorder (BD-II) and control subjects and 2) the correlation between cortisol levels and cognitive function in patients with BD-II during a 24-week follow-up period.Methods: We recruited a total of 32 BD-II patients and 30 healthy control subjects. The BD-II patients were assessed for clinical severity and serum cortisol level at baseline and at weeks 8, 16, and 24. The Brief Assessment of Cognition in Affective Disorders (BACA) was adopted to evaluate cognitive function at baseline and endpoint (week 24). Meanwhile, we assessed the controls for serum cortisol level and BACA at baseline.Results: We observed that the BD-II group had a higher serum cortisol level and lower BACA composite scores compared with the healthy controls at baseline. A significant correlation was found between changes in Verbal Fluency, a subset of BACA, and changes in serum cortisol level after the 24-week follow-up, controlling for age, gender, years of education, and clinical severity (P<0.001).Conclusion: We propose that serum cortisol may be involved in the psychopathological mechanisms of cognitive decline in BD-II. Keywords: bipolar II disorder, cognitive function, cortisol level, correlationLee HHChang CHWang LJWu CCChen HLLu TLu RBLee SYDove Medical PressarticleBipolar II disordercognitive functioncortisol levelcorrelation.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2703-2713 (2018)
institution DOAJ
collection DOAJ
language EN
topic Bipolar II disorder
cognitive function
cortisol level
correlation.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Bipolar II disorder
cognitive function
cortisol level
correlation.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Lee HH
Chang CH
Wang LJ
Wu CC
Chen HL
Lu T
Lu RB
Lee SY
The correlation between longitudinal changes in hypothalamic–pituitary–adrenal (HPA)-axis activity and changes in neurocognitive function in mixed-state bipolar II disorder
description Hsuan-Han Lee,1 Cheng-Ho Chang,1 Liang-Jen Wang,2 Chih-Ching Wu,3,4 Hsing-Ling Chen,5 Ti Lu,1 Ru-Band Lu6,7 Sheng-Yu Lee1,6,8,9 1Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 2Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; 3Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 4Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan; 5Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 6Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan; 7Institute of Behavioral Medicine Sciences, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan; 8Department of Psychiatry, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 9Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan Introduction: In this study, we aim to determine 1) the differences in cortisol in patients with bipolar II disorder (BD-II) and control subjects and 2) the correlation between cortisol levels and cognitive function in patients with BD-II during a 24-week follow-up period.Methods: We recruited a total of 32 BD-II patients and 30 healthy control subjects. The BD-II patients were assessed for clinical severity and serum cortisol level at baseline and at weeks 8, 16, and 24. The Brief Assessment of Cognition in Affective Disorders (BACA) was adopted to evaluate cognitive function at baseline and endpoint (week 24). Meanwhile, we assessed the controls for serum cortisol level and BACA at baseline.Results: We observed that the BD-II group had a higher serum cortisol level and lower BACA composite scores compared with the healthy controls at baseline. A significant correlation was found between changes in Verbal Fluency, a subset of BACA, and changes in serum cortisol level after the 24-week follow-up, controlling for age, gender, years of education, and clinical severity (P<0.001).Conclusion: We propose that serum cortisol may be involved in the psychopathological mechanisms of cognitive decline in BD-II. Keywords: bipolar II disorder, cognitive function, cortisol level, correlation
format article
author Lee HH
Chang CH
Wang LJ
Wu CC
Chen HL
Lu T
Lu RB
Lee SY
author_facet Lee HH
Chang CH
Wang LJ
Wu CC
Chen HL
Lu T
Lu RB
Lee SY
author_sort Lee HH
title The correlation between longitudinal changes in hypothalamic–pituitary–adrenal (HPA)-axis activity and changes in neurocognitive function in mixed-state bipolar II disorder
title_short The correlation between longitudinal changes in hypothalamic–pituitary–adrenal (HPA)-axis activity and changes in neurocognitive function in mixed-state bipolar II disorder
title_full The correlation between longitudinal changes in hypothalamic–pituitary–adrenal (HPA)-axis activity and changes in neurocognitive function in mixed-state bipolar II disorder
title_fullStr The correlation between longitudinal changes in hypothalamic–pituitary–adrenal (HPA)-axis activity and changes in neurocognitive function in mixed-state bipolar II disorder
title_full_unstemmed The correlation between longitudinal changes in hypothalamic–pituitary–adrenal (HPA)-axis activity and changes in neurocognitive function in mixed-state bipolar II disorder
title_sort correlation between longitudinal changes in hypothalamic–pituitary–adrenal (hpa)-axis activity and changes in neurocognitive function in mixed-state bipolar ii disorder
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/79195cc05c6c4c82997ee4f5d3167134
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