HLA diversity in the Argentinian Umbilical Cord Blood Bank: frequencies according to donor’s reported ancestry and geographical distribution

Abstract Umbilical cord blood (UCB) is a suitable source for hematopoietic stem cell transplantation. The study of HLA genes by next generation sequencing is commonly used in transplants. Donor/patient HLA matching is often higher within groups of common ancestry, however “Hispanic” is a broad categ...

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Autores principales:	Daniela Fernández Souto, Julieta Rosello, Laura Lazo, Florencia Veloso, Cecilia Gamba, Silvina Kuperman, Valeria Roca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7919d2832fef4d11ba52d0a38f6b1158
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spelling	oai:doaj.org-article:7919d2832fef4d11ba52d0a38f6b11582021-12-02T14:04:00ZHLA diversity in the Argentinian Umbilical Cord Blood Bank: frequencies according to donor’s reported ancestry and geographical distribution10.1038/s41598-021-83282-12045-2322https://doaj.org/article/7919d2832fef4d11ba52d0a38f6b11582021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83282-1https://doaj.org/toc/2045-2322Abstract Umbilical cord blood (UCB) is a suitable source for hematopoietic stem cell transplantation. The study of HLA genes by next generation sequencing is commonly used in transplants. Donor/patient HLA matching is often higher within groups of common ancestry, however “Hispanic” is a broad category that fails to represent Argentina’s complex genetic admixture. Our aim is to describe HLA diversity of banked UCB units collected across the country taking into consideration donor’s reported ancestral origins as well as geographic distribution. Our results showed an evenly distribution of units mainly for 2 groups: of European and of Native American descent, each associated to a defined geographic location pattern (Central vs. North regions). We observed differences in allele frequency distributions for some alleles previously described in Amerindian populations: for Class I (A68:17, A02:11:01G, A02:22:01G, B39:05:01, B35:21, B40:04, B15:04:01G, B35:04:01, B51:13:01) and Class II (DRB104:11:01, DRB104:07:01G/03, DRB108:02:01, DRB108:07, DRB109:01:02G, DRB114:02:01, DRB116:02:01G). Our database expands the current knowledge of HLA diversity in Argentinian population. Although further studies are necessary to fully comprehend HLA heterogeneity, this report should prove useful to increase the possibility of finding compatible donors for successful allogeneic transplant and to improve recruitment strategies for UCB donors across the country.Daniela Fernández SoutoJulieta RoselloLaura LazoFlorencia VelosoCecilia GambaSilvina KupermanValeria RocaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniela Fernández Souto Julieta Rosello Laura Lazo Florencia Veloso Cecilia Gamba Silvina Kuperman Valeria Roca HLA diversity in the Argentinian Umbilical Cord Blood Bank: frequencies according to donor’s reported ancestry and geographical distribution
description	Abstract Umbilical cord blood (UCB) is a suitable source for hematopoietic stem cell transplantation. The study of HLA genes by next generation sequencing is commonly used in transplants. Donor/patient HLA matching is often higher within groups of common ancestry, however “Hispanic” is a broad category that fails to represent Argentina’s complex genetic admixture. Our aim is to describe HLA diversity of banked UCB units collected across the country taking into consideration donor’s reported ancestral origins as well as geographic distribution. Our results showed an evenly distribution of units mainly for 2 groups: of European and of Native American descent, each associated to a defined geographic location pattern (Central vs. North regions). We observed differences in allele frequency distributions for some alleles previously described in Amerindian populations: for Class I (A68:17, A02:11:01G, A02:22:01G, B39:05:01, B35:21, B40:04, B15:04:01G, B35:04:01, B51:13:01) and Class II (DRB104:11:01, DRB104:07:01G/03, DRB108:02:01, DRB108:07, DRB109:01:02G, DRB114:02:01, DRB116:02:01G). Our database expands the current knowledge of HLA diversity in Argentinian population. Although further studies are necessary to fully comprehend HLA heterogeneity, this report should prove useful to increase the possibility of finding compatible donors for successful allogeneic transplant and to improve recruitment strategies for UCB donors across the country.
format	article
author	Daniela Fernández Souto Julieta Rosello Laura Lazo Florencia Veloso Cecilia Gamba Silvina Kuperman Valeria Roca
author_facet	Daniela Fernández Souto Julieta Rosello Laura Lazo Florencia Veloso Cecilia Gamba Silvina Kuperman Valeria Roca
author_sort	Daniela Fernández Souto
title	HLA diversity in the Argentinian Umbilical Cord Blood Bank: frequencies according to donor’s reported ancestry and geographical distribution
title_short	HLA diversity in the Argentinian Umbilical Cord Blood Bank: frequencies according to donor’s reported ancestry and geographical distribution
title_full	HLA diversity in the Argentinian Umbilical Cord Blood Bank: frequencies according to donor’s reported ancestry and geographical distribution
title_fullStr	HLA diversity in the Argentinian Umbilical Cord Blood Bank: frequencies according to donor’s reported ancestry and geographical distribution
title_full_unstemmed	HLA diversity in the Argentinian Umbilical Cord Blood Bank: frequencies according to donor’s reported ancestry and geographical distribution
title_sort	hla diversity in the argentinian umbilical cord blood bank: frequencies according to donor’s reported ancestry and geographical distribution
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7919d2832fef4d11ba52d0a38f6b1158
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HLA diversity in the Argentinian Umbilical Cord Blood Bank: frequencies according to donor’s reported ancestry and geographical distribution

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