PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER

In spite of extreme controversies on possible role of cytokines as regulating factors in cancer pathology, their role during carcinogenesis is beyond doubts. Since regulation of cytokine gene expression is known to proceed, mainly, at the level of transcription, from promoter region, we have underta...

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Autores principales:	A. V. Shevchenko, O. V. Golovanova, M. Ju. Kolomejtchuk, V. I. Konenkov, E. Ju. Garbukov, M. N. Stakheeva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	breast cancer polymorphism il-4 il-6 il-10 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/791e00c302b14dcd872f74401f884c07
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spelling	oai:doaj.org-article:791e00c302b14dcd872f74401f884c072021-11-18T08:03:37ZPROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER1563-06252313-741X10.15789/1563-0625-2009-1-21-28https://doaj.org/article/791e00c302b14dcd872f74401f884c072014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/37https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIn spite of extreme controversies on possible role of cytokines as regulating factors in cancer pathology, their role during carcinogenesis is beyond doubts. Since regulation of cytokine gene expression is known to proceed, mainly, at the level of transcription, from promoter region, we have undertaken an analysis of genotypic frequencies in promoter regions of IL-4, IL-6 and IL-10 genes for a group of relatively healthy women and patients with breast cancer. Some specific features of allelic distribution have been found in groups of healthy women, among cohorts with hereditary predisposition, including the patients with breast cancer who had clustering of the disease in families (i.e., mother, grandmother, or sister been affected).A. V. ShevchenkoO. V. GolovanovaM. Ju. KolomejtchukV. I. KonenkovE. Ju. GarbukovM. N. StakheevaSPb RAACIarticlebreast cancerpolymorphismil-4il-6il-10Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 1, Pp 21-28 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	breast cancer polymorphism il-4 il-6 il-10 Immunologic diseases. Allergy RC581-607
spellingShingle	breast cancer polymorphism il-4 il-6 il-10 Immunologic diseases. Allergy RC581-607 A. V. Shevchenko O. V. Golovanova M. Ju. Kolomejtchuk V. I. Konenkov E. Ju. Garbukov M. N. Stakheeva PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER
description	In spite of extreme controversies on possible role of cytokines as regulating factors in cancer pathology, their role during carcinogenesis is beyond doubts. Since regulation of cytokine gene expression is known to proceed, mainly, at the level of transcription, from promoter region, we have undertaken an analysis of genotypic frequencies in promoter regions of IL-4, IL-6 and IL-10 genes for a group of relatively healthy women and patients with breast cancer. Some specific features of allelic distribution have been found in groups of healthy women, among cohorts with hereditary predisposition, including the patients with breast cancer who had clustering of the disease in families (i.e., mother, grandmother, or sister been affected).
format	article
author	A. V. Shevchenko O. V. Golovanova M. Ju. Kolomejtchuk V. I. Konenkov E. Ju. Garbukov M. N. Stakheeva
author_facet	A. V. Shevchenko O. V. Golovanova M. Ju. Kolomejtchuk V. I. Konenkov E. Ju. Garbukov M. N. Stakheeva
author_sort	A. V. Shevchenko
title	PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER
title_short	PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER
title_full	PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER
title_fullStr	PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER
title_full_unstemmed	PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER
title_sort	promotor polymorphism of il-4, il-6, and il-10 genes among patients with breast cancer
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/791e00c302b14dcd872f74401f884c07
work_keys_str_mv	AT avshevchenko promotorpolymorphismofil4il6andil10genesamongpatientswithbreastcancer AT ovgolovanova promotorpolymorphismofil4il6andil10genesamongpatientswithbreastcancer AT mjukolomejtchuk promotorpolymorphismofil4il6andil10genesamongpatientswithbreastcancer AT vikonenkov promotorpolymorphismofil4il6andil10genesamongpatientswithbreastcancer AT ejugarbukov promotorpolymorphismofil4il6andil10genesamongpatientswithbreastcancer AT mnstakheeva promotorpolymorphismofil4il6andil10genesamongpatientswithbreastcancer
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PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER

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