Airspace Dimension Assessment with nanoparticles reflects lung density as quantified by MRI

H Laura Aaltonen,1,2,* Simon S Kindvall,3,* Jonas K Jakobsson,4 Jakob Löndahl,4 Lars E Olsson,3,5 Sandra Diaz,1,2 Sophia Zackrisson,1,2 Per Wollmer1,2 1Department of Medical Imaging and Physiology, Skåne University Hospital, Malmö, Sweden; 2Department of Translational Me...

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Autores principales:	Aaltonen HL, Kindvall SS, Jakobsson JK, Löndahl J, Olsson LE, Diaz S, Zackrisson S, Wollmer P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	nanoparticles respiratory diagnostics distal airspaces AiDA airspace dimension assessment MR densitometry Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/79208b4ebe294ce1b74aebe22d78dd73
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spelling	oai:doaj.org-article:79208b4ebe294ce1b74aebe22d78dd732021-12-02T02:51:03ZAirspace Dimension Assessment with nanoparticles reflects lung density as quantified by MRI1178-2013https://doaj.org/article/79208b4ebe294ce1b74aebe22d78dd732018-05-01T00:00:00Zhttps://www.dovepress.com/airspace-dimension-assessment-with-nanoparticles-reflects-lung-density-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013H Laura Aaltonen,1,2,* Simon S Kindvall,3,* Jonas K Jakobsson,4 Jakob Löndahl,4 Lars E Olsson,3,5 Sandra Diaz,1,2 Sophia Zackrisson,1,2 Per Wollmer1,2 1Department of Medical Imaging and Physiology, Skåne University Hospital, Malmö, Sweden; 2Department of Translational Medicine, Lund University, Malmö, Sweden; 3Department of Medical Radiation Physics, Lund University, Malmö, Sweden; 4Department of Design Sciences, Lund University, Lund, Sweden; 5Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Malmö, Sweden *These authors contributed equally to this work Background: Airspace Dimension Assessment with inhaled nanoparticles is a novel method to determine distal airway morphology. This is the first empirical study using Airspace Dimension Assessment with nanoparticles (AiDA) to estimate distal airspace radius. The technology is relatively simple and potentially accessible in clinical outpatient settings. Method: Nineteen never-smoking volunteers performed nanoparticle inhalation tests at multiple breath-hold times, and the difference in nanoparticle concentration of inhaled and exhaled gas was measured. An exponential decay curve was fitted to the concentration of recovered nanoparticles, and airspace dimensions were assessed from the half-life of the decay. Pulmonary tissue density was measured using magnetic resonance imaging (MRI). Results: The distal airspace radius measured by AiDA correlated with lung tissue density as measured by MRI (ρ = -0.584; p = 0.0086). The linear intercept of the logarithm of the exponential decay curve correlated with forced expiratory volume in one second (FEV1) (ρ = 0.549; p = 0.0149). Conclusion: The AiDA method shows potential to be developed into a tool to assess conditions involving changes in distal airways, eg, emphysema. The intercept may reflect airway properties; this finding should be further investigated. Keywords: nanoparticles, respiratory diagnostics, distal airspaces, airspace dimension assessment with nanoparticles, magnetic resonance densitometryAaltonen HLKindvall SSJakobsson JKLöndahl JOlsson LEDiaz SZackrisson SWollmer PDove Medical Pressarticlenanoparticlesrespiratory diagnosticsdistal airspacesAiDAairspace dimension assessmentMR densitometryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2989-2995 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticles respiratory diagnostics distal airspaces AiDA airspace dimension assessment MR densitometry Medicine (General) R5-920
spellingShingle	nanoparticles respiratory diagnostics distal airspaces AiDA airspace dimension assessment MR densitometry Medicine (General) R5-920 Aaltonen HL Kindvall SS Jakobsson JK Löndahl J Olsson LE Diaz S Zackrisson S Wollmer P Airspace Dimension Assessment with nanoparticles reflects lung density as quantified by MRI
description	H Laura Aaltonen,1,2,* Simon S Kindvall,3,* Jonas K Jakobsson,4 Jakob Löndahl,4 Lars E Olsson,3,5 Sandra Diaz,1,2 Sophia Zackrisson,1,2 Per Wollmer1,2 1Department of Medical Imaging and Physiology, Skåne University Hospital, Malmö, Sweden; 2Department of Translational Medicine, Lund University, Malmö, Sweden; 3Department of Medical Radiation Physics, Lund University, Malmö, Sweden; 4Department of Design Sciences, Lund University, Lund, Sweden; 5Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Malmö, Sweden *These authors contributed equally to this work Background: Airspace Dimension Assessment with inhaled nanoparticles is a novel method to determine distal airway morphology. This is the first empirical study using Airspace Dimension Assessment with nanoparticles (AiDA) to estimate distal airspace radius. The technology is relatively simple and potentially accessible in clinical outpatient settings. Method: Nineteen never-smoking volunteers performed nanoparticle inhalation tests at multiple breath-hold times, and the difference in nanoparticle concentration of inhaled and exhaled gas was measured. An exponential decay curve was fitted to the concentration of recovered nanoparticles, and airspace dimensions were assessed from the half-life of the decay. Pulmonary tissue density was measured using magnetic resonance imaging (MRI). Results: The distal airspace radius measured by AiDA correlated with lung tissue density as measured by MRI (ρ = -0.584; p = 0.0086). The linear intercept of the logarithm of the exponential decay curve correlated with forced expiratory volume in one second (FEV1) (ρ = 0.549; p = 0.0149). Conclusion: The AiDA method shows potential to be developed into a tool to assess conditions involving changes in distal airways, eg, emphysema. The intercept may reflect airway properties; this finding should be further investigated. Keywords: nanoparticles, respiratory diagnostics, distal airspaces, airspace dimension assessment with nanoparticles, magnetic resonance densitometry
format	article
author	Aaltonen HL Kindvall SS Jakobsson JK Löndahl J Olsson LE Diaz S Zackrisson S Wollmer P
author_facet	Aaltonen HL Kindvall SS Jakobsson JK Löndahl J Olsson LE Diaz S Zackrisson S Wollmer P
author_sort	Aaltonen HL
title	Airspace Dimension Assessment with nanoparticles reflects lung density as quantified by MRI
title_short	Airspace Dimension Assessment with nanoparticles reflects lung density as quantified by MRI
title_full	Airspace Dimension Assessment with nanoparticles reflects lung density as quantified by MRI
title_fullStr	Airspace Dimension Assessment with nanoparticles reflects lung density as quantified by MRI
title_full_unstemmed	Airspace Dimension Assessment with nanoparticles reflects lung density as quantified by MRI
title_sort	airspace dimension assessment with nanoparticles reflects lung density as quantified by mri
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/79208b4ebe294ce1b74aebe22d78dd73
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Airspace Dimension Assessment with nanoparticles reflects lung density as quantified by MRI

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