Middle-aged individuals may be in a perpetual state of H3N2 influenza virus susceptibility

Influenza exposure in early childhood can affect the immune response to distinct viral strains later in life. Here, Gouma et al. show that contemporary 3c2.A H3N2 virus infections boost non-neutralizing H3N2 antibodies in middle-aged individuals, potentially leaving them vulnerable to recurrent infe...

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Autores principales: Sigrid Gouma, Kangchon Kim, Madison E. Weirick, Megan E. Gumina, Angela Branche, David J. Topham, Emily T. Martin, Arnold S. Monto, Sarah Cobey, Scott E. Hensley
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/792227af26bb4898b50fc41e24abb5db
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Sumario:Influenza exposure in early childhood can affect the immune response to distinct viral strains later in life. Here, Gouma et al. show that contemporary 3c2.A H3N2 virus infections boost non-neutralizing H3N2 antibodies in middle-aged individuals, potentially leaving them vulnerable to recurrent infections.