Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-γ

Abstract Interleukin-28A (IL-28A) modulates CD11c+ dendritic cell (DC) function and promotes type 1T helper (Th1) differentiation, thus suppressing allergic airway diseases. However, the function of the IL-28A isoform IL-28B in these diseases remains largely unknown. In this study, we revealed a nov...

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Autores principales:	Bailing Yan, Feng Chen, Lijun Xu, Yanshi Wang, Xuefu Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7926dae70b104e618ffe6f9fc41769ca
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spelling	oai:doaj.org-article:7926dae70b104e618ffe6f9fc41769ca2021-12-02T16:07:04ZInterleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-γ10.1038/s41598-017-03856-w2045-2322https://doaj.org/article/7926dae70b104e618ffe6f9fc41769ca2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03856-whttps://doaj.org/toc/2045-2322Abstract Interleukin-28A (IL-28A) modulates CD11c+ dendritic cell (DC) function and promotes type 1T helper (Th1) differentiation, thus suppressing allergic airway diseases. However, the function of the IL-28A isoform IL-28B in these diseases remains largely unknown. In this study, we revealed a novel role of IL-28B in inducing type 1 immunity and protecting against ovalbumin (OVA)-induced allergic asthma in mice. IL-28B overexpression in wild-type mice promoted natural killer (NK) cell polarization in the lung, leading to the increased number of interferon (IFN)-γ-producing NK1 cells as well as Th1 differentiation. Importantly, IL-28B overexpression had no protective effect on OVA-induced asthma in IFN-γ-knockout (IFN-γ−/−) mice. These results demonstrate that IL-28B ameliorates experimental allergic asthma via enhancing NK cell polarization, which might be useful for prevention and treatment of allergic asthma.Bailing YanFeng ChenLijun XuYanshi WangXuefu WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bailing Yan Feng Chen Lijun Xu Yanshi Wang Xuefu Wang Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-γ
description	Abstract Interleukin-28A (IL-28A) modulates CD11c+ dendritic cell (DC) function and promotes type 1T helper (Th1) differentiation, thus suppressing allergic airway diseases. However, the function of the IL-28A isoform IL-28B in these diseases remains largely unknown. In this study, we revealed a novel role of IL-28B in inducing type 1 immunity and protecting against ovalbumin (OVA)-induced allergic asthma in mice. IL-28B overexpression in wild-type mice promoted natural killer (NK) cell polarization in the lung, leading to the increased number of interferon (IFN)-γ-producing NK1 cells as well as Th1 differentiation. Importantly, IL-28B overexpression had no protective effect on OVA-induced asthma in IFN-γ-knockout (IFN-γ−/−) mice. These results demonstrate that IL-28B ameliorates experimental allergic asthma via enhancing NK cell polarization, which might be useful for prevention and treatment of allergic asthma.
format	article
author	Bailing Yan Feng Chen Lijun Xu Yanshi Wang Xuefu Wang
author_facet	Bailing Yan Feng Chen Lijun Xu Yanshi Wang Xuefu Wang
author_sort	Bailing Yan
title	Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-γ
title_short	Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-γ
title_full	Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-γ
title_fullStr	Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-γ
title_full_unstemmed	Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-γ
title_sort	interleukin-28b dampens airway inflammation through up-regulation of natural killer cell-derived ifn-γ
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7926dae70b104e618ffe6f9fc41769ca
work_keys_str_mv	AT bailingyan interleukin28bdampensairwayinflammationthroughupregulationofnaturalkillercellderivedifng AT fengchen interleukin28bdampensairwayinflammationthroughupregulationofnaturalkillercellderivedifng AT lijunxu interleukin28bdampensairwayinflammationthroughupregulationofnaturalkillercellderivedifng AT yanshiwang interleukin28bdampensairwayinflammationthroughupregulationofnaturalkillercellderivedifng AT xuefuwang interleukin28bdampensairwayinflammationthroughupregulationofnaturalkillercellderivedifng
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Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-γ

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