Changes in the Sensitization Pattern to <i>Alternaria alternata</i> Allergens in Patients Treated with Alt a 1 Immunotherapy
<i>Alternaria alternata</i> is the most important allergenic fungus, with up to 20% of allergic patients affected. The sensitization profile of patients sensitized to <i>A. alternata</i> and how it changes when treated with immunotherapy is not known. Our objective is to dete...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/79272daf7aaa4128ada1a81cc7840208 |
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| Sumario: | <i>Alternaria alternata</i> is the most important allergenic fungus, with up to 20% of allergic patients affected. The sensitization profile of patients sensitized to <i>A. alternata</i> and how it changes when treated with immunotherapy is not known. Our objective is to determine the allergen recognition pattern of allergic patients to <i>A. alternata</i> and to study its association to the parameters studied in a clinical trial recently published. Sera of 64 patients from the clinical trial of immunotherapy with native major allergen Alt a 1 were analyzed by immunoblotting; 98. 4% of the patients recognized Alt a 1. The percentage of recognition for Alt a 3, Alt a 4, and/or Alt a 6, Alt a 7, Alt a 8, Alt a 10 and/or Alt a 15 was 1.6%, 21.9%, 12.5%, 12.5%, and 12.5% respectively. Of the 64 patients, 45 (70.3%) only recognized Alt a 1 among the allergens present in the <i>A. alternata</i> extract. Immunotherapy with Alt a 1 desensitizes treated patients, reducing their symptoms and medication consumption through the elimination of Alt a 1 sensitization, which is no longer present in the immunoblotting of some patients. There may be gender differences in the pattern of sensitization to <i>A. alternata</i> allergens, among others. |
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