Changes in the Sensitization Pattern to Alternaria alternata Allergens in Patients Treated with Alt a 1 Immunotherapy

Alternaria alternata is the most important allergenic fungus, with up to 20% of allergic patients affected. The sensitization profile of patients sensitized to A. alternata and how it changes when treated with immunotherapy is not known. Our objective is to dete...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	David Rodríguez, Ana I. Tabar, Miriam Castillo, Montserrat Martínez-Gomariz, Isabel C. Dobski, Ricardo Palacios
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alt a 1 immunotherapy <i>Alternaria alternata</i> sensitization pattern immunoblotting allergen Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/79272daf7aaa4128ada1a81cc7840208
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:79272daf7aaa4128ada1a81cc7840208
record_format	dspace
spelling	oai:doaj.org-article:79272daf7aaa4128ada1a81cc78402082021-11-25T18:06:21ZChanges in the Sensitization Pattern to <i>Alternaria alternata</i> Allergens in Patients Treated with Alt a 1 Immunotherapy10.3390/jof71109742309-608Xhttps://doaj.org/article/79272daf7aaa4128ada1a81cc78402082021-11-01T00:00:00Zhttps://www.mdpi.com/2309-608X/7/11/974https://doaj.org/toc/2309-608X<i>Alternaria alternata</i> is the most important allergenic fungus, with up to 20% of allergic patients affected. The sensitization profile of patients sensitized to <i>A. alternata</i> and how it changes when treated with immunotherapy is not known. Our objective is to determine the allergen recognition pattern of allergic patients to <i>A. alternata</i> and to study its association to the parameters studied in a clinical trial recently published. Sera of 64 patients from the clinical trial of immunotherapy with native major allergen Alt a 1 were analyzed by immunoblotting; 98. 4% of the patients recognized Alt a 1. The percentage of recognition for Alt a 3, Alt a 4, and/or Alt a 6, Alt a 7, Alt a 8, Alt a 10 and/or Alt a 15 was 1.6%, 21.9%, 12.5%, 12.5%, and 12.5% respectively. Of the 64 patients, 45 (70.3%) only recognized Alt a 1 among the allergens present in the <i>A. alternata</i> extract. Immunotherapy with Alt a 1 desensitizes treated patients, reducing their symptoms and medication consumption through the elimination of Alt a 1 sensitization, which is no longer present in the immunoblotting of some patients. There may be gender differences in the pattern of sensitization to <i>A. alternata</i> allergens, among others.David RodríguezAna I. TabarMiriam CastilloMontserrat Martínez-GomarizIsabel C. DobskiRicardo PalaciosMDPI AGarticleAlt a 1immunotherapy<i>Alternaria alternata</i>sensitization patternimmunoblottingallergenBiology (General)QH301-705.5ENJournal of Fungi, Vol 7, Iss 974, p 974 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alt a 1 immunotherapy <i>Alternaria alternata</i> sensitization pattern immunoblotting allergen Biology (General) QH301-705.5
spellingShingle	Alt a 1 immunotherapy <i>Alternaria alternata</i> sensitization pattern immunoblotting allergen Biology (General) QH301-705.5 David Rodríguez Ana I. Tabar Miriam Castillo Montserrat Martínez-Gomariz Isabel C. Dobski Ricardo Palacios Changes in the Sensitization Pattern to <i>Alternaria alternata</i> Allergens in Patients Treated with Alt a 1 Immunotherapy
description	<i>Alternaria alternata</i> is the most important allergenic fungus, with up to 20% of allergic patients affected. The sensitization profile of patients sensitized to <i>A. alternata</i> and how it changes when treated with immunotherapy is not known. Our objective is to determine the allergen recognition pattern of allergic patients to <i>A. alternata</i> and to study its association to the parameters studied in a clinical trial recently published. Sera of 64 patients from the clinical trial of immunotherapy with native major allergen Alt a 1 were analyzed by immunoblotting; 98. 4% of the patients recognized Alt a 1. The percentage of recognition for Alt a 3, Alt a 4, and/or Alt a 6, Alt a 7, Alt a 8, Alt a 10 and/or Alt a 15 was 1.6%, 21.9%, 12.5%, 12.5%, and 12.5% respectively. Of the 64 patients, 45 (70.3%) only recognized Alt a 1 among the allergens present in the <i>A. alternata</i> extract. Immunotherapy with Alt a 1 desensitizes treated patients, reducing their symptoms and medication consumption through the elimination of Alt a 1 sensitization, which is no longer present in the immunoblotting of some patients. There may be gender differences in the pattern of sensitization to <i>A. alternata</i> allergens, among others.
format	article
author	David Rodríguez Ana I. Tabar Miriam Castillo Montserrat Martínez-Gomariz Isabel C. Dobski Ricardo Palacios
author_facet	David Rodríguez Ana I. Tabar Miriam Castillo Montserrat Martínez-Gomariz Isabel C. Dobski Ricardo Palacios
author_sort	David Rodríguez
title	Changes in the Sensitization Pattern to <i>Alternaria alternata</i> Allergens in Patients Treated with Alt a 1 Immunotherapy
title_short	Changes in the Sensitization Pattern to <i>Alternaria alternata</i> Allergens in Patients Treated with Alt a 1 Immunotherapy
title_full	Changes in the Sensitization Pattern to <i>Alternaria alternata</i> Allergens in Patients Treated with Alt a 1 Immunotherapy
title_fullStr	Changes in the Sensitization Pattern to <i>Alternaria alternata</i> Allergens in Patients Treated with Alt a 1 Immunotherapy
title_full_unstemmed	Changes in the Sensitization Pattern to <i>Alternaria alternata</i> Allergens in Patients Treated with Alt a 1 Immunotherapy
title_sort	changes in the sensitization pattern to <i>alternaria alternata</i> allergens in patients treated with alt a 1 immunotherapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/79272daf7aaa4128ada1a81cc7840208
work_keys_str_mv	AT davidrodriguez changesinthesensitizationpatterntoialternariaalternataiallergensinpatientstreatedwithalta1immunotherapy AT anaitabar changesinthesensitizationpatterntoialternariaalternataiallergensinpatientstreatedwithalta1immunotherapy AT miriamcastillo changesinthesensitizationpatterntoialternariaalternataiallergensinpatientstreatedwithalta1immunotherapy AT montserratmartinezgomariz changesinthesensitizationpatterntoialternariaalternataiallergensinpatientstreatedwithalta1immunotherapy AT isabelcdobski changesinthesensitizationpatterntoialternariaalternataiallergensinpatientstreatedwithalta1immunotherapy AT ricardopalacios changesinthesensitizationpatterntoialternariaalternataiallergensinpatientstreatedwithalta1immunotherapy
_version_	1718411624480505856

Changes in the Sensitization Pattern to <i>Alternaria alternata</i> Allergens in Patients Treated with Alt a 1 Immunotherapy

Ejemplares similares