Solubility of Luteolin and Other Polyphenolic Compounds in Water, Nonpolar, Polar Aprotic and Protic Solvents by Applying FTIR/HPLC

In recent years, flavonoids have become a highly researched topic due to their health beneficial effects. Since flavonoids’ solubility plays a significant role in their use in pharmaceutical, food, biological, and chemical areas, the determination of suitable solvents is crucial. Fourier transform i...

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Autores principales:	Saša Rajhard, Lucija Hladnik, Filipa A. Vicente, Stanko Srčič, Miha Grilc, Blaž Likozar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	luteolin dissolution fourier transform infrared-attenuated total reflectance (FTIR-ATR) spectroscopy fast quantification tool high-performance liquid chromatography (HPLC) Chemical technology TP1-1185 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/79273ce0f75a4196bd99e70c613ee5e2
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spelling	oai:doaj.org-article:79273ce0f75a4196bd99e70c613ee5e22021-11-25T18:50:42ZSolubility of Luteolin and Other Polyphenolic Compounds in Water, Nonpolar, Polar Aprotic and Protic Solvents by Applying FTIR/HPLC10.3390/pr91119522227-9717https://doaj.org/article/79273ce0f75a4196bd99e70c613ee5e22021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9717/9/11/1952https://doaj.org/toc/2227-9717In recent years, flavonoids have become a highly researched topic due to their health beneficial effects. Since flavonoids’ solubility plays a significant role in their use in pharmaceutical, food, biological, and chemical areas, the determination of suitable solvents is crucial. Fourier transform infrared (FTIR) analysis was used to characterize functional groups of several flavonoids and phenolic compounds, namely luteolin, hesperidin, quercetin, naringenin, gallic acid and tannic acid. Concentration dependence on transmittance was evaluated for these compounds in ethanol. Afterwards, luteolin was chosen as a model flavonoid, with its concentration correlated with transmittance using 15 solvents with different polarities. Luteolin solubility was further corroborated with high-performance liquid chromatography (HPLC). These results shed light on using FTIR as a semi-quantitative method for the initial screening of solvents and the solubility of different compounds while saving time and solvents. Hence, HPLC would only be needed as a final step for the most promising solvents.Saša RajhardLucija HladnikFilipa A. VicenteStanko SrčičMiha GrilcBlaž LikozarMDPI AGarticleluteolindissolutionfourier transform infrared-attenuated total reflectance (FTIR-ATR) spectroscopyfast quantification toolhigh-performance liquid chromatography (HPLC)Chemical technologyTP1-1185ChemistryQD1-999ENProcesses, Vol 9, Iss 1952, p 1952 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	luteolin dissolution fourier transform infrared-attenuated total reflectance (FTIR-ATR) spectroscopy fast quantification tool high-performance liquid chromatography (HPLC) Chemical technology TP1-1185 Chemistry QD1-999
spellingShingle	luteolin dissolution fourier transform infrared-attenuated total reflectance (FTIR-ATR) spectroscopy fast quantification tool high-performance liquid chromatography (HPLC) Chemical technology TP1-1185 Chemistry QD1-999 Saša Rajhard Lucija Hladnik Filipa A. Vicente Stanko Srčič Miha Grilc Blaž Likozar Solubility of Luteolin and Other Polyphenolic Compounds in Water, Nonpolar, Polar Aprotic and Protic Solvents by Applying FTIR/HPLC
description	In recent years, flavonoids have become a highly researched topic due to their health beneficial effects. Since flavonoids’ solubility plays a significant role in their use in pharmaceutical, food, biological, and chemical areas, the determination of suitable solvents is crucial. Fourier transform infrared (FTIR) analysis was used to characterize functional groups of several flavonoids and phenolic compounds, namely luteolin, hesperidin, quercetin, naringenin, gallic acid and tannic acid. Concentration dependence on transmittance was evaluated for these compounds in ethanol. Afterwards, luteolin was chosen as a model flavonoid, with its concentration correlated with transmittance using 15 solvents with different polarities. Luteolin solubility was further corroborated with high-performance liquid chromatography (HPLC). These results shed light on using FTIR as a semi-quantitative method for the initial screening of solvents and the solubility of different compounds while saving time and solvents. Hence, HPLC would only be needed as a final step for the most promising solvents.
format	article
author	Saša Rajhard Lucija Hladnik Filipa A. Vicente Stanko Srčič Miha Grilc Blaž Likozar
author_facet	Saša Rajhard Lucija Hladnik Filipa A. Vicente Stanko Srčič Miha Grilc Blaž Likozar
author_sort	Saša Rajhard
title	Solubility of Luteolin and Other Polyphenolic Compounds in Water, Nonpolar, Polar Aprotic and Protic Solvents by Applying FTIR/HPLC
title_short	Solubility of Luteolin and Other Polyphenolic Compounds in Water, Nonpolar, Polar Aprotic and Protic Solvents by Applying FTIR/HPLC
title_full	Solubility of Luteolin and Other Polyphenolic Compounds in Water, Nonpolar, Polar Aprotic and Protic Solvents by Applying FTIR/HPLC
title_fullStr	Solubility of Luteolin and Other Polyphenolic Compounds in Water, Nonpolar, Polar Aprotic and Protic Solvents by Applying FTIR/HPLC
title_full_unstemmed	Solubility of Luteolin and Other Polyphenolic Compounds in Water, Nonpolar, Polar Aprotic and Protic Solvents by Applying FTIR/HPLC
title_sort	solubility of luteolin and other polyphenolic compounds in water, nonpolar, polar aprotic and protic solvents by applying ftir/hplc
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/79273ce0f75a4196bd99e70c613ee5e2
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Solubility of Luteolin and Other Polyphenolic Compounds in Water, Nonpolar, Polar Aprotic and Protic Solvents by Applying FTIR/HPLC

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