Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix

Colorectal cancers (CRCs) often develop into untreatable metastatic disease of the liver. Here the authors report the modification of extracellular matrix proteins by citrullination in CRC metastases to the liver and propose that inhibition of citrullination could serve as therapeutic avenue in the...

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Autores principales: A. E. Yuzhalin, A. N. Gordon-Weeks, M. L. Tognoli, K. Jones, B. Markelc, R. Konietzny, R. Fischer, A. Muth, E. O’Neill, P. R. Thompson, P. J. Venables, B. M. Kessler, S. Y. Lim, R. J. Muschel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/792ceadda95d4235966746de3a3f6359
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spelling oai:doaj.org-article:792ceadda95d4235966746de3a3f63592021-12-02T16:49:51ZColorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix10.1038/s41467-018-07306-72041-1723https://doaj.org/article/792ceadda95d4235966746de3a3f63592018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07306-7https://doaj.org/toc/2041-1723Colorectal cancers (CRCs) often develop into untreatable metastatic disease of the liver. Here the authors report the modification of extracellular matrix proteins by citrullination in CRC metastases to the liver and propose that inhibition of citrullination could serve as therapeutic avenue in the treatment.A. E. YuzhalinA. N. Gordon-WeeksM. L. TognoliK. JonesB. MarkelcR. KonietznyR. FischerA. MuthE. O’NeillP. R. ThompsonP. J. VenablesB. M. KesslerS. Y. LimR. J. MuschelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
A. E. Yuzhalin
A. N. Gordon-Weeks
M. L. Tognoli
K. Jones
B. Markelc
R. Konietzny
R. Fischer
A. Muth
E. O’Neill
P. R. Thompson
P. J. Venables
B. M. Kessler
S. Y. Lim
R. J. Muschel
Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix
description Colorectal cancers (CRCs) often develop into untreatable metastatic disease of the liver. Here the authors report the modification of extracellular matrix proteins by citrullination in CRC metastases to the liver and propose that inhibition of citrullination could serve as therapeutic avenue in the treatment.
format article
author A. E. Yuzhalin
A. N. Gordon-Weeks
M. L. Tognoli
K. Jones
B. Markelc
R. Konietzny
R. Fischer
A. Muth
E. O’Neill
P. R. Thompson
P. J. Venables
B. M. Kessler
S. Y. Lim
R. J. Muschel
author_facet A. E. Yuzhalin
A. N. Gordon-Weeks
M. L. Tognoli
K. Jones
B. Markelc
R. Konietzny
R. Fischer
A. Muth
E. O’Neill
P. R. Thompson
P. J. Venables
B. M. Kessler
S. Y. Lim
R. J. Muschel
author_sort A. E. Yuzhalin
title Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix
title_short Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix
title_full Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix
title_fullStr Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix
title_full_unstemmed Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix
title_sort colorectal cancer liver metastatic growth depends on pad4-driven citrullination of the extracellular matrix
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/792ceadda95d4235966746de3a3f6359
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