Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases

Malgorzata Smola1,2, Thierry Vandamme1, Adam Sokolowski21Université Louis Pasteur, Faculté de Pharmacie, Département de Chimie Bioorganique, Illkirch Graffenstaden, France; 2Wroclaw University of Technology, Faculty of Chemical Engineering, Wroclaw, Polan...

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Autores principales: Malgorzata Smola, Thierry Vandamme, Adam Sokolowski
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Lenguaje:EN
Publicado: Dove Medical Press 2008
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spelling oai:doaj.org-article:792e01a597ca4d1490801efdfcc660292021-12-02T02:44:05ZNanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases1176-91141178-2013https://doaj.org/article/792e01a597ca4d1490801efdfcc660292008-03-01T00:00:00Zhttp://www.dovepress.com/nanocarriers-as-pulmonary-drug-delivery-systems-to-treat-and-to-diagno-a742https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Malgorzata Smola1,2, Thierry Vandamme1, Adam Sokolowski21Université Louis Pasteur, Faculté de Pharmacie, Département de Chimie Bioorganique, Illkirch Graffenstaden, France; 2Wroclaw University of Technology, Faculty of Chemical Engineering, Wroclaw, PolandAbstract: The purpose of this review is to discuss the impact of nanocarriers administered by pulmonary route to treat and to diagnose respiratory and non respiratory diseases. Indeed, during the past 10 years, the removal of chlorofluorocarbon propellants from industrial and household products intended for the pulmonary route has lead to the developments of new alternative products. Amongst these ones, on one hand, a lot of attention has been focused to improve the bioavailability of marketed drugs intended for respiratory diseases and to develop new concepts for pulmonary administration of drugs and, on the other hand, to use the pulmonary route to administer drugs for systemic diseases. This has led to some marketed products through the last decade. Although the introduction of nanotechnology permitted to step over numerous problems and to improve the bioavailability of drugs, there are, however, unresolved delivery problems to be still addressed. These scientific and industrial innovations and challenges are discussed along this review together with an analysis of the current situation concerning the industrial developments.Keywords: nanotechnology, nanocarriers, nanoparticle, liposome, lung, pulmonary drug delivery, drug targeting, respiratory disease, microemulsion, bioavailability, micelle Malgorzata SmolaThierry VandammeAdam SokolowskiDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 1, Pp 1-19 (2008)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Malgorzata Smola
Thierry Vandamme
Adam Sokolowski
Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases
description Malgorzata Smola1,2, Thierry Vandamme1, Adam Sokolowski21Université Louis Pasteur, Faculté de Pharmacie, Département de Chimie Bioorganique, Illkirch Graffenstaden, France; 2Wroclaw University of Technology, Faculty of Chemical Engineering, Wroclaw, PolandAbstract: The purpose of this review is to discuss the impact of nanocarriers administered by pulmonary route to treat and to diagnose respiratory and non respiratory diseases. Indeed, during the past 10 years, the removal of chlorofluorocarbon propellants from industrial and household products intended for the pulmonary route has lead to the developments of new alternative products. Amongst these ones, on one hand, a lot of attention has been focused to improve the bioavailability of marketed drugs intended for respiratory diseases and to develop new concepts for pulmonary administration of drugs and, on the other hand, to use the pulmonary route to administer drugs for systemic diseases. This has led to some marketed products through the last decade. Although the introduction of nanotechnology permitted to step over numerous problems and to improve the bioavailability of drugs, there are, however, unresolved delivery problems to be still addressed. These scientific and industrial innovations and challenges are discussed along this review together with an analysis of the current situation concerning the industrial developments.Keywords: nanotechnology, nanocarriers, nanoparticle, liposome, lung, pulmonary drug delivery, drug targeting, respiratory disease, microemulsion, bioavailability, micelle
format article
author Malgorzata Smola
Thierry Vandamme
Adam Sokolowski
author_facet Malgorzata Smola
Thierry Vandamme
Adam Sokolowski
author_sort Malgorzata Smola
title Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases
title_short Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases
title_full Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases
title_fullStr Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases
title_full_unstemmed Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases
title_sort nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases
publisher Dove Medical Press
publishDate 2008
url https://doaj.org/article/792e01a597ca4d1490801efdfcc66029
work_keys_str_mv AT malgorzatasmola nanocarriersaspulmonarydrugdeliverysystemstotreatandtodiagnoserespiratoryandnonrespiratorydiseases
AT thierryvandamme nanocarriersaspulmonarydrugdeliverysystemstotreatandtodiagnoserespiratoryandnonrespiratorydiseases
AT adamsokolowski nanocarriersaspulmonarydrugdeliverysystemstotreatandtodiagnoserespiratoryandnonrespiratorydiseases
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