The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity

The intestinal barrier plays an extremely important role in maintaining the immune homeostasis of the gut and the entire body. It is made up of an intricate system of cells, mucus and intestinal microbiota. A complex system of proteins allows the selective permeability of elements that are safe and...

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Autores principales:	Paweł Serek, Monika Oleksy-Wawrzyniak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	intestine barrier gut microbiota zonulin probiotics bacteria infection Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/792e0ede8f3e42b5af3dab2dd8835a29
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spelling	oai:doaj.org-article:792e0ede8f3e42b5af3dab2dd8835a292021-11-11T16:49:55ZThe Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity10.3390/ijms2221113591422-00671661-6596https://doaj.org/article/792e0ede8f3e42b5af3dab2dd8835a292021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11359https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The intestinal barrier plays an extremely important role in maintaining the immune homeostasis of the gut and the entire body. It is made up of an intricate system of cells, mucus and intestinal microbiota. A complex system of proteins allows the selective permeability of elements that are safe and necessary for the proper nutrition of the body. Disturbances in the tightness of this barrier result in the penetration of toxins and other harmful antigens into the system. Such events lead to various digestive tract dysfunctions, systemic infections, food intolerances and autoimmune diseases. Pathogenic and probiotic bacteria, and the compounds they secrete, undoubtedly affect the properties of the intestinal barrier. The discovery of zonulin, a protein with tight junction regulatory activity in the epithelia, sheds new light on the understanding of the role of the gut barrier in promoting health, as well as the formation of diseases. Coincidentally, there is an increasing number of reports on treatment methods that target gut microbiota, which suggests that the prevention of gut-barrier defects may be a viable approach for improving the condition of COVID-19 patients. Various bacteria–intestinal barrier interactions are the subject of this review, aiming to show the current state of knowledge on this topic and its potential therapeutic applications.Paweł SerekMonika Oleksy-WawrzyniakMDPI AGarticleintestine barriergut microbiotazonulinprobioticsbacteriainfectionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11359, p 11359 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intestine barrier gut microbiota zonulin probiotics bacteria infection Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	intestine barrier gut microbiota zonulin probiotics bacteria infection Biology (General) QH301-705.5 Chemistry QD1-999 Paweł Serek Monika Oleksy-Wawrzyniak The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity
description	The intestinal barrier plays an extremely important role in maintaining the immune homeostasis of the gut and the entire body. It is made up of an intricate system of cells, mucus and intestinal microbiota. A complex system of proteins allows the selective permeability of elements that are safe and necessary for the proper nutrition of the body. Disturbances in the tightness of this barrier result in the penetration of toxins and other harmful antigens into the system. Such events lead to various digestive tract dysfunctions, systemic infections, food intolerances and autoimmune diseases. Pathogenic and probiotic bacteria, and the compounds they secrete, undoubtedly affect the properties of the intestinal barrier. The discovery of zonulin, a protein with tight junction regulatory activity in the epithelia, sheds new light on the understanding of the role of the gut barrier in promoting health, as well as the formation of diseases. Coincidentally, there is an increasing number of reports on treatment methods that target gut microbiota, which suggests that the prevention of gut-barrier defects may be a viable approach for improving the condition of COVID-19 patients. Various bacteria–intestinal barrier interactions are the subject of this review, aiming to show the current state of knowledge on this topic and its potential therapeutic applications.
format	article
author	Paweł Serek Monika Oleksy-Wawrzyniak
author_facet	Paweł Serek Monika Oleksy-Wawrzyniak
author_sort	Paweł Serek
title	The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity
title_short	The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity
title_full	The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity
title_fullStr	The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity
title_full_unstemmed	The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity
title_sort	effect of bacterial infections, probiotics and zonulin on intestinal barrier integrity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/792e0ede8f3e42b5af3dab2dd8835a29
work_keys_str_mv	AT pawełserek theeffectofbacterialinfectionsprobioticsandzonulinonintestinalbarrierintegrity AT monikaoleksywawrzyniak theeffectofbacterialinfectionsprobioticsandzonulinonintestinalbarrierintegrity AT pawełserek effectofbacterialinfectionsprobioticsandzonulinonintestinalbarrierintegrity AT monikaoleksywawrzyniak effectofbacterialinfectionsprobioticsandzonulinonintestinalbarrierintegrity
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The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity

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