In situ reprogramming of gut bacteria by oral delivery

It is difficult to precisely target bacterial populations in the mammalian gut. Here the authors use encapsulated phages to deliver dCas9 to E. coli in the mouse gut to modulate RFP expression.

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Autores principales:	Bryan B. Hsu, Isaac N. Plant, Lorena Lyon, Frances M. Anastassacos, Jeffrey C. Way, Pamela A. Silver
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/792e81c6c1904cf7ba9b6609a0a6e187
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spelling	oai:doaj.org-article:792e81c6c1904cf7ba9b6609a0a6e1872021-12-02T19:16:33ZIn situ reprogramming of gut bacteria by oral delivery10.1038/s41467-020-18614-22041-1723https://doaj.org/article/792e81c6c1904cf7ba9b6609a0a6e1872020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18614-2https://doaj.org/toc/2041-1723It is difficult to precisely target bacterial populations in the mammalian gut. Here the authors use encapsulated phages to deliver dCas9 to E. coli in the mouse gut to modulate RFP expression.Bryan B. HsuIsaac N. PlantLorena LyonFrances M. AnastassacosJeffrey C. WayPamela A. SilverNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bryan B. Hsu Isaac N. Plant Lorena Lyon Frances M. Anastassacos Jeffrey C. Way Pamela A. Silver In situ reprogramming of gut bacteria by oral delivery
description	It is difficult to precisely target bacterial populations in the mammalian gut. Here the authors use encapsulated phages to deliver dCas9 to E. coli in the mouse gut to modulate RFP expression.
format	article
author	Bryan B. Hsu Isaac N. Plant Lorena Lyon Frances M. Anastassacos Jeffrey C. Way Pamela A. Silver
author_facet	Bryan B. Hsu Isaac N. Plant Lorena Lyon Frances M. Anastassacos Jeffrey C. Way Pamela A. Silver
author_sort	Bryan B. Hsu
title	In situ reprogramming of gut bacteria by oral delivery
title_short	In situ reprogramming of gut bacteria by oral delivery
title_full	In situ reprogramming of gut bacteria by oral delivery
title_fullStr	In situ reprogramming of gut bacteria by oral delivery
title_full_unstemmed	In situ reprogramming of gut bacteria by oral delivery
title_sort	in situ reprogramming of gut bacteria by oral delivery
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/792e81c6c1904cf7ba9b6609a0a6e187
work_keys_str_mv	AT bryanbhsu insitureprogrammingofgutbacteriabyoraldelivery AT isaacnplant insitureprogrammingofgutbacteriabyoraldelivery AT lorenalyon insitureprogrammingofgutbacteriabyoraldelivery AT francesmanastassacos insitureprogrammingofgutbacteriabyoraldelivery AT jeffreycway insitureprogrammingofgutbacteriabyoraldelivery AT pamelaasilver insitureprogrammingofgutbacteriabyoraldelivery
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In situ reprogramming of gut bacteria by oral delivery

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