Clinical presentation, MRI, histopathology and outcome in a cat with immune-mediated masticatory myositis

Case summary A 4-year-old female spayed domestic shorthair cat was presented with facial swelling, ocular discharge and intermittent bilateral exophthalmos. Haematology revealed mild eosinophilia. Serum biochemistry showed a markedly elevated creatine kinase activity. MRI of the head revealed diffus...

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Autores principales:	Marco Armellini, Lluís Sánchez, Andrea Lorek, G Diane Shelton, Luisa De Risio
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/7931cfa496fb42fabc1f1c13b7001291
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spelling	oai:doaj.org-article:7931cfa496fb42fabc1f1c13b70012912021-11-12T10:03:21ZClinical presentation, MRI, histopathology and outcome in a cat with immune-mediated masticatory myositis2055-116910.1177/20551169211050037https://doaj.org/article/7931cfa496fb42fabc1f1c13b70012912021-10-01T00:00:00Zhttps://doi.org/10.1177/20551169211050037https://doaj.org/toc/2055-1169Case summary A 4-year-old female spayed domestic shorthair cat was presented with facial swelling, ocular discharge and intermittent bilateral exophthalmos. Haematology revealed mild eosinophilia. Serum biochemistry showed a markedly elevated creatine kinase activity. MRI of the head revealed diffuse and severe changes of the masticatory muscles, including irregular areas compatible with fluid or necrosis within the abnormal muscle tissue. Cytological analysis of the left temporal muscle revealed eosinophilic and macrophagic inflammation. Bacterial and fungal cultures were negative. Serological titres against Toxoplasma gondii were compatible with previous exposure. A canine ELISA against masticatory muscle type IIM fibre proteins was positive at 1:4000 (reference interval <1:100). Histopathological examination of the left temporalis muscle revealed moderately severe and multifocal myositis. A diagnosis of immune-mediated masticatory myositis was made and immunosuppressive therapy was started. The cat initially responded to tapering doses of prednisolone, but subsequent relapses required therapy modulation. At the time of writing, 27 months after the initial diagnosis, the cat was in remission, but was diagnosed with diabetes mellitus, probably secondary to chronic glucocorticoid use. Relevance and novel information To our knowledge, this is the first case report to describe the MRI appearance of masticatory myositis in a cat and the second to describe the clinical presentation, histopathology, response to treatment and outcome in a cat with this condition.Marco ArmelliniLluís SánchezAndrea LorekG Diane SheltonLuisa De RisioSAGE PublishingarticleVeterinary medicineSF600-1100ENJournal of Feline Medicine and Surgery Open Reports, Vol 7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Veterinary medicine SF600-1100
spellingShingle	Veterinary medicine SF600-1100 Marco Armellini Lluís Sánchez Andrea Lorek G Diane Shelton Luisa De Risio Clinical presentation, MRI, histopathology and outcome in a cat with immune-mediated masticatory myositis
description	Case summary A 4-year-old female spayed domestic shorthair cat was presented with facial swelling, ocular discharge and intermittent bilateral exophthalmos. Haematology revealed mild eosinophilia. Serum biochemistry showed a markedly elevated creatine kinase activity. MRI of the head revealed diffuse and severe changes of the masticatory muscles, including irregular areas compatible with fluid or necrosis within the abnormal muscle tissue. Cytological analysis of the left temporal muscle revealed eosinophilic and macrophagic inflammation. Bacterial and fungal cultures were negative. Serological titres against Toxoplasma gondii were compatible with previous exposure. A canine ELISA against masticatory muscle type IIM fibre proteins was positive at 1:4000 (reference interval <1:100). Histopathological examination of the left temporalis muscle revealed moderately severe and multifocal myositis. A diagnosis of immune-mediated masticatory myositis was made and immunosuppressive therapy was started. The cat initially responded to tapering doses of prednisolone, but subsequent relapses required therapy modulation. At the time of writing, 27 months after the initial diagnosis, the cat was in remission, but was diagnosed with diabetes mellitus, probably secondary to chronic glucocorticoid use. Relevance and novel information To our knowledge, this is the first case report to describe the MRI appearance of masticatory myositis in a cat and the second to describe the clinical presentation, histopathology, response to treatment and outcome in a cat with this condition.
format	article
author	Marco Armellini Lluís Sánchez Andrea Lorek G Diane Shelton Luisa De Risio
author_facet	Marco Armellini Lluís Sánchez Andrea Lorek G Diane Shelton Luisa De Risio
author_sort	Marco Armellini
title	Clinical presentation, MRI, histopathology and outcome in a cat with immune-mediated masticatory myositis
title_short	Clinical presentation, MRI, histopathology and outcome in a cat with immune-mediated masticatory myositis
title_full	Clinical presentation, MRI, histopathology and outcome in a cat with immune-mediated masticatory myositis
title_fullStr	Clinical presentation, MRI, histopathology and outcome in a cat with immune-mediated masticatory myositis
title_full_unstemmed	Clinical presentation, MRI, histopathology and outcome in a cat with immune-mediated masticatory myositis
title_sort	clinical presentation, mri, histopathology and outcome in a cat with immune-mediated masticatory myositis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/7931cfa496fb42fabc1f1c13b7001291
work_keys_str_mv	AT marcoarmellini clinicalpresentationmrihistopathologyandoutcomeinacatwithimmunemediatedmasticatorymyositis AT lluissanchez clinicalpresentationmrihistopathologyandoutcomeinacatwithimmunemediatedmasticatorymyositis AT andrealorek clinicalpresentationmrihistopathologyandoutcomeinacatwithimmunemediatedmasticatorymyositis AT gdianeshelton clinicalpresentationmrihistopathologyandoutcomeinacatwithimmunemediatedmasticatorymyositis AT luisaderisio clinicalpresentationmrihistopathologyandoutcomeinacatwithimmunemediatedmasticatorymyositis
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Clinical presentation, MRI, histopathology and outcome in a cat with immune-mediated masticatory myositis

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