Analysis of factors that determine weight gain during smoking cessation therapy.

Cigarette smokers are generally known to gain weight after quitting smoking, and such weight gain is thought to contribute to the worsening of glucose tolerance. While smoking cessation therapy such as nicotine replacement is useful to minimize post-cessation weight gain, substantial gain occurs eve...

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Autores principales:	Maki Komiyama, Hiromichi Wada, Shuichi Ura, Hajime Yamakage, Noriko Satoh-Asahara, Akira Shimatsu, Hiroshi Koyama, Koichi Kono, Yuko Takahashi, Koji Hasegawa
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7932f3fe5a054142a619ef337f0fd5b9
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spelling	oai:doaj.org-article:7932f3fe5a054142a619ef337f0fd5b92021-11-18T08:58:36ZAnalysis of factors that determine weight gain during smoking cessation therapy.1932-620310.1371/journal.pone.0072010https://doaj.org/article/7932f3fe5a054142a619ef337f0fd5b92013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23991026/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Cigarette smokers are generally known to gain weight after quitting smoking, and such weight gain is thought to contribute to the worsening of glucose tolerance. While smoking cessation therapy such as nicotine replacement is useful to minimize post-cessation weight gain, substantial gain occurs even during the therapy. The purpose of the present study was to identify factors associated with weight gain during smoking cessation therapy. We evaluated 186 patients(132 males and 54 females)who visited our outpatient clinic for smoking cessation, and successfully achieved smoking abstinence. We performed gender-adjusted regression analysis for the rate of BMI increase from the beginning of cessation to 3 months after initiation. Furthermore, we performed multivariate analysis to investigate factors that determine the BMI increase after smoking cessation. The mean BMI significantly (p<0.0001) increased from 23.5 ± 3.6 kg/m(2) at the initial consultation to 23.9 ± 3.8 kg/m(2) at 3 months after the start of therapy. There was no significant difference in the extent of BMI increase between nicotine patch and varenicline therapy groups. Factors significantly correlated with the %BMI increase at 3 months after the start of therapy were triglyceride (p = 0.0006, βa = 0.260), high-density lipoprotein cholesterol (p = 0.0386, βa = -0.168), daily cigarette consumption (p = 0.0385, βa = 0.154), and the Fagerström Test for Nicotine Dependence (FTND) score (p = 0.0060, βa = 0.203). Stepwise multivariate analysis demonstrated that triglyceride and the FTND score were the factors determining the post-cessation BMI increase and that the FTND score was the strongest one. The present study demonstrated that smokers with a high FTND score are more likely to gain weight during smoking cessation therapy. Thus, smokers with a high nicotine dependency may require intervention against weight gain in the cessation clinic.Maki KomiyamaHiromichi WadaShuichi UraHajime YamakageNoriko Satoh-AsaharaAkira ShimatsuHiroshi KoyamaKoichi KonoYuko TakahashiKoji HasegawaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e72010 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maki Komiyama Hiromichi Wada Shuichi Ura Hajime Yamakage Noriko Satoh-Asahara Akira Shimatsu Hiroshi Koyama Koichi Kono Yuko Takahashi Koji Hasegawa Analysis of factors that determine weight gain during smoking cessation therapy.
description	Cigarette smokers are generally known to gain weight after quitting smoking, and such weight gain is thought to contribute to the worsening of glucose tolerance. While smoking cessation therapy such as nicotine replacement is useful to minimize post-cessation weight gain, substantial gain occurs even during the therapy. The purpose of the present study was to identify factors associated with weight gain during smoking cessation therapy. We evaluated 186 patients(132 males and 54 females)who visited our outpatient clinic for smoking cessation, and successfully achieved smoking abstinence. We performed gender-adjusted regression analysis for the rate of BMI increase from the beginning of cessation to 3 months after initiation. Furthermore, we performed multivariate analysis to investigate factors that determine the BMI increase after smoking cessation. The mean BMI significantly (p<0.0001) increased from 23.5 ± 3.6 kg/m(2) at the initial consultation to 23.9 ± 3.8 kg/m(2) at 3 months after the start of therapy. There was no significant difference in the extent of BMI increase between nicotine patch and varenicline therapy groups. Factors significantly correlated with the %BMI increase at 3 months after the start of therapy were triglyceride (p = 0.0006, βa = 0.260), high-density lipoprotein cholesterol (p = 0.0386, βa = -0.168), daily cigarette consumption (p = 0.0385, βa = 0.154), and the Fagerström Test for Nicotine Dependence (FTND) score (p = 0.0060, βa = 0.203). Stepwise multivariate analysis demonstrated that triglyceride and the FTND score were the factors determining the post-cessation BMI increase and that the FTND score was the strongest one. The present study demonstrated that smokers with a high FTND score are more likely to gain weight during smoking cessation therapy. Thus, smokers with a high nicotine dependency may require intervention against weight gain in the cessation clinic.
format	article
author	Maki Komiyama Hiromichi Wada Shuichi Ura Hajime Yamakage Noriko Satoh-Asahara Akira Shimatsu Hiroshi Koyama Koichi Kono Yuko Takahashi Koji Hasegawa
author_facet	Maki Komiyama Hiromichi Wada Shuichi Ura Hajime Yamakage Noriko Satoh-Asahara Akira Shimatsu Hiroshi Koyama Koichi Kono Yuko Takahashi Koji Hasegawa
author_sort	Maki Komiyama
title	Analysis of factors that determine weight gain during smoking cessation therapy.
title_short	Analysis of factors that determine weight gain during smoking cessation therapy.
title_full	Analysis of factors that determine weight gain during smoking cessation therapy.
title_fullStr	Analysis of factors that determine weight gain during smoking cessation therapy.
title_full_unstemmed	Analysis of factors that determine weight gain during smoking cessation therapy.
title_sort	analysis of factors that determine weight gain during smoking cessation therapy.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7932f3fe5a054142a619ef337f0fd5b9
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Analysis of factors that determine weight gain during smoking cessation therapy.

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