Detection of six novel de novo mutations in individuals with low resilience to psychological stress.

Genetic bases of psychological stress resilience have been studied previously, but mechanisms and genetic variants which are involved in stress resilience are still unclear. The present study aimed to evaluate the associations between variants in dopaminergic pathway genes with stress resilience. Su...

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Autores principales:	Esfandiar Azadmarzabadi, Arvin Haghighatfard
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/79336852c3bd4e4bb99ff5473e215e78
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spelling	oai:doaj.org-article:79336852c3bd4e4bb99ff5473e215e782021-12-02T20:04:42ZDetection of six novel de novo mutations in individuals with low resilience to psychological stress.1932-620310.1371/journal.pone.0256285https://doaj.org/article/79336852c3bd4e4bb99ff5473e215e782021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256285https://doaj.org/toc/1932-6203Genetic bases of psychological stress resilience have been studied previously, but mechanisms and genetic variants which are involved in stress resilience are still unclear. The present study aimed to evaluate the associations between variants in dopaminergic pathway genes with stress resilience. Subjects of the present study were divided into four groups. Group A included persons with normal reactions to major life events stressors; group B included persons with an acute stress reaction to major life events stressor; group C included persons with normal reactions to Crises/catastrophes stressors, and group D included persons with an acute stress reaction to Crises/catastrophes stressors. DNA was extracted from the subject's blood, and the entire length of 14 genes DRD1, DRD2, DRD3, DRD4, DRD5, COMT, DBH, TH, MAOA, DDC, DAT, 5-HTT, BDNF, and GDNF were sequenced by automated sequencers ABI 3700. Results showed 24 point mutations in 12 genes, including 16 SNPs and six novel mutations, which were significantly correlated to low-stress resilience. Most of the SNPs were known as risk alleles in psychiatric disorders. Several associations were found between genetic variants and psychological characteristics. Findings suggest dopaminergic as an important pathway in stress and stress resilience also indicated shared genetic bases between low-stress resilience and several psychiatric disorders.Esfandiar AzadmarzabadiArvin HaghighatfardPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256285 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Esfandiar Azadmarzabadi Arvin Haghighatfard Detection of six novel de novo mutations in individuals with low resilience to psychological stress.
description	Genetic bases of psychological stress resilience have been studied previously, but mechanisms and genetic variants which are involved in stress resilience are still unclear. The present study aimed to evaluate the associations between variants in dopaminergic pathway genes with stress resilience. Subjects of the present study were divided into four groups. Group A included persons with normal reactions to major life events stressors; group B included persons with an acute stress reaction to major life events stressor; group C included persons with normal reactions to Crises/catastrophes stressors, and group D included persons with an acute stress reaction to Crises/catastrophes stressors. DNA was extracted from the subject's blood, and the entire length of 14 genes DRD1, DRD2, DRD3, DRD4, DRD5, COMT, DBH, TH, MAOA, DDC, DAT, 5-HTT, BDNF, and GDNF were sequenced by automated sequencers ABI 3700. Results showed 24 point mutations in 12 genes, including 16 SNPs and six novel mutations, which were significantly correlated to low-stress resilience. Most of the SNPs were known as risk alleles in psychiatric disorders. Several associations were found between genetic variants and psychological characteristics. Findings suggest dopaminergic as an important pathway in stress and stress resilience also indicated shared genetic bases between low-stress resilience and several psychiatric disorders.
format	article
author	Esfandiar Azadmarzabadi Arvin Haghighatfard
author_facet	Esfandiar Azadmarzabadi Arvin Haghighatfard
author_sort	Esfandiar Azadmarzabadi
title	Detection of six novel de novo mutations in individuals with low resilience to psychological stress.
title_short	Detection of six novel de novo mutations in individuals with low resilience to psychological stress.
title_full	Detection of six novel de novo mutations in individuals with low resilience to psychological stress.
title_fullStr	Detection of six novel de novo mutations in individuals with low resilience to psychological stress.
title_full_unstemmed	Detection of six novel de novo mutations in individuals with low resilience to psychological stress.
title_sort	detection of six novel de novo mutations in individuals with low resilience to psychological stress.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/79336852c3bd4e4bb99ff5473e215e78
work_keys_str_mv	AT esfandiarazadmarzabadi detectionofsixnoveldenovomutationsinindividualswithlowresiliencetopsychologicalstress AT arvinhaghighatfard detectionofsixnoveldenovomutationsinindividualswithlowresiliencetopsychologicalstress
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Detection of six novel de novo mutations in individuals with low resilience to psychological stress.

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