Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core

The Mediator complex regulates RNA polymerase II transcription in all eukaryotes. The mammalian Mediator cryo-EM structure reveals the architecture of previously unresolved Tail module and suggests its regulatory role in the complex conformation and interactions.

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Autores principales:	Haiyan Zhao, Natalie Young, Jens Kalchschmidt, Jenna Lieberman, Laila El Khattabi, Rafael Casellas, Francisco J. Asturias
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7934c13067644d569a269ff83cc26d9e
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spelling	oai:doaj.org-article:7934c13067644d569a269ff83cc26d9e2021-12-02T13:34:49ZStructure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core10.1038/s41467-021-21601-w2041-1723https://doaj.org/article/7934c13067644d569a269ff83cc26d9e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21601-whttps://doaj.org/toc/2041-1723The Mediator complex regulates RNA polymerase II transcription in all eukaryotes. The mammalian Mediator cryo-EM structure reveals the architecture of previously unresolved Tail module and suggests its regulatory role in the complex conformation and interactions.Haiyan ZhaoNatalie YoungJens KalchschmidtJenna LiebermanLaila El KhattabiRafael CasellasFrancisco J. AsturiasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haiyan Zhao Natalie Young Jens Kalchschmidt Jenna Lieberman Laila El Khattabi Rafael Casellas Francisco J. Asturias Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core
description	The Mediator complex regulates RNA polymerase II transcription in all eukaryotes. The mammalian Mediator cryo-EM structure reveals the architecture of previously unresolved Tail module and suggests its regulatory role in the complex conformation and interactions.
format	article
author	Haiyan Zhao Natalie Young Jens Kalchschmidt Jenna Lieberman Laila El Khattabi Rafael Casellas Francisco J. Asturias
author_facet	Haiyan Zhao Natalie Young Jens Kalchschmidt Jenna Lieberman Laila El Khattabi Rafael Casellas Francisco J. Asturias
author_sort	Haiyan Zhao
title	Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core
title_short	Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core
title_full	Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core
title_fullStr	Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core
title_full_unstemmed	Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core
title_sort	structure of mammalian mediator complex reveals tail module architecture and interaction with a conserved core
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7934c13067644d569a269ff83cc26d9e
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Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core

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