Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation

Identifying causal variants at GWAS loci is important to understand disease mechanisms. Here the authors use massively parallel reporter assays to identify type 2 diabetes-associated variants that alter cis-regulatory activity, narrowing in on the causal variants and genetic mechanisms behind the di...

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Autores principales:	Shubham Khetan, Susan Kales, Romy Kursawe, Alexandria Jillette, Jacob C. Ulirsch, Steven K. Reilly, Duygu Ucar, Ryan Tewhey, Michael L. Stitzel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7935194eff76489e8d239c6329e3802f
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spelling	oai:doaj.org-article:7935194eff76489e8d239c6329e3802f2021-12-02T19:04:01ZFunctional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation10.1038/s41467-021-25514-62041-1723https://doaj.org/article/7935194eff76489e8d239c6329e3802f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25514-6https://doaj.org/toc/2041-1723Identifying causal variants at GWAS loci is important to understand disease mechanisms. Here the authors use massively parallel reporter assays to identify type 2 diabetes-associated variants that alter cis-regulatory activity, narrowing in on the causal variants and genetic mechanisms behind the disease.Shubham KhetanSusan KalesRomy KursaweAlexandria JilletteJacob C. UlirschSteven K. ReillyDuygu UcarRyan TewheyMichael L. StitzelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shubham Khetan Susan Kales Romy Kursawe Alexandria Jillette Jacob C. Ulirsch Steven K. Reilly Duygu Ucar Ryan Tewhey Michael L. Stitzel Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
description	Identifying causal variants at GWAS loci is important to understand disease mechanisms. Here the authors use massively parallel reporter assays to identify type 2 diabetes-associated variants that alter cis-regulatory activity, narrowing in on the causal variants and genetic mechanisms behind the disease.
format	article
author	Shubham Khetan Susan Kales Romy Kursawe Alexandria Jillette Jacob C. Ulirsch Steven K. Reilly Duygu Ucar Ryan Tewhey Michael L. Stitzel
author_facet	Shubham Khetan Susan Kales Romy Kursawe Alexandria Jillette Jacob C. Ulirsch Steven K. Reilly Duygu Ucar Ryan Tewhey Michael L. Stitzel
author_sort	Shubham Khetan
title	Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
title_short	Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
title_full	Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
title_fullStr	Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
title_full_unstemmed	Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
title_sort	functional characterization of t2d-associated snp effects on baseline and er stress-responsive β cell transcriptional activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7935194eff76489e8d239c6329e3802f
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Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation

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