Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation

Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation

Identifying causal variants at GWAS loci is important to understand disease mechanisms. Here the authors use massively parallel reporter assays to identify type 2 diabetes-associated variants that alter cis-regulatory activity, narrowing in on the causal variants and genetic mechanisms behind the di...

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Autores principales: Shubham Khetan, Susan Kales, Romy Kursawe, Alexandria Jillette, Jacob C. Ulirsch, Steven K. Reilly, Duygu Ucar, Ryan Tewhey, Michael L. Stitzel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/7935194eff76489e8d239c6329e3802f
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