Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance

Silver (Ag) has been used as an antimicrobial agent since a long time, but its molecular mechanism of action was not elucidated due to technical challenges. Here, the authors develop a mass spectrometric approach to identify the Ag-proteome in Staphylococcus aureus, and capture a molecular snapshot...

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Autores principales:	Haibo Wang, Minji Wang, Xiaohan Xu, Peng Gao, Zeling Xu, Qi Zhang, Hongyan Li, Aixin Yan, Richard Yi-Tsun Kao, Hongzhe Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/793574555794407d804bad3dd59bbdde
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spelling	oai:doaj.org-article:793574555794407d804bad3dd59bbdde2021-12-02T17:30:38ZMulti-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance10.1038/s41467-021-23659-y2041-1723https://doaj.org/article/793574555794407d804bad3dd59bbdde2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23659-yhttps://doaj.org/toc/2041-1723Silver (Ag) has been used as an antimicrobial agent since a long time, but its molecular mechanism of action was not elucidated due to technical challenges. Here, the authors develop a mass spectrometric approach to identify the Ag-proteome in Staphylococcus aureus, and capture a molecular snapshot of the dynamic bactericidal mode of action of Ag through targeting multiple biological pathways.Haibo WangMinji WangXiaohan XuPeng GaoZeling XuQi ZhangHongyan LiAixin YanRichard Yi-Tsun KaoHongzhe SunNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haibo Wang Minji Wang Xiaohan Xu Peng Gao Zeling Xu Qi Zhang Hongyan Li Aixin Yan Richard Yi-Tsun Kao Hongzhe Sun Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance
description	Silver (Ag) has been used as an antimicrobial agent since a long time, but its molecular mechanism of action was not elucidated due to technical challenges. Here, the authors develop a mass spectrometric approach to identify the Ag-proteome in Staphylococcus aureus, and capture a molecular snapshot of the dynamic bactericidal mode of action of Ag through targeting multiple biological pathways.
format	article
author	Haibo Wang Minji Wang Xiaohan Xu Peng Gao Zeling Xu Qi Zhang Hongyan Li Aixin Yan Richard Yi-Tsun Kao Hongzhe Sun
author_facet	Haibo Wang Minji Wang Xiaohan Xu Peng Gao Zeling Xu Qi Zhang Hongyan Li Aixin Yan Richard Yi-Tsun Kao Hongzhe Sun
author_sort	Haibo Wang
title	Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance
title_short	Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance
title_full	Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance
title_fullStr	Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance
title_full_unstemmed	Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance
title_sort	multi-target mode of action of silver against staphylococcus aureus endows it with capability to combat antibiotic resistance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/793574555794407d804bad3dd59bbdde
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Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance

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