A Scalable Discrete-Time Integrated CMOS Readout Array for Nanopore Based DNA Sequencing

This paper introduces a high-speed mixed-signal readout array in 130-nm CMOS for the amplification and digitization of picoampere-range signals. Its design is inspired by the needs of emerging DNA sequencing technologies based on biological nanopore sensors. To overcome switching and substrate noise...

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Autores principales:	Yunus Dawji, Mehdi Habibi, Ebrahim Ghafar-Zadeh, Sebastian Magierowski
Formato:	article
Lenguaje:	EN
Publicado:	IEEE 2021
Materias:	DNA nanopore continuous-time ammeter low noise amplifier Electrical engineering. Electronics. Nuclear engineering TK1-9971
Acceso en línea:	https://doaj.org/article/7939ed3587c24a7981700d8405d90323
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spelling	oai:doaj.org-article:7939ed3587c24a7981700d8405d903232021-11-26T00:00:40ZA Scalable Discrete-Time Integrated CMOS Readout Array for Nanopore Based DNA Sequencing2169-353610.1109/ACCESS.2021.3129171https://doaj.org/article/7939ed3587c24a7981700d8405d903232021-01-01T00:00:00Zhttps://ieeexplore.ieee.org/document/9618971/https://doaj.org/toc/2169-3536This paper introduces a high-speed mixed-signal readout array in 130-nm CMOS for the amplification and digitization of picoampere-range signals. Its design is inspired by the needs of emerging DNA sequencing technologies based on biological nanopore sensors. To overcome switching and substrate noise this system adopts an in-pixel analog-to-digital converter (ADC) architecture and a novel readout technique while consuming 10x less power than similar designs described in the literature. The in-pixel ADC architecture is inherently scalable and immune to electrical interference which can be extended to 100s of channels. With a 5 pF input capacitance, the amplifiers achieve a maximum bandwidth of 100 kHz and demonstrate a noise floor as low as 4 fA/<inline-formula> <tex-math notation="LaTeX">$\sqrt {\text{Hz}}$ </tex-math></inline-formula> and a gain in the range of <inline-formula> <tex-math notation="LaTeX">$\text{G}\Omega $ </tex-math></inline-formula> at 10 kHz. Circuit noise behaviour and theoretical maximum performance estimates using behavioural models are also discussed.Yunus DawjiMehdi HabibiEbrahim Ghafar-ZadehSebastian MagierowskiIEEEarticleDNAnanoporecontinuous-timeammeterlow noiseamplifierElectrical engineering. Electronics. Nuclear engineeringTK1-9971ENIEEE Access, Vol 9, Pp 155543-155554 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DNA nanopore continuous-time ammeter low noise amplifier Electrical engineering. Electronics. Nuclear engineering TK1-9971
spellingShingle	DNA nanopore continuous-time ammeter low noise amplifier Electrical engineering. Electronics. Nuclear engineering TK1-9971 Yunus Dawji Mehdi Habibi Ebrahim Ghafar-Zadeh Sebastian Magierowski A Scalable Discrete-Time Integrated CMOS Readout Array for Nanopore Based DNA Sequencing
description	This paper introduces a high-speed mixed-signal readout array in 130-nm CMOS for the amplification and digitization of picoampere-range signals. Its design is inspired by the needs of emerging DNA sequencing technologies based on biological nanopore sensors. To overcome switching and substrate noise this system adopts an in-pixel analog-to-digital converter (ADC) architecture and a novel readout technique while consuming 10x less power than similar designs described in the literature. The in-pixel ADC architecture is inherently scalable and immune to electrical interference which can be extended to 100s of channels. With a 5 pF input capacitance, the amplifiers achieve a maximum bandwidth of 100 kHz and demonstrate a noise floor as low as 4 fA/<inline-formula> <tex-math notation="LaTeX">$\sqrt {\text{Hz}}$ </tex-math></inline-formula> and a gain in the range of <inline-formula> <tex-math notation="LaTeX">$\text{G}\Omega $ </tex-math></inline-formula> at 10 kHz. Circuit noise behaviour and theoretical maximum performance estimates using behavioural models are also discussed.
format	article
author	Yunus Dawji Mehdi Habibi Ebrahim Ghafar-Zadeh Sebastian Magierowski
author_facet	Yunus Dawji Mehdi Habibi Ebrahim Ghafar-Zadeh Sebastian Magierowski
author_sort	Yunus Dawji
title	A Scalable Discrete-Time Integrated CMOS Readout Array for Nanopore Based DNA Sequencing
title_short	A Scalable Discrete-Time Integrated CMOS Readout Array for Nanopore Based DNA Sequencing
title_full	A Scalable Discrete-Time Integrated CMOS Readout Array for Nanopore Based DNA Sequencing
title_fullStr	A Scalable Discrete-Time Integrated CMOS Readout Array for Nanopore Based DNA Sequencing
title_full_unstemmed	A Scalable Discrete-Time Integrated CMOS Readout Array for Nanopore Based DNA Sequencing
title_sort	scalable discrete-time integrated cmos readout array for nanopore based dna sequencing
publisher	IEEE
publishDate	2021
url	https://doaj.org/article/7939ed3587c24a7981700d8405d90323
work_keys_str_mv	AT yunusdawji ascalablediscretetimeintegratedcmosreadoutarrayfornanoporebaseddnasequencing AT mehdihabibi ascalablediscretetimeintegratedcmosreadoutarrayfornanoporebaseddnasequencing AT ebrahimghafarzadeh ascalablediscretetimeintegratedcmosreadoutarrayfornanoporebaseddnasequencing AT sebastianmagierowski ascalablediscretetimeintegratedcmosreadoutarrayfornanoporebaseddnasequencing AT yunusdawji scalablediscretetimeintegratedcmosreadoutarrayfornanoporebaseddnasequencing AT mehdihabibi scalablediscretetimeintegratedcmosreadoutarrayfornanoporebaseddnasequencing AT ebrahimghafarzadeh scalablediscretetimeintegratedcmosreadoutarrayfornanoporebaseddnasequencing AT sebastianmagierowski scalablediscretetimeintegratedcmosreadoutarrayfornanoporebaseddnasequencing
_version_	1718409978568507392

A Scalable Discrete-Time Integrated CMOS Readout Array for Nanopore Based DNA Sequencing

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