Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models

BCL9 and Pygo are components of Wnt enhanceosome, which facilitates β-catenin-dependent transcription. Here, the authors show that deletion of Bcl9 and Pygo suppresses tumorigenesis and extends disease free survival in two different colorectal cancer models, suggesting a strategy for drugging β-cate...

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Autores principales:	Juliusz Mieszczanek, Laurens M. van Tienen, Ashraf E. K. Ibrahim, Douglas J. Winton, Mariann Bienz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7940916dc1a949ae9750bfca333019b2
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spelling	oai:doaj.org-article:7940916dc1a949ae9750bfca333019b22021-12-02T14:38:46ZBcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models10.1038/s41467-018-08164-z2041-1723https://doaj.org/article/7940916dc1a949ae9750bfca333019b22019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08164-zhttps://doaj.org/toc/2041-1723BCL9 and Pygo are components of Wnt enhanceosome, which facilitates β-catenin-dependent transcription. Here, the authors show that deletion of Bcl9 and Pygo suppresses tumorigenesis and extends disease free survival in two different colorectal cancer models, suggesting a strategy for drugging β-catenin signalling in this cancer.Juliusz MieszczanekLaurens M. van TienenAshraf E. K. IbrahimDouglas J. WintonMariann BienzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juliusz Mieszczanek Laurens M. van Tienen Ashraf E. K. Ibrahim Douglas J. Winton Mariann Bienz Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models
description	BCL9 and Pygo are components of Wnt enhanceosome, which facilitates β-catenin-dependent transcription. Here, the authors show that deletion of Bcl9 and Pygo suppresses tumorigenesis and extends disease free survival in two different colorectal cancer models, suggesting a strategy for drugging β-catenin signalling in this cancer.
format	article
author	Juliusz Mieszczanek Laurens M. van Tienen Ashraf E. K. Ibrahim Douglas J. Winton Mariann Bienz
author_facet	Juliusz Mieszczanek Laurens M. van Tienen Ashraf E. K. Ibrahim Douglas J. Winton Mariann Bienz
author_sort	Juliusz Mieszczanek
title	Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models
title_short	Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models
title_full	Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models
title_fullStr	Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models
title_full_unstemmed	Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models
title_sort	bcl9 and pygo synergise downstream of apc to effect intestinal neoplasia in fap mouse models
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7940916dc1a949ae9750bfca333019b2
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Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models

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