Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders

Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders

Siblings of those with autism spectrum disorder (ASD) have increased likelihood of ASD or related subclinical traits. Here, studying 253 ASD families, D’Abate et al. test the predictive value of genomic copy number variation involving ASD-associated loci, with confirmation in a second cohort.

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Autores principales: L. D’Abate, S. Walker, R. K. C. Yuen, K. Tammimies, J. A. Buchanan, R. W. Davies, B. Thiruvahindrapuram, J. Wei, J. Brian, S. E. Bryson, K. Dobkins, J. Howe, R. Landa, J. Leef, D. Messinger, S. Ozonoff, I. M. Smith, W. L. Stone, Z. E. Warren, G. Young, L. Zwaigenbaum, S. W. Scherer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/7940f1b2c2924eec84eda8740660d6c8
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spelling oai:doaj.org-article:7940f1b2c2924eec84eda8740660d6c82021-12-02T17:01:53ZPredictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders10.1038/s41467-019-13380-22041-1723https://doaj.org/article/7940f1b2c2924eec84eda8740660d6c82019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13380-2https://doaj.org/toc/2041-1723Siblings of those with autism spectrum disorder (ASD) have increased likelihood of ASD or related subclinical traits. Here, studying 253 ASD families, D’Abate et al. test the predictive value of genomic copy number variation involving ASD-associated loci, with confirmation in a second cohort.L. D’AbateS. WalkerR. K. C. YuenK. TammimiesJ. A. BuchananR. W. DaviesB. ThiruvahindrapuramJ. WeiJ. BrianS. E. BrysonK. DobkinsJ. HoweR. LandaJ. LeefD. MessingerS. OzonoffI. M. SmithW. L. StoneZ. E. WarrenG. YoungL. ZwaigenbaumS. W. SchererNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
L. D’Abate
S. Walker
R. K. C. Yuen
K. Tammimies
J. A. Buchanan
R. W. Davies
B. Thiruvahindrapuram
J. Wei
J. Brian
S. E. Bryson
K. Dobkins
J. Howe
R. Landa
J. Leef
D. Messinger
S. Ozonoff
I. M. Smith
W. L. Stone
Z. E. Warren
G. Young
L. Zwaigenbaum
S. W. Scherer
Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders
description Siblings of those with autism spectrum disorder (ASD) have increased likelihood of ASD or related subclinical traits. Here, studying 253 ASD families, D’Abate et al. test the predictive value of genomic copy number variation involving ASD-associated loci, with confirmation in a second cohort.
format article
author L. D’Abate
S. Walker
R. K. C. Yuen
K. Tammimies
J. A. Buchanan
R. W. Davies
B. Thiruvahindrapuram
J. Wei
J. Brian
S. E. Bryson
K. Dobkins
J. Howe
R. Landa
J. Leef
D. Messinger
S. Ozonoff
I. M. Smith
W. L. Stone
Z. E. Warren
G. Young
L. Zwaigenbaum
S. W. Scherer
author_facet L. D’Abate
S. Walker
R. K. C. Yuen
K. Tammimies
J. A. Buchanan
R. W. Davies
B. Thiruvahindrapuram
J. Wei
J. Brian
S. E. Bryson
K. Dobkins
J. Howe
R. Landa
J. Leef
D. Messinger
S. Ozonoff
I. M. Smith
W. L. Stone
Z. E. Warren
G. Young
L. Zwaigenbaum
S. W. Scherer
author_sort L. D’Abate
title Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders
title_short Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders
title_full Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders
title_fullStr Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders
title_full_unstemmed Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders
title_sort predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/7940f1b2c2924eec84eda8740660d6c8
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