Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles

Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles

Ae Mftah,1 Fatah H Alhassan,2,3 Mothanna Sadiq Al-Qubaisi,4 Mohamed Ezzat El Zowalaty,4 Thomas J Webster,5,6 Mohammed Sh-eldin,7 Abdullah Rasedee,8 Yun Hin Taufiq-Yap,2,3 Shah Samiur Rashid1 1Department of Chemistry, Faculty of Industrial Sciences and Technology, University Malaysia Pahang, Malaysi...

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Autores principales: Mftah A, Alhassan FH, Al-Qubaisi MS, El Zowalaty ME, Webster TJ, Sh-eldin M, Rasedee A, Taufiq-Yap YH, Rashid SS
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/794165ca91d648e6a78f6ba7c49ab9e7
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spelling oai:doaj.org-article:794165ca91d648e6a78f6ba7c49ab9e72021-12-02T02:10:31ZPhysicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles1178-2013https://doaj.org/article/794165ca91d648e6a78f6ba7c49ab9e72015-01-01T00:00:00Zhttp://www.dovepress.com/physicochemical-properties-cytotoxicity-andnbspantimicrobial-activity--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Ae Mftah,1 Fatah H Alhassan,2,3 Mothanna Sadiq Al-Qubaisi,4 Mohamed Ezzat El Zowalaty,4 Thomas J Webster,5,6 Mohammed Sh-eldin,7 Abdullah Rasedee,8 Yun Hin Taufiq-Yap,2,3 Shah Samiur Rashid1 1Department of Chemistry, Faculty of Industrial Sciences and Technology, University Malaysia Pahang, Malaysia; 2Catalysis Science and Technology Research Centre, 3Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia; 4Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia; 5Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 6Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia; 7Solar Energy Research Institute, University Kebangsaan Malaysia, Selangor, 8Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor, Malaysia Abstract: Nanoparticle sulphated zirconia with Brønsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600°C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Teller surface area measurements, scanning electron microscopy with energy dispersive X-ray spectroscopy, and transmission electron microscopy. Moreover, the anticancer and antimicrobial effects were investigated for the first time. This study showed for the first time that the exposure of cancer cells to sulphated zirconia nanoparticles (3.9–1,000 µg/mL for 24 hours) resulted in a dose-dependent inhibition of cell growth, as determined by (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Similar promising results were observed for reducing bacteria functions. In this manner, this study demonstrated that sulphated zirconia nanoparticles with Brønsted acidic sites should be further studied for a wide range of anticancer and antibacterial applications. Keywords: sulphated zirconia, nanoparticles, antimicrobial, anticancerMftah AAlhassan FHAl-Qubaisi MSEl Zowalaty MEWebster TJSh-eldin MRasedee ATaufiq-Yap YHRashid SSDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 765-774 (2015)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Mftah A
Alhassan FH
Al-Qubaisi MS
El Zowalaty ME
Webster TJ
Sh-eldin M
Rasedee A
Taufiq-Yap YH
Rashid SS
Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles
description Ae Mftah,1 Fatah H Alhassan,2,3 Mothanna Sadiq Al-Qubaisi,4 Mohamed Ezzat El Zowalaty,4 Thomas J Webster,5,6 Mohammed Sh-eldin,7 Abdullah Rasedee,8 Yun Hin Taufiq-Yap,2,3 Shah Samiur Rashid1 1Department of Chemistry, Faculty of Industrial Sciences and Technology, University Malaysia Pahang, Malaysia; 2Catalysis Science and Technology Research Centre, 3Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia; 4Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia; 5Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 6Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia; 7Solar Energy Research Institute, University Kebangsaan Malaysia, Selangor, 8Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor, Malaysia Abstract: Nanoparticle sulphated zirconia with Brønsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600°C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Teller surface area measurements, scanning electron microscopy with energy dispersive X-ray spectroscopy, and transmission electron microscopy. Moreover, the anticancer and antimicrobial effects were investigated for the first time. This study showed for the first time that the exposure of cancer cells to sulphated zirconia nanoparticles (3.9–1,000 µg/mL for 24 hours) resulted in a dose-dependent inhibition of cell growth, as determined by (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Similar promising results were observed for reducing bacteria functions. In this manner, this study demonstrated that sulphated zirconia nanoparticles with Brønsted acidic sites should be further studied for a wide range of anticancer and antibacterial applications. Keywords: sulphated zirconia, nanoparticles, antimicrobial, anticancer
format article
author Mftah A
Alhassan FH
Al-Qubaisi MS
El Zowalaty ME
Webster TJ
Sh-eldin M
Rasedee A
Taufiq-Yap YH
Rashid SS
author_facet Mftah A
Alhassan FH
Al-Qubaisi MS
El Zowalaty ME
Webster TJ
Sh-eldin M
Rasedee A
Taufiq-Yap YH
Rashid SS
author_sort Mftah A
title Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles
title_short Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles
title_full Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles
title_fullStr Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles
title_full_unstemmed Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles
title_sort physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/794165ca91d648e6a78f6ba7c49ab9e7
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