Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment

Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment

Human Treg cells are central to immune tolerance, yet their heterogeneity and differentiation remain incompletely understood. Here the authors perform single-cell RNA and T cell receptor sequencing to resolve Treg cells from healthy individuals and patients with or without acute graft-versus-host di...

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Autores principales: Yuechen Luo, Changlu Xu, Bing Wang, Qing Niu, Xiuhua Su, Yingnan Bai, Shuxian Zhu, Chunxiao Zhao, Yunyan Sun, Jiali Wang, Maolan Liu, Xiaolei Sun, Ge Song, Haidong Cui, Xiaoli Chen, Huifang Huang, Haikun Wang, Mingzhe Han, Erlie Jiang, Lihong Shi, Xiaoming Feng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/7942edb4231e4783bfa50aec2783e956
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spelling oai:doaj.org-article:7942edb4231e4783bfa50aec2783e9562021-12-02T16:06:02ZSingle-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment10.1038/s41467-021-24213-62041-1723https://doaj.org/article/7942edb4231e4783bfa50aec2783e9562021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24213-6https://doaj.org/toc/2041-1723Human Treg cells are central to immune tolerance, yet their heterogeneity and differentiation remain incompletely understood. Here the authors perform single-cell RNA and T cell receptor sequencing to resolve Treg cells from healthy individuals and patients with or without acute graft-versus-host disease revealing Treg complexity in health and disease.Yuechen LuoChanglu XuBing WangQing NiuXiuhua SuYingnan BaiShuxian ZhuChunxiao ZhaoYunyan SunJiali WangMaolan LiuXiaolei SunGe SongHaidong CuiXiaoli ChenHuifang HuangHaikun WangMingzhe HanErlie JiangLihong ShiXiaoming FengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yuechen Luo
Changlu Xu
Bing Wang
Qing Niu
Xiuhua Su
Yingnan Bai
Shuxian Zhu
Chunxiao Zhao
Yunyan Sun
Jiali Wang
Maolan Liu
Xiaolei Sun
Ge Song
Haidong Cui
Xiaoli Chen
Huifang Huang
Haikun Wang
Mingzhe Han
Erlie Jiang
Lihong Shi
Xiaoming Feng
Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment
description Human Treg cells are central to immune tolerance, yet their heterogeneity and differentiation remain incompletely understood. Here the authors perform single-cell RNA and T cell receptor sequencing to resolve Treg cells from healthy individuals and patients with or without acute graft-versus-host disease revealing Treg complexity in health and disease.
format article
author Yuechen Luo
Changlu Xu
Bing Wang
Qing Niu
Xiuhua Su
Yingnan Bai
Shuxian Zhu
Chunxiao Zhao
Yunyan Sun
Jiali Wang
Maolan Liu
Xiaolei Sun
Ge Song
Haidong Cui
Xiaoli Chen
Huifang Huang
Haikun Wang
Mingzhe Han
Erlie Jiang
Lihong Shi
Xiaoming Feng
author_facet Yuechen Luo
Changlu Xu
Bing Wang
Qing Niu
Xiuhua Su
Yingnan Bai
Shuxian Zhu
Chunxiao Zhao
Yunyan Sun
Jiali Wang
Maolan Liu
Xiaolei Sun
Ge Song
Haidong Cui
Xiaoli Chen
Huifang Huang
Haikun Wang
Mingzhe Han
Erlie Jiang
Lihong Shi
Xiaoming Feng
author_sort Yuechen Luo
title Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment
title_short Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment
title_full Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment
title_fullStr Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment
title_full_unstemmed Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment
title_sort single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human treg compartment
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7942edb4231e4783bfa50aec2783e956
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