Use of ibuprofen sustained release for treating osteoarthritic pain: findings from 15 general medical practices in Egypt

Nabil Khalifa,1 Timour El-Husseini,1 Ahmed Morrah,2 Elshenawy Mostafa,3 Hesham Hamoud41Department of Orthopedic Surgery, Ain Shams University, Cairo, Egypt; 2Department of Orthopedic Surgery, Cairo University, Cairo, Egypt; 3Department of Orthopedic Surgery, Mansoura University, Mansoura, Egypt; 4D...

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Autores principales:	Khalifa N, El-Husseini T, Morrah A, Mostafa E, Hamoud H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/794390a70a7f466f957a3620c5c14746
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spelling	oai:doaj.org-article:794390a70a7f466f957a3620c5c147462021-12-02T02:22:57ZUse of ibuprofen sustained release for treating osteoarthritic pain: findings from 15 general medical practices in Egypt1179-156Xhttps://doaj.org/article/794390a70a7f466f957a3620c5c147462014-05-01T00:00:00Zhttp://www.dovepress.com/use-of-ibuprofen-sustained-release-for-treating-osteoarthritic-pain-fi-a16779https://doaj.org/toc/1179-156X Nabil Khalifa,1 Timour El-Husseini,1 Ahmed Morrah,2 Elshenawy Mostafa,3 Hesham Hamoud41Department of Orthopedic Surgery, Ain Shams University, Cairo, Egypt; 2Department of Orthopedic Surgery, Cairo University, Cairo, Egypt; 3Department of Orthopedic Surgery, Mansoura University, Mansoura, Egypt; 4Department of Rheumatology, Azhar University, Cairo, EgyptPurpose: Ibuprofen sustained release (SR) has been shown to provide effective symptomatic pain relief in chronic arthritic conditions such as osteoarthritis in European and US patient populations. Few studies have been conducted in other patient populations. A 4-week prospective multicenter open-label observational study was designed to explore and describe the combined effect of ibuprofen SR and standard medical care in patients suffering from osteoarthritis in 15 general medical practices in Egypt.Patients and methods: In total, 519 patients were prescribed ibuprofen SR 2 ×800 mg once daily for 4 weeks.Results: Ibuprofen SR combined with standard medical care significantly improved day and night pain, with 99.4% of the patients reporting improvement. The treatment reduced the symptom severity of joint tenderness/stiffness and the duration of morning stiffness, and allowed more patients to carry out normal activities. Overall compliance with the prescribed ibuprofen SR regimen was 98.6%. Ibuprofen SR was generally well tolerated with no serious adverse events reported during the study. There was no increase in blood pressure or heart rate.Conclusion: The combined treatment provided effective relief of pain in patients with osteoarthritis in a large real-life general medical practice setting in Egypt. Owing to its convenient once-daily dosing regimen, ibuprofen SR may enhance patient compliance.Keywords: chronic arthritis, compliance, pain score, real-lifeKhalifa NEl-Husseini TMorrah AMostafa EHamoud HDove Medical PressarticleDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol 2014, Iss default, Pp 49-56 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the musculoskeletal system RC925-935
spellingShingle	Diseases of the musculoskeletal system RC925-935 Khalifa N El-Husseini T Morrah A Mostafa E Hamoud H Use of ibuprofen sustained release for treating osteoarthritic pain: findings from 15 general medical practices in Egypt
description	Nabil Khalifa,1 Timour El-Husseini,1 Ahmed Morrah,2 Elshenawy Mostafa,3 Hesham Hamoud41Department of Orthopedic Surgery, Ain Shams University, Cairo, Egypt; 2Department of Orthopedic Surgery, Cairo University, Cairo, Egypt; 3Department of Orthopedic Surgery, Mansoura University, Mansoura, Egypt; 4Department of Rheumatology, Azhar University, Cairo, EgyptPurpose: Ibuprofen sustained release (SR) has been shown to provide effective symptomatic pain relief in chronic arthritic conditions such as osteoarthritis in European and US patient populations. Few studies have been conducted in other patient populations. A 4-week prospective multicenter open-label observational study was designed to explore and describe the combined effect of ibuprofen SR and standard medical care in patients suffering from osteoarthritis in 15 general medical practices in Egypt.Patients and methods: In total, 519 patients were prescribed ibuprofen SR 2 ×800 mg once daily for 4 weeks.Results: Ibuprofen SR combined with standard medical care significantly improved day and night pain, with 99.4% of the patients reporting improvement. The treatment reduced the symptom severity of joint tenderness/stiffness and the duration of morning stiffness, and allowed more patients to carry out normal activities. Overall compliance with the prescribed ibuprofen SR regimen was 98.6%. Ibuprofen SR was generally well tolerated with no serious adverse events reported during the study. There was no increase in blood pressure or heart rate.Conclusion: The combined treatment provided effective relief of pain in patients with osteoarthritis in a large real-life general medical practice setting in Egypt. Owing to its convenient once-daily dosing regimen, ibuprofen SR may enhance patient compliance.Keywords: chronic arthritis, compliance, pain score, real-life
format	article
author	Khalifa N El-Husseini T Morrah A Mostafa E Hamoud H
author_facet	Khalifa N El-Husseini T Morrah A Mostafa E Hamoud H
author_sort	Khalifa N
title	Use of ibuprofen sustained release for treating osteoarthritic pain: findings from 15 general medical practices in Egypt
title_short	Use of ibuprofen sustained release for treating osteoarthritic pain: findings from 15 general medical practices in Egypt
title_full	Use of ibuprofen sustained release for treating osteoarthritic pain: findings from 15 general medical practices in Egypt
title_fullStr	Use of ibuprofen sustained release for treating osteoarthritic pain: findings from 15 general medical practices in Egypt
title_full_unstemmed	Use of ibuprofen sustained release for treating osteoarthritic pain: findings from 15 general medical practices in Egypt
title_sort	use of ibuprofen sustained release for treating osteoarthritic pain: findings from 15 general medical practices in egypt
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/794390a70a7f466f957a3620c5c14746
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Use of ibuprofen sustained release for treating osteoarthritic pain: findings from 15 general medical practices in Egypt

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