Effects of Acute Aerobic Exercise on Response Inhibition in Adult Patients with ADHD

Abstract Previous studies suggest beneficial effects of aerobic exercise on executive functions, which are a core deficit in ADHD. The aim of the present fMRI study was to investigate acute effects of aerobic exercise on inhibitory control and related brain activation in adult patients with ADHD. 23...

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Autores principales:	A. Mehren, J. Özyurt, C. M. Thiel, M. Brandes, A. P. Lam, A. Philipsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7954347ba04746afac56e7727789b5af
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spelling	oai:doaj.org-article:7954347ba04746afac56e7727789b5af2021-12-02T13:35:12ZEffects of Acute Aerobic Exercise on Response Inhibition in Adult Patients with ADHD10.1038/s41598-019-56332-y2045-2322https://doaj.org/article/7954347ba04746afac56e7727789b5af2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56332-yhttps://doaj.org/toc/2045-2322Abstract Previous studies suggest beneficial effects of aerobic exercise on executive functions, which are a core deficit in ADHD. The aim of the present fMRI study was to investigate acute effects of aerobic exercise on inhibitory control and related brain activation in adult patients with ADHD. 23 patients and 23 matched healthy controls performed on a Go/No-go task in an MRI scanner, following both, an exercise condition involving 30 min of cycling at moderate intensity, and a control condition. ADHD patients compared to healthy controls showed increased brain activation during successful inhibition in the exercise compared to the control condition in parietal, temporal, and occipital regions. Exercise did not improve behavioral performance in either group, but in ADHD patients, exercise-related increases in brain activation and behavioral task performance (i.e., correct inhibition rate) negatively correlated with correct inhibition rate in the control condition. Thus, patients with worse inhibition performance showed stronger exercise-related enhancements, indicating that the lack of improvements on the behavioral level for the whole patient group could be due to ceiling effects. Our findings might be an important step in understanding the neural basis of exercise effects and could, in the long term, help in developing alternative treatment approaches for ADHD.A. MehrenJ. ÖzyurtC. M. ThielM. BrandesA. P. LamA. PhilipsenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. Mehren J. Özyurt C. M. Thiel M. Brandes A. P. Lam A. Philipsen Effects of Acute Aerobic Exercise on Response Inhibition in Adult Patients with ADHD
description	Abstract Previous studies suggest beneficial effects of aerobic exercise on executive functions, which are a core deficit in ADHD. The aim of the present fMRI study was to investigate acute effects of aerobic exercise on inhibitory control and related brain activation in adult patients with ADHD. 23 patients and 23 matched healthy controls performed on a Go/No-go task in an MRI scanner, following both, an exercise condition involving 30 min of cycling at moderate intensity, and a control condition. ADHD patients compared to healthy controls showed increased brain activation during successful inhibition in the exercise compared to the control condition in parietal, temporal, and occipital regions. Exercise did not improve behavioral performance in either group, but in ADHD patients, exercise-related increases in brain activation and behavioral task performance (i.e., correct inhibition rate) negatively correlated with correct inhibition rate in the control condition. Thus, patients with worse inhibition performance showed stronger exercise-related enhancements, indicating that the lack of improvements on the behavioral level for the whole patient group could be due to ceiling effects. Our findings might be an important step in understanding the neural basis of exercise effects and could, in the long term, help in developing alternative treatment approaches for ADHD.
format	article
author	A. Mehren J. Özyurt C. M. Thiel M. Brandes A. P. Lam A. Philipsen
author_facet	A. Mehren J. Özyurt C. M. Thiel M. Brandes A. P. Lam A. Philipsen
author_sort	A. Mehren
title	Effects of Acute Aerobic Exercise on Response Inhibition in Adult Patients with ADHD
title_short	Effects of Acute Aerobic Exercise on Response Inhibition in Adult Patients with ADHD
title_full	Effects of Acute Aerobic Exercise on Response Inhibition in Adult Patients with ADHD
title_fullStr	Effects of Acute Aerobic Exercise on Response Inhibition in Adult Patients with ADHD
title_full_unstemmed	Effects of Acute Aerobic Exercise on Response Inhibition in Adult Patients with ADHD
title_sort	effects of acute aerobic exercise on response inhibition in adult patients with adhd
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7954347ba04746afac56e7727789b5af
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Effects of Acute Aerobic Exercise on Response Inhibition in Adult Patients with ADHD

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