LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields

LTP and LTD are involved in shaping hippocampal place field representations. Here, the authors show that de novo pathway-specific hippocampal LTD changes dynamics and stability of newly formed place fields, regulating acquisition and maintenance of novel spatial information in adult rats.

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Detalles Bibliográficos
Autores principales: Donovan M. Ashby, Stan B. Floresco, Anthony G. Phillips, Alexander McGirr, Jeremy K. Seamans, Yu Tian Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
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Acceso en línea:https://doaj.org/article/7955892d980e42c28d73f7ce2fa36609
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Descripción
Sumario:LTP and LTD are involved in shaping hippocampal place field representations. Here, the authors show that de novo pathway-specific hippocampal LTD changes dynamics and stability of newly formed place fields, regulating acquisition and maintenance of novel spatial information in adult rats.