The Effect of Midazolam and Its Reversal Flumazenil on Sedative and Cardiopulmonary Variables in Sheep

The aim of this study was to investigate the effects of flumazenil antagonism after midazolam administration on sedative and cardiopulmonary variables in ewes. Six Awassi ewes were studied at least 14 days apart. The ewes were randomly divided into two groups as midazolam/saline (MDS) and midazolam/...

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Autores principales:	Ünal YAVUZ, Kerem YENER, Adem ŞAHAN
Formato:	article
Lenguaje:	EN
Publicado:	University of Kafkas 2021
Materias:	cardiopulmonary flumazenil midazolam sedation sheep Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/7957160b60494a9999ddc517bd7322df
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spelling	oai:doaj.org-article:7957160b60494a9999ddc517bd7322df2021-12-05T22:01:49ZThe Effect of Midazolam and Its Reversal Flumazenil on Sedative and Cardiopulmonary Variables in Sheep10.9775/kvfd.2021.263001300-60451309-2251https://doaj.org/article/7957160b60494a9999ddc517bd7322df2021-11-01T00:00:00Zhttp://vetdergikafkas.org/uploads/pdf/pdf_KVFD_2861.pdfhttps://doaj.org/toc/1300-6045https://doaj.org/toc/1309-2251The aim of this study was to investigate the effects of flumazenil antagonism after midazolam administration on sedative and cardiopulmonary variables in ewes. Six Awassi ewes were studied at least 14 days apart. The ewes were randomly divided into two groups as midazolam/saline (MDS) and midazolam/flumazenil (MDF). Hemodynamic values, blood gas, metabolic and electrolyte variables and reflex values were determined in both groups before midazolam (0.6 mg/kg, IV) administration (baseline) and after the 5th (T5) and 25th min (T25) of administration. At T25, saline was injected into the MDS and flumazenil (0.02 mg/kg, IV) into the MDF. The same measurements were repeated at the 5th min (T30), 35th min (T60), and 65th min (T90) of saline and flumazenil applications. Midazolam produced deep sedation and a significant increase in reflex scores in both groups at the indicated times (P<0.05). It caused an increase in heart rate (HR), a decrease in systemic and diastolic arterial pressure (SAP, DAP), hypoventilation, mild respiratory acidosis, and adverse effects on metabolic variables at a transient and clinically acceptable level. It was observed that these effects returned to baseline within 5 min with the use of flumazenil in MDF. Flumazenil (0.02 mg/kg, IV) was sufficient to reverse cardiopulmonary adverse effects within 5 min during deep sedation by high-dose midazolam (0.6 mg/kg, IV) in ewes.Ünal YAVUZKerem YENERAdem ŞAHANUniversity of KafkasarticlecardiopulmonaryflumazenilmidazolamsedationsheepVeterinary medicineSF600-1100ENKafkas Universitesi Veteriner Fakultesi Dergisi, Vol 27, Iss 6, Pp 771-779 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiopulmonary flumazenil midazolam sedation sheep Veterinary medicine SF600-1100
spellingShingle	cardiopulmonary flumazenil midazolam sedation sheep Veterinary medicine SF600-1100 Ünal YAVUZ Kerem YENER Adem ŞAHAN The Effect of Midazolam and Its Reversal Flumazenil on Sedative and Cardiopulmonary Variables in Sheep
description	The aim of this study was to investigate the effects of flumazenil antagonism after midazolam administration on sedative and cardiopulmonary variables in ewes. Six Awassi ewes were studied at least 14 days apart. The ewes were randomly divided into two groups as midazolam/saline (MDS) and midazolam/flumazenil (MDF). Hemodynamic values, blood gas, metabolic and electrolyte variables and reflex values were determined in both groups before midazolam (0.6 mg/kg, IV) administration (baseline) and after the 5th (T5) and 25th min (T25) of administration. At T25, saline was injected into the MDS and flumazenil (0.02 mg/kg, IV) into the MDF. The same measurements were repeated at the 5th min (T30), 35th min (T60), and 65th min (T90) of saline and flumazenil applications. Midazolam produced deep sedation and a significant increase in reflex scores in both groups at the indicated times (P<0.05). It caused an increase in heart rate (HR), a decrease in systemic and diastolic arterial pressure (SAP, DAP), hypoventilation, mild respiratory acidosis, and adverse effects on metabolic variables at a transient and clinically acceptable level. It was observed that these effects returned to baseline within 5 min with the use of flumazenil in MDF. Flumazenil (0.02 mg/kg, IV) was sufficient to reverse cardiopulmonary adverse effects within 5 min during deep sedation by high-dose midazolam (0.6 mg/kg, IV) in ewes.
format	article
author	Ünal YAVUZ Kerem YENER Adem ŞAHAN
author_facet	Ünal YAVUZ Kerem YENER Adem ŞAHAN
author_sort	Ünal YAVUZ
title	The Effect of Midazolam and Its Reversal Flumazenil on Sedative and Cardiopulmonary Variables in Sheep
title_short	The Effect of Midazolam and Its Reversal Flumazenil on Sedative and Cardiopulmonary Variables in Sheep
title_full	The Effect of Midazolam and Its Reversal Flumazenil on Sedative and Cardiopulmonary Variables in Sheep
title_fullStr	The Effect of Midazolam and Its Reversal Flumazenil on Sedative and Cardiopulmonary Variables in Sheep
title_full_unstemmed	The Effect of Midazolam and Its Reversal Flumazenil on Sedative and Cardiopulmonary Variables in Sheep
title_sort	effect of midazolam and its reversal flumazenil on sedative and cardiopulmonary variables in sheep
publisher	University of Kafkas
publishDate	2021
url	https://doaj.org/article/7957160b60494a9999ddc517bd7322df
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The Effect of Midazolam and Its Reversal Flumazenil on Sedative and Cardiopulmonary Variables in Sheep

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