Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas

Galectins are carbohydrate binding proteins previously implicated in sensing and repairing damaged lysosomes. Here, the authors show that galectin-9 has specific lysosomal roles in autophagy and contributes to cell degeneration and apoptosis in colitis and pancreatitis in mice.

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Autores principales:	Janaki N. Sudhakar, Hsueh-Han Lu, Hung-Yu Chiang, Ching-Shu Suen, Ming-Jing Hwang, Sung-Yu Wu, Chia-Ning Shen, Yao-Ming Chang, Fu-An Li, Fu-Tong Liu, Jr-Wen Shui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/79593cb82cac49f1bc288649e78208de
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spelling	oai:doaj.org-article:79593cb82cac49f1bc288649e78208de2021-12-02T16:35:00ZLumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas10.1038/s41467-020-18102-72041-1723https://doaj.org/article/79593cb82cac49f1bc288649e78208de2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18102-7https://doaj.org/toc/2041-1723Galectins are carbohydrate binding proteins previously implicated in sensing and repairing damaged lysosomes. Here, the authors show that galectin-9 has specific lysosomal roles in autophagy and contributes to cell degeneration and apoptosis in colitis and pancreatitis in mice.Janaki N. SudhakarHsueh-Han LuHung-Yu ChiangChing-Shu SuenMing-Jing HwangSung-Yu WuChia-Ning ShenYao-Ming ChangFu-An LiFu-Tong LiuJr-Wen ShuiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Janaki N. Sudhakar Hsueh-Han Lu Hung-Yu Chiang Ching-Shu Suen Ming-Jing Hwang Sung-Yu Wu Chia-Ning Shen Yao-Ming Chang Fu-An Li Fu-Tong Liu Jr-Wen Shui Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas
description	Galectins are carbohydrate binding proteins previously implicated in sensing and repairing damaged lysosomes. Here, the authors show that galectin-9 has specific lysosomal roles in autophagy and contributes to cell degeneration and apoptosis in colitis and pancreatitis in mice.
format	article
author	Janaki N. Sudhakar Hsueh-Han Lu Hung-Yu Chiang Ching-Shu Suen Ming-Jing Hwang Sung-Yu Wu Chia-Ning Shen Yao-Ming Chang Fu-An Li Fu-Tong Liu Jr-Wen Shui
author_facet	Janaki N. Sudhakar Hsueh-Han Lu Hung-Yu Chiang Ching-Shu Suen Ming-Jing Hwang Sung-Yu Wu Chia-Ning Shen Yao-Ming Chang Fu-An Li Fu-Tong Liu Jr-Wen Shui
author_sort	Janaki N. Sudhakar
title	Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas
title_short	Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas
title_full	Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas
title_fullStr	Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas
title_full_unstemmed	Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas
title_sort	lumenal galectin-9-lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/79593cb82cac49f1bc288649e78208de
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Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas

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