Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loci associated with fasting glucose and insulin.
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Nature Portfolio
2021
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oai:doaj.org-article:7959f93136b14448a7811855feb4fcf62021-12-02T15:16:22ZSex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability10.1038/s41467-020-19366-92041-1723https://doaj.org/article/7959f93136b14448a7811855feb4fcf62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19366-9https://doaj.org/toc/2041-1723Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loci associated with fasting glucose and insulin.Vasiliki LagouReedik MägiJouke- Jan HottengaHarald GrallertJohn R. B. PerryNabila Bouatia-NajiLetizia MarulloDenis RybinRick JansenJosine L. MinAntigone S. DimasAnna UlrichLiudmila ZudinaJesper R. GådinLongda JiangAlessia FaggianAmélie BonnefondJoao FadistaMaria G. StathopoulouAaron IsaacsSara M. WillemsPau NavarroToshiko TanakaAnne U. JacksonMay E. MontasserJeff R. O’ConnellLawrence F. BielakRebecca J. WebsterRicha SaxenaJeanette M. StaffordBeate St PourcainNicholas J. TimpsonPerttu SaloSo-Youn ShinNajaf AminAlbert V. SmithGuo LiNiek VerweijAnuj GoelIan FordPaul C. D. JohnsonToby JohnsonKaren KapurGudmar ThorleifssonRona J. StrawbridgeLaura J. Rasmussen-TorvikTõnu EskoEvelin MihailovTove FallRoss M. FraserAnubha MahajanStavroula KanoniVilmantas GiedraitisMarcus E. KleberGünther SilbernagelJulia MeyerMartina Müller-NurasyidAndrea GannaAntti-Pekka SarinLoic YengoDmitry ShunginJian’an LuanMomoko HorikoshiPing AnSerena SannaYvonne BoettcherN. William RaynerIlja M. NolteTatijana ZemunikErik van IperenPeter KovacsNicholas D. HastieSarah H. WildStela McLachlanSusan CampbellOzren PolasekOlga CarlsonJosephine EganWieland KiessGonneke WillemsenJohanna KuusistoMarkku LaaksoMaria DimitriouAndrew A. HicksRainer RauramaaStefania BandinelliBarbara ThorandYongmei LiuIva MiljkovicLars LindAlex DoneyMarkus PerolaAroon HingoraniMika KivimakiMeena KumariAmanda J. BennettChristopher J. GrovesChristian HerderHeikki A. KoistinenLeena KinnunenUlf de FaireStephan J. L. BakkerMatti UusitupaColin N. A. PalmerJ. Wouter JukemaNaveed SattarAnneli PoutaHarold SniederEric BoerwinkleJames S. PankowPatrik K. MagnussonUlrika KrusChiara ScapoliEco J. C. N. de GeusMatthias BlüherBruce H. R. WolffenbuttelMichael A. ProvinceGoncalo R. AbecasisJames B. MeigsG. Kees HovinghJaana LindströmJames F. WilsonAlan F. WrightGeorge V. DedoussisStefan R. BornsteinPeter E. H. SchwarzAnke TönjesBernhard R. WinkelmannBernhard O. BoehmWinfried MärzAndres MetspaluJackie F. PricePanos DeloukasAntje KörnerTimo A. LakkaSirkka M. Keinanen-KiukaanniemiTimo E. SaaristoRichard N. BergmanJaakko TuomilehtoNicholas J. WarehamClaudia LangenbergSatu MännistöPaul W. FranksCaroline HaywardVeronique VitartJaakko KaprioSophie Visvikis-SiestBeverley BalkauDavid AltshulerIgor RudanMichael StumvollHarry CampbellCornelia M. van DuijnChristian GiegerThomas IlligLuigi FerrucciNancy L. PedersenPeter P. PramstallerMichael BoehnkeTimothy M. FraylingAlan R. ShuldinerPatricia A. PeyserSharon L. R. KardiaLyle J. PalmerBrenda W. PenninxPierre MenetonTamara B. HarrisGerjan NavisPim van der HarstGeorge Davey SmithNita G. ForouhiRuth J. F. LoosVeikko SalomaaNicole SoranzoDorret I. BoomsmaLeif GroopTiinamaija TuomiAlbert HofmanPatricia B. MunroeVilmundur GudnasonDavid S. SiscovickHugh WatkinsCecile LecoeurPeter VollenweiderAnders Franco-CerecedaPer ErikssonMarjo-Riitta JarvelinKari StefanssonAnders HamstenGeorge NicholsonFredrik KarpeEmmanouil T. DermitzakisCecilia M. LindgrenMark I. McCarthyPhilippe FroguelMarika A. KaakinenValeriya LyssenkoRichard M. WatanabeErik IngelssonJose C. FlorezJosée DupuisInês BarrosoAndrew P. MorrisInga ProkopenkoMeta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)Nature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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Science Q Vasiliki Lagou Reedik Mägi Jouke- Jan Hottenga Harald Grallert John R. B. Perry Nabila Bouatia-Naji Letizia Marullo Denis Rybin Rick Jansen Josine L. Min Antigone S. Dimas Anna Ulrich Liudmila Zudina Jesper R. Gådin Longda Jiang Alessia Faggian Amélie Bonnefond Joao Fadista Maria G. Stathopoulou Aaron Isaacs Sara M. Willems Pau Navarro Toshiko Tanaka Anne U. Jackson May E. Montasser Jeff R. O’Connell Lawrence F. Bielak Rebecca J. Webster Richa Saxena Jeanette M. Stafford Beate St Pourcain Nicholas J. Timpson Perttu Salo So-Youn Shin Najaf Amin Albert V. Smith Guo Li Niek Verweij Anuj Goel Ian Ford Paul C. D. Johnson Toby Johnson Karen Kapur Gudmar Thorleifsson Rona J. Strawbridge Laura J. Rasmussen-Torvik Tõnu Esko Evelin Mihailov Tove Fall Ross M. Fraser Anubha Mahajan Stavroula Kanoni Vilmantas Giedraitis Marcus E. Kleber Günther Silbernagel Julia Meyer Martina Müller-Nurasyid Andrea Ganna Antti-Pekka Sarin Loic Yengo Dmitry Shungin Jian’an Luan Momoko Horikoshi Ping An Serena Sanna Yvonne Boettcher N. William Rayner Ilja M. Nolte Tatijana Zemunik Erik van Iperen Peter Kovacs Nicholas D. Hastie Sarah H. Wild Stela McLachlan Susan Campbell Ozren Polasek Olga Carlson Josephine Egan Wieland Kiess Gonneke Willemsen Johanna Kuusisto Markku Laakso Maria Dimitriou Andrew A. Hicks Rainer Rauramaa Stefania Bandinelli Barbara Thorand Yongmei Liu Iva Miljkovic Lars Lind Alex Doney Markus Perola Aroon Hingorani Mika Kivimaki Meena Kumari Amanda J. Bennett Christopher J. Groves Christian Herder Heikki A. Koistinen Leena Kinnunen Ulf de Faire Stephan J. L. Bakker Matti Uusitupa Colin N. A. Palmer J. Wouter Jukema Naveed Sattar Anneli Pouta Harold Snieder Eric Boerwinkle James S. Pankow Patrik K. Magnusson Ulrika Krus Chiara Scapoli Eco J. C. N. de Geus Matthias Blüher Bruce H. R. Wolffenbuttel Michael A. Province Goncalo R. Abecasis James B. Meigs G. Kees Hovingh Jaana Lindström James F. Wilson Alan F. Wright George V. Dedoussis Stefan R. Bornstein Peter E. H. Schwarz Anke Tönjes Bernhard R. Winkelmann Bernhard O. Boehm Winfried März Andres Metspalu Jackie F. Price Panos Deloukas Antje Körner Timo A. Lakka Sirkka M. Keinanen-Kiukaanniemi Timo E. Saaristo Richard N. Bergman Jaakko Tuomilehto Nicholas J. Wareham Claudia Langenberg Satu Männistö Paul W. Franks Caroline Hayward Veronique Vitart Jaakko Kaprio Sophie Visvikis-Siest Beverley Balkau David Altshuler Igor Rudan Michael Stumvoll Harry Campbell Cornelia M. van Duijn Christian Gieger Thomas Illig Luigi Ferrucci Nancy L. Pedersen Peter P. Pramstaller Michael Boehnke Timothy M. Frayling Alan R. Shuldiner Patricia A. Peyser Sharon L. R. Kardia Lyle J. Palmer Brenda W. Penninx Pierre Meneton Tamara B. Harris Gerjan Navis Pim van der Harst George Davey Smith Nita G. Forouhi Ruth J. F. Loos Veikko Salomaa Nicole Soranzo Dorret I. Boomsma Leif Groop Tiinamaija Tuomi Albert Hofman Patricia B. Munroe Vilmundur Gudnason David S. Siscovick Hugh Watkins Cecile Lecoeur Peter Vollenweider Anders Franco-Cereceda Per Eriksson Marjo-Riitta Jarvelin Kari Stefansson Anders Hamsten George Nicholson Fredrik Karpe Emmanouil T. Dermitzakis Cecilia M. Lindgren Mark I. McCarthy Philippe Froguel Marika A. Kaakinen Valeriya Lyssenko Richard M. Watanabe Erik Ingelsson Jose C. Florez Josée Dupuis Inês Barroso Andrew P. Morris Inga Prokopenko Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability |
description |
Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loci associated with fasting glucose and insulin. |
format |
article |
author |
Vasiliki Lagou Reedik Mägi Jouke- Jan Hottenga Harald Grallert John R. B. Perry Nabila Bouatia-Naji Letizia Marullo Denis Rybin Rick Jansen Josine L. Min Antigone S. Dimas Anna Ulrich Liudmila Zudina Jesper R. Gådin Longda Jiang Alessia Faggian Amélie Bonnefond Joao Fadista Maria G. Stathopoulou Aaron Isaacs Sara M. Willems Pau Navarro Toshiko Tanaka Anne U. Jackson May E. Montasser Jeff R. O’Connell Lawrence F. Bielak Rebecca J. Webster Richa Saxena Jeanette M. Stafford Beate St Pourcain Nicholas J. Timpson Perttu Salo So-Youn Shin Najaf Amin Albert V. Smith Guo Li Niek Verweij Anuj Goel Ian Ford Paul C. D. Johnson Toby Johnson Karen Kapur Gudmar Thorleifsson Rona J. Strawbridge Laura J. Rasmussen-Torvik Tõnu Esko Evelin Mihailov Tove Fall Ross M. Fraser Anubha Mahajan Stavroula Kanoni Vilmantas Giedraitis Marcus E. Kleber Günther Silbernagel Julia Meyer Martina Müller-Nurasyid Andrea Ganna Antti-Pekka Sarin Loic Yengo Dmitry Shungin Jian’an Luan Momoko Horikoshi Ping An Serena Sanna Yvonne Boettcher N. William Rayner Ilja M. Nolte Tatijana Zemunik Erik van Iperen Peter Kovacs Nicholas D. Hastie Sarah H. Wild Stela McLachlan Susan Campbell Ozren Polasek Olga Carlson Josephine Egan Wieland Kiess Gonneke Willemsen Johanna Kuusisto Markku Laakso Maria Dimitriou Andrew A. Hicks Rainer Rauramaa Stefania Bandinelli Barbara Thorand Yongmei Liu Iva Miljkovic Lars Lind Alex Doney Markus Perola Aroon Hingorani Mika Kivimaki Meena Kumari Amanda J. Bennett Christopher J. Groves Christian Herder Heikki A. Koistinen Leena Kinnunen Ulf de Faire Stephan J. L. Bakker Matti Uusitupa Colin N. A. Palmer J. Wouter Jukema Naveed Sattar Anneli Pouta Harold Snieder Eric Boerwinkle James S. Pankow Patrik K. Magnusson Ulrika Krus Chiara Scapoli Eco J. C. N. de Geus Matthias Blüher Bruce H. R. Wolffenbuttel Michael A. Province Goncalo R. Abecasis James B. Meigs G. Kees Hovingh Jaana Lindström James F. Wilson Alan F. Wright George V. Dedoussis Stefan R. Bornstein Peter E. H. Schwarz Anke Tönjes Bernhard R. Winkelmann Bernhard O. Boehm Winfried März Andres Metspalu Jackie F. Price Panos Deloukas Antje Körner Timo A. Lakka Sirkka M. Keinanen-Kiukaanniemi Timo E. Saaristo Richard N. Bergman Jaakko Tuomilehto Nicholas J. Wareham Claudia Langenberg Satu Männistö Paul W. Franks Caroline Hayward Veronique Vitart Jaakko Kaprio Sophie Visvikis-Siest Beverley Balkau David Altshuler Igor Rudan Michael Stumvoll Harry Campbell Cornelia M. van Duijn Christian Gieger Thomas Illig Luigi Ferrucci Nancy L. Pedersen Peter P. Pramstaller Michael Boehnke Timothy M. Frayling Alan R. Shuldiner Patricia A. Peyser Sharon L. R. Kardia Lyle J. Palmer Brenda W. Penninx Pierre Meneton Tamara B. Harris Gerjan Navis Pim van der Harst George Davey Smith Nita G. Forouhi Ruth J. F. Loos Veikko Salomaa Nicole Soranzo Dorret I. Boomsma Leif Groop Tiinamaija Tuomi Albert Hofman Patricia B. Munroe Vilmundur Gudnason David S. Siscovick Hugh Watkins Cecile Lecoeur Peter Vollenweider Anders Franco-Cereceda Per Eriksson Marjo-Riitta Jarvelin Kari Stefansson Anders Hamsten George Nicholson Fredrik Karpe Emmanouil T. Dermitzakis Cecilia M. Lindgren Mark I. McCarthy Philippe Froguel Marika A. Kaakinen Valeriya Lyssenko Richard M. Watanabe Erik Ingelsson Jose C. Florez Josée Dupuis Inês Barroso Andrew P. Morris Inga Prokopenko Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) |
author_facet |
Vasiliki Lagou Reedik Mägi Jouke- Jan Hottenga Harald Grallert John R. B. Perry Nabila Bouatia-Naji Letizia Marullo Denis Rybin Rick Jansen Josine L. Min Antigone S. Dimas Anna Ulrich Liudmila Zudina Jesper R. Gådin Longda Jiang Alessia Faggian Amélie Bonnefond Joao Fadista Maria G. Stathopoulou Aaron Isaacs Sara M. Willems Pau Navarro Toshiko Tanaka Anne U. Jackson May E. Montasser Jeff R. O’Connell Lawrence F. Bielak Rebecca J. Webster Richa Saxena Jeanette M. Stafford Beate St Pourcain Nicholas J. Timpson Perttu Salo So-Youn Shin Najaf Amin Albert V. Smith Guo Li Niek Verweij Anuj Goel Ian Ford Paul C. D. Johnson Toby Johnson Karen Kapur Gudmar Thorleifsson Rona J. Strawbridge Laura J. Rasmussen-Torvik Tõnu Esko Evelin Mihailov Tove Fall Ross M. Fraser Anubha Mahajan Stavroula Kanoni Vilmantas Giedraitis Marcus E. Kleber Günther Silbernagel Julia Meyer Martina Müller-Nurasyid Andrea Ganna Antti-Pekka Sarin Loic Yengo Dmitry Shungin Jian’an Luan Momoko Horikoshi Ping An Serena Sanna Yvonne Boettcher N. William Rayner Ilja M. Nolte Tatijana Zemunik Erik van Iperen Peter Kovacs Nicholas D. Hastie Sarah H. Wild Stela McLachlan Susan Campbell Ozren Polasek Olga Carlson Josephine Egan Wieland Kiess Gonneke Willemsen Johanna Kuusisto Markku Laakso Maria Dimitriou Andrew A. Hicks Rainer Rauramaa Stefania Bandinelli Barbara Thorand Yongmei Liu Iva Miljkovic Lars Lind Alex Doney Markus Perola Aroon Hingorani Mika Kivimaki Meena Kumari Amanda J. Bennett Christopher J. Groves Christian Herder Heikki A. Koistinen Leena Kinnunen Ulf de Faire Stephan J. L. Bakker Matti Uusitupa Colin N. A. Palmer J. Wouter Jukema Naveed Sattar Anneli Pouta Harold Snieder Eric Boerwinkle James S. Pankow Patrik K. Magnusson Ulrika Krus Chiara Scapoli Eco J. C. N. de Geus Matthias Blüher Bruce H. R. Wolffenbuttel Michael A. Province Goncalo R. Abecasis James B. Meigs G. Kees Hovingh Jaana Lindström James F. Wilson Alan F. Wright George V. Dedoussis Stefan R. Bornstein Peter E. H. Schwarz Anke Tönjes Bernhard R. Winkelmann Bernhard O. Boehm Winfried März Andres Metspalu Jackie F. Price Panos Deloukas Antje Körner Timo A. Lakka Sirkka M. Keinanen-Kiukaanniemi Timo E. Saaristo Richard N. Bergman Jaakko Tuomilehto Nicholas J. Wareham Claudia Langenberg Satu Männistö Paul W. Franks Caroline Hayward Veronique Vitart Jaakko Kaprio Sophie Visvikis-Siest Beverley Balkau David Altshuler Igor Rudan Michael Stumvoll Harry Campbell Cornelia M. van Duijn Christian Gieger Thomas Illig Luigi Ferrucci Nancy L. Pedersen Peter P. Pramstaller Michael Boehnke Timothy M. Frayling Alan R. Shuldiner Patricia A. Peyser Sharon L. R. Kardia Lyle J. Palmer Brenda W. Penninx Pierre Meneton Tamara B. Harris Gerjan Navis Pim van der Harst George Davey Smith Nita G. Forouhi Ruth J. F. Loos Veikko Salomaa Nicole Soranzo Dorret I. Boomsma Leif Groop Tiinamaija Tuomi Albert Hofman Patricia B. Munroe Vilmundur Gudnason David S. Siscovick Hugh Watkins Cecile Lecoeur Peter Vollenweider Anders Franco-Cereceda Per Eriksson Marjo-Riitta Jarvelin Kari Stefansson Anders Hamsten George Nicholson Fredrik Karpe Emmanouil T. Dermitzakis Cecilia M. Lindgren Mark I. McCarthy Philippe Froguel Marika A. Kaakinen Valeriya Lyssenko Richard M. Watanabe Erik Ingelsson Jose C. Florez Josée Dupuis Inês Barroso Andrew P. Morris Inga Prokopenko Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) |
author_sort |
Vasiliki Lagou |
title |
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability |
title_short |
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability |
title_full |
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability |
title_fullStr |
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability |
title_full_unstemmed |
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability |
title_sort |
sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/7959f93136b14448a7811855feb4fcf6 |
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