SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike

With the ongoing pandemic, it is critical to understand how natural immunity against SARS-CoV-2 and COVID-19 develops. We have identified that subjects with more severe COVID-19 disease mount a more robust and neutralizing antibody response against SARS-CoV-2 spike protein.

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Autores principales:	Jenna J. Guthmiller, Olivia Stovicek, Jiaolong Wang, Siriruk Changrob, Lei Li, Peter Halfmann, Nai-Ying Zheng, Henry Utset, Christopher T. Stamper, Haley L. Dugan, William D. Miller, Min Huang, Ya-Nan Dai, Christopher A. Nelson, Paige D. Hall, Maud Jansen, Kumaran Shanmugarajah, Jessica S. Donington, Florian Krammer, Daved H. Fremont, Andrzej Joachimiak, Yoshihiro Kawaoka, Vera Tesic, Maria Lucia Madariaga, Patrick C. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/795af7997c9f4b069f3284b32db263f4
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spelling	oai:doaj.org-article:795af7997c9f4b069f3284b32db263f42021-11-03T18:15:38ZSARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike2161-21292150-751110.1128/mBio.02940-20https://doaj.org/article/795af7997c9f4b069f3284b32db263f42021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02940-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 With the ongoing pandemic, it is critical to understand how natural immunity against SARS-CoV-2 and COVID-19 develops. We have identified that subjects with more severe COVID-19 disease mount a more robust and neutralizing antibody response against SARS-CoV-2 spike protein.Jenna J. GuthmillerOlivia StovicekJiaolong WangSiriruk ChangrobLei LiPeter HalfmannNai-Ying ZhengHenry UtsetChristopher T. StamperHaley L. DuganWilliam D. MillerMin HuangYa-Nan DaiChristopher A. NelsonPaige D. HallMaud JansenKumaran ShanmugarajahJessica S. DoningtonFlorian KrammerDaved H. FremontAndrzej JoachimiakYoshihiro KawaokaVera TesicMaria Lucia MadariagaPatrick C. WilsonAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Jenna J. Guthmiller Olivia Stovicek Jiaolong Wang Siriruk Changrob Lei Li Peter Halfmann Nai-Ying Zheng Henry Utset Christopher T. Stamper Haley L. Dugan William D. Miller Min Huang Ya-Nan Dai Christopher A. Nelson Paige D. Hall Maud Jansen Kumaran Shanmugarajah Jessica S. Donington Florian Krammer Daved H. Fremont Andrzej Joachimiak Yoshihiro Kawaoka Vera Tesic Maria Lucia Madariaga Patrick C. Wilson SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike
description	With the ongoing pandemic, it is critical to understand how natural immunity against SARS-CoV-2 and COVID-19 develops. We have identified that subjects with more severe COVID-19 disease mount a more robust and neutralizing antibody response against SARS-CoV-2 spike protein.
format	article
author	Jenna J. Guthmiller Olivia Stovicek Jiaolong Wang Siriruk Changrob Lei Li Peter Halfmann Nai-Ying Zheng Henry Utset Christopher T. Stamper Haley L. Dugan William D. Miller Min Huang Ya-Nan Dai Christopher A. Nelson Paige D. Hall Maud Jansen Kumaran Shanmugarajah Jessica S. Donington Florian Krammer Daved H. Fremont Andrzej Joachimiak Yoshihiro Kawaoka Vera Tesic Maria Lucia Madariaga Patrick C. Wilson
author_facet	Jenna J. Guthmiller Olivia Stovicek Jiaolong Wang Siriruk Changrob Lei Li Peter Halfmann Nai-Ying Zheng Henry Utset Christopher T. Stamper Haley L. Dugan William D. Miller Min Huang Ya-Nan Dai Christopher A. Nelson Paige D. Hall Maud Jansen Kumaran Shanmugarajah Jessica S. Donington Florian Krammer Daved H. Fremont Andrzej Joachimiak Yoshihiro Kawaoka Vera Tesic Maria Lucia Madariaga Patrick C. Wilson
author_sort	Jenna J. Guthmiller
title	SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike
title_short	SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike
title_full	SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike
title_fullStr	SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike
title_full_unstemmed	SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike
title_sort	sars-cov-2 infection severity is linked to superior humoral immunity against the spike
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/795af7997c9f4b069f3284b32db263f4
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SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike

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