Utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer

Abstract An increasing number of studies have indicated that red blood cell distribution width (RDW) may be a novel biomarker for the diagnosis and prognosis of various malignancies. However, to date, data on the association of RDW with non-small cell lung cancer (NSCLC) are unclear. Our present stu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bin Song, Pengchong Shi, Jianhong Xiao, Yanfang Song, Menglu Zeng, Yingping Cao, Xianjin Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/795e0d9c8d394715bd754ab04baea04f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:795e0d9c8d394715bd754ab04baea04f
record_format	dspace
spelling	oai:doaj.org-article:795e0d9c8d394715bd754ab04baea04f2021-12-02T18:48:00ZUtility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer10.1038/s41598-020-72585-42045-2322https://doaj.org/article/795e0d9c8d394715bd754ab04baea04f2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-72585-4https://doaj.org/toc/2045-2322Abstract An increasing number of studies have indicated that red blood cell distribution width (RDW) may be a novel biomarker for the diagnosis and prognosis of various malignancies. However, to date, data on the association of RDW with non-small cell lung cancer (NSCLC) are unclear. Our present study aimed to explore the value of RDW in NSCLC patients. A total of 338 NSCLC patients, 109 small cell lung cancer (SCLC) patients, and 302 healthy participants were retrospectively analyzed between January 2016 and December 2018. In the present study, we found that RDW was significantly increased in NSCLC patients. Receiver-operating characteristic (ROC) analysis showed that the area under the ROC curve (AUC) of RDW was 0.753 in discriminating NSCLC patients from healthy participants, the optimal cut-off value of RDW was 12.95, and the specificity and sensitivity were 76.33% and 76.16%, respectively. Further analysis found that RDW can enhance the diagnostic performance of Cyfra21-1 and NSE in discriminating NSCLC patients from healthy participants or SCLC patients. Among NSCLC patients, RDW was significantly correlated with TNM stage, T stage, N stage, M stage, and Cyfra21-1, indicating that RDW may be helpful for predicting the prognosis of NSCLC patients. Our findings suggest that RDW can be used as an auxiliary marker for the diagnosis and prognosis of NSCLC.Bin SongPengchong ShiJianhong XiaoYanfang SongMenglu ZengYingping CaoXianjin ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bin Song Pengchong Shi Jianhong Xiao Yanfang Song Menglu Zeng Yingping Cao Xianjin Zhu Utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer
description	Abstract An increasing number of studies have indicated that red blood cell distribution width (RDW) may be a novel biomarker for the diagnosis and prognosis of various malignancies. However, to date, data on the association of RDW with non-small cell lung cancer (NSCLC) are unclear. Our present study aimed to explore the value of RDW in NSCLC patients. A total of 338 NSCLC patients, 109 small cell lung cancer (SCLC) patients, and 302 healthy participants were retrospectively analyzed between January 2016 and December 2018. In the present study, we found that RDW was significantly increased in NSCLC patients. Receiver-operating characteristic (ROC) analysis showed that the area under the ROC curve (AUC) of RDW was 0.753 in discriminating NSCLC patients from healthy participants, the optimal cut-off value of RDW was 12.95, and the specificity and sensitivity were 76.33% and 76.16%, respectively. Further analysis found that RDW can enhance the diagnostic performance of Cyfra21-1 and NSE in discriminating NSCLC patients from healthy participants or SCLC patients. Among NSCLC patients, RDW was significantly correlated with TNM stage, T stage, N stage, M stage, and Cyfra21-1, indicating that RDW may be helpful for predicting the prognosis of NSCLC patients. Our findings suggest that RDW can be used as an auxiliary marker for the diagnosis and prognosis of NSCLC.
format	article
author	Bin Song Pengchong Shi Jianhong Xiao Yanfang Song Menglu Zeng Yingping Cao Xianjin Zhu
author_facet	Bin Song Pengchong Shi Jianhong Xiao Yanfang Song Menglu Zeng Yingping Cao Xianjin Zhu
author_sort	Bin Song
title	Utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer
title_short	Utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer
title_full	Utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer
title_fullStr	Utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer
title_full_unstemmed	Utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer
title_sort	utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/795e0d9c8d394715bd754ab04baea04f
work_keys_str_mv	AT binsong utilityofredcelldistributionwidthasadiagnosticandprognosticmarkerinnonsmallcelllungcancer AT pengchongshi utilityofredcelldistributionwidthasadiagnosticandprognosticmarkerinnonsmallcelllungcancer AT jianhongxiao utilityofredcelldistributionwidthasadiagnosticandprognosticmarkerinnonsmallcelllungcancer AT yanfangsong utilityofredcelldistributionwidthasadiagnosticandprognosticmarkerinnonsmallcelllungcancer AT mengluzeng utilityofredcelldistributionwidthasadiagnosticandprognosticmarkerinnonsmallcelllungcancer AT yingpingcao utilityofredcelldistributionwidthasadiagnosticandprognosticmarkerinnonsmallcelllungcancer AT xianjinzhu utilityofredcelldistributionwidthasadiagnosticandprognosticmarkerinnonsmallcelllungcancer
_version_	1718377632014270464

Utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer

Ejemplares similares