Creb5 establishes the competence for Prg4 expression in articular cartilage

Zhang et al. identify Creb5 as a transcription factor that is required for induction of Prg4 expression by TGFβ and EGFR ligands. They show that Creb5 directly binds to two Prg4 promoter-proximal regulatory elements, working together with a more distal regulatory element to drive induction of Prg4 b...

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Autores principales:	Cheng-Hai Zhang, Yao Gao, Unmesh Jadhav, Han-Hwa Hung, Kristina M. Holton, Alan J. Grodzinsky, Ramesh A. Shivdasani, Andrew B. Lassar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7960c992d8174a428cf9f533ac859690
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spelling	oai:doaj.org-article:7960c992d8174a428cf9f533ac8596902021-12-02T11:36:25ZCreb5 establishes the competence for Prg4 expression in articular cartilage10.1038/s42003-021-01857-02399-3642https://doaj.org/article/7960c992d8174a428cf9f533ac8596902021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01857-0https://doaj.org/toc/2399-3642Zhang et al. identify Creb5 as a transcription factor that is required for induction of Prg4 expression by TGFβ and EGFR ligands. They show that Creb5 directly binds to two Prg4 promoter-proximal regulatory elements, working together with a more distal regulatory element to drive induction of Prg4 by TGFβ. These findings provide new insight into the molecular regulation of Prg4 expression in superficial zone articular chondrocytes.Cheng-Hai ZhangYao GaoUnmesh JadhavHan-Hwa HungKristina M. HoltonAlan J. GrodzinskyRamesh A. ShivdasaniAndrew B. LassarNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Cheng-Hai Zhang Yao Gao Unmesh Jadhav Han-Hwa Hung Kristina M. Holton Alan J. Grodzinsky Ramesh A. Shivdasani Andrew B. Lassar Creb5 establishes the competence for Prg4 expression in articular cartilage
description	Zhang et al. identify Creb5 as a transcription factor that is required for induction of Prg4 expression by TGFβ and EGFR ligands. They show that Creb5 directly binds to two Prg4 promoter-proximal regulatory elements, working together with a more distal regulatory element to drive induction of Prg4 by TGFβ. These findings provide new insight into the molecular regulation of Prg4 expression in superficial zone articular chondrocytes.
format	article
author	Cheng-Hai Zhang Yao Gao Unmesh Jadhav Han-Hwa Hung Kristina M. Holton Alan J. Grodzinsky Ramesh A. Shivdasani Andrew B. Lassar
author_facet	Cheng-Hai Zhang Yao Gao Unmesh Jadhav Han-Hwa Hung Kristina M. Holton Alan J. Grodzinsky Ramesh A. Shivdasani Andrew B. Lassar
author_sort	Cheng-Hai Zhang
title	Creb5 establishes the competence for Prg4 expression in articular cartilage
title_short	Creb5 establishes the competence for Prg4 expression in articular cartilage
title_full	Creb5 establishes the competence for Prg4 expression in articular cartilage
title_fullStr	Creb5 establishes the competence for Prg4 expression in articular cartilage
title_full_unstemmed	Creb5 establishes the competence for Prg4 expression in articular cartilage
title_sort	creb5 establishes the competence for prg4 expression in articular cartilage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7960c992d8174a428cf9f533ac859690
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Creb5 establishes the competence for Prg4 expression in articular cartilage

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