Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives

Helena D Zomer,1 Atanásio S Vidane,1 Natalia N Gonçalves,1 Carlos E Ambrósio2 1Department of Surgery, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil; 2Department of Veterinary Medicine, Faculty...

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Autores principales:	Zomer HD, Vidane AS, Gonçalves NN, Ambrósio CE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/796339df79c542b4b5b0c15ce07b7c1d
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spelling	oai:doaj.org-article:796339df79c542b4b5b0c15ce07b7c1d2021-12-02T02:09:08ZMesenchymal and induced pluripotent stem cells: general insights and clinical perspectives1178-6957https://doaj.org/article/796339df79c542b4b5b0c15ce07b7c1d2015-09-01T00:00:00Zhttps://www.dovepress.com/mesenchymal-and-induced-pluripotent-stem-cells-general-insights-and-cl-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Helena D Zomer,1 Atanásio S Vidane,1 Natalia N Gonçalves,1 Carlos E Ambrósio2 1Department of Surgery, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil; 2Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil Abstract: Mesenchymal stem cells have awakened a great deal of interest in regenerative medicine due to their plasticity, and immunomodulatory and anti-inflammatory properties. They are high-yield and can be acquired through noninvasive methods from adult tissues. Moreover, they are nontumorigenic and are the most widely studied. On the other hand, induced pluripotent stem (iPS) cells can be derived directly from adult cells through gene reprogramming. The new iPS technology avoids the embryo destruction or manipulation to generate pluripotent cells, therefore, are exempt from ethical implication surrounding embryonic stem cell use. The pre-differentiation of iPS cells ensures the safety of future approaches. Both mesenchymal stem cells and iPS cells can be used for autologous cell transplantations without the risk of immune rejection and represent a great opportunity for future alternative therapies. In this review we discussed the therapeutic perspectives using mesenchymal and iPS cells. Keywords: cell transplantation, cell therapy, iPS, MSCZomer HDVidane ASGonçalves NNAmbrósio CEDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2015, Iss default, Pp 125-134 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Zomer HD Vidane AS Gonçalves NN Ambrósio CE Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives
description	Helena D Zomer,1 Atanásio S Vidane,1 Natalia N Gonçalves,1 Carlos E Ambrósio2 1Department of Surgery, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil; 2Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil Abstract: Mesenchymal stem cells have awakened a great deal of interest in regenerative medicine due to their plasticity, and immunomodulatory and anti-inflammatory properties. They are high-yield and can be acquired through noninvasive methods from adult tissues. Moreover, they are nontumorigenic and are the most widely studied. On the other hand, induced pluripotent stem (iPS) cells can be derived directly from adult cells through gene reprogramming. The new iPS technology avoids the embryo destruction or manipulation to generate pluripotent cells, therefore, are exempt from ethical implication surrounding embryonic stem cell use. The pre-differentiation of iPS cells ensures the safety of future approaches. Both mesenchymal stem cells and iPS cells can be used for autologous cell transplantations without the risk of immune rejection and represent a great opportunity for future alternative therapies. In this review we discussed the therapeutic perspectives using mesenchymal and iPS cells. Keywords: cell transplantation, cell therapy, iPS, MSC
format	article
author	Zomer HD Vidane AS Gonçalves NN Ambrósio CE
author_facet	Zomer HD Vidane AS Gonçalves NN Ambrósio CE
author_sort	Zomer HD
title	Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives
title_short	Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives
title_full	Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives
title_fullStr	Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives
title_full_unstemmed	Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives
title_sort	mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/796339df79c542b4b5b0c15ce07b7c1d
work_keys_str_mv	AT zomerhd mesenchymalandinducedpluripotentstemcellsgeneralinsightsandclinicalperspectives AT vidaneas mesenchymalandinducedpluripotentstemcellsgeneralinsightsandclinicalperspectives AT goncalvesnn mesenchymalandinducedpluripotentstemcellsgeneralinsightsandclinicalperspectives AT ambrosioce mesenchymalandinducedpluripotentstemcellsgeneralinsightsandclinicalperspectives
_version_	1718402656168312832

Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives

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